Serum Concentration of Ghrelin, Oxidative Stress and Lipid Parameters in Obese Subjects

Year 2018, Volume: 77 Issue: 2, 55 - 58, 02.12.2018

Sevilay Zora Turkan Yigitbasi Gozde Ulfer Nesrin Emekli

Abstract

DOI: 10.26650/EurJBiol.2018.18008

Objective: Ghrelin is a hormone with
peptide structure. It has fatty tissue and increases appetite. Obesity is a
multifactorial chronic disease characterized by an increase in fat tissue. Fat
tissue, like the endocrine organ, triggers oxidative stress and can lead to the
development of obesity-related pathologies. The purpose of this study is to
examine the relationship between the ghrelin in blood, and oxidative stress and
lipid parameters.

Materials and Methods: The study was
conducted with  61 obese and 24 healthy
individuals. Ghreline levels were measured using the ELISA method, while total
antioxidant status (TAS) and oxidant status (TOS), triglyceride (TG), total
cholesterol (TC), HDL-cholesterol (HDL-C) and LDL cholesterol (LDL-C) levels
were measured using the photometric method.

Results: A negative correlation was found
between body mass index (BMI) and ghrelin levels in the obese group
(p<0.05). But there was no significant difference of ghrelin levels in obese
and control groups (p>0.05). TAS was observed to be lower in obese compared
to control group, while The Oxidative Stress Index (OSI) was found to be
significantly higher than the obese group (p<0.05). TG levels were found to
be increased in obese; whereas ghrelin, TC, LDL-C and HDL-C levels did not show
any difference (p>0.05).

Conclusion: Increasing obesity level (BMI)
and decreasing ghrelin level were found to be correlated. New studies are
needed in order to discover the changes in ghrelin level connected to oxidative
stress. 

Keywords

Ghrelin, obesity, oxidative stress

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