Year 2019, Volume 78 , Issue 2, Pages 147 - 155 2019-12-06

Objective: Sepsis leads to conditions such as inflammatory and anti-inflammatory process, circulatory abnormalities, cellular and humoral reactions. Endotoxin-induced oxidative stress causes injury in the liver. The aim of this study was to evaluate the effects of a radical scavenger Tempol in lipopolysaccharide (LPS)-induced liver injury in rats. Materials and Methods: Male Wistar rats were divided into four groups: Control, LPS (15 mg/kg), LPS + Tempol group (100 mg/kg Tempol, three hours after LPS administration) and Tempol (100 mg/kg). Blood glucose and body temperature were measured during the experiment. Superoxide dismutase (SOD), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and C-reactive protein (CRP) levels were measured in plasma or liver tissue. Furthermore, histopathological changes and myeloperoxidase-stained leukocytes infiltration were assessed in liver tissue. Results: LPS caused tissue damage and leukocytes infiltration, increased AST, ALT and CRP levels, and decreased body temperature, blood glucose and SOD levels. Tempol reduced AST and ALT levels and increased SOD levels. Tempol did not prevent tissue damage, leukocytes infiltration and increment of CRP levels. There were no changes in body temperature and blood glucose levels. Conclusion: The present study suggests that tempol may have antioxidant properties in LPS-induced liver injury. These results may contribute to a better understanding of the role of tempol and basic mechanisms of underlying oxidative stressrelated liver injury for further investigations.
Lipopolysaccharide, Liver, Tempol
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Primary Language en
Subjects Science
Journal Section Research Articles

Orcid: 0000-0001-6404-5687
Author: Perihan Sinem SERİN
Institution: Yeditepe University Specialty Hospital
Country: Turkey

Orcid: 0000-0001-8408-2610
Author: Aslı KANDİL (Primary Author)
Country: Turkey

Orcid: 0000-0003-2706-9625
Author: Huri BULUT
Institution: Bezmialem Vakif University
Country: Turkey

Author: Tugba KASKAVALCİ
Institution: Istanbul University
Country: Turkey

Author: Erman Caner BULUT
Institution: Istanbul University
Country: Turkey

Institution: Istanbul University
Country: Turkey

Supporting Institution This study was funded by Scientific Research Projects Coordination Unit of Istanbul University
Project Number 27021 and 33876

Application Date : September 20, 2019
Acceptance Date : November 29, 2019
Publication Date : December 6, 2019

Bibtex @research article { iufsjb656148, journal = {European Journal of Biology}, issn = {2602-2575}, eissn = {2618-6144}, address = {}, publisher = {Istanbul University}, year = {2019}, volume = {78}, pages = {147 - 155}, doi = {}, title = {Effects of Tempol in Lipopolysaccharide-Induced Liver Injury}, key = {cite}, author = {Serin, Perihan Sinem and Kandil, Aslı and Bulut, Huri and Kaskavalci, Tugba and Bulut, Erman Caner and Demirci-tansel, Cihan} }
APA Serin, P , Kandil, A , Bulut, H , Kaskavalci, T , Bulut, E , Demirci-tansel, C . (2019). Effects of Tempol in Lipopolysaccharide-Induced Liver Injury . European Journal of Biology , 78 (2) , 147-155 . Retrieved from
MLA Serin, P , Kandil, A , Bulut, H , Kaskavalci, T , Bulut, E , Demirci-tansel, C . "Effects of Tempol in Lipopolysaccharide-Induced Liver Injury" . European Journal of Biology 78 (2019 ): 147-155 <>
Chicago Serin, P , Kandil, A , Bulut, H , Kaskavalci, T , Bulut, E , Demirci-tansel, C . "Effects of Tempol in Lipopolysaccharide-Induced Liver Injury". European Journal of Biology 78 (2019 ): 147-155
RIS TY - JOUR T1 - Effects of Tempol in Lipopolysaccharide-Induced Liver Injury AU - Perihan Sinem Serin , Aslı Kandil , Huri Bulut , Tugba Kaskavalci , Erman Caner Bulut , Cihan Demirci-tansel Y1 - 2019 PY - 2019 N1 - DO - T2 - European Journal of Biology JF - Journal JO - JOR SP - 147 EP - 155 VL - 78 IS - 2 SN - 2602-2575-2618-6144 M3 - UR - Y2 - 2019 ER -
EndNote %0 European Journal of Biology Effects of Tempol in Lipopolysaccharide-Induced Liver Injury %A Perihan Sinem Serin , Aslı Kandil , Huri Bulut , Tugba Kaskavalci , Erman Caner Bulut , Cihan Demirci-tansel %T Effects of Tempol in Lipopolysaccharide-Induced Liver Injury %D 2019 %J European Journal of Biology %P 2602-2575-2618-6144 %V 78 %N 2 %R %U
ISNAD Serin, Perihan Sinem , Kandil, Aslı , Bulut, Huri , Kaskavalci, Tugba , Bulut, Erman Caner , Demirci-tansel, Cihan . "Effects of Tempol in Lipopolysaccharide-Induced Liver Injury". European Journal of Biology 78 / 2 (December 2019): 147-155 .
AMA Serin P , Kandil A , Bulut H , Kaskavalci T , Bulut E , Demirci-tansel C . Effects of Tempol in Lipopolysaccharide-Induced Liver Injury. Eur J Biol. 2019; 78(2): 147-155.
Vancouver Serin P , Kandil A , Bulut H , Kaskavalci T , Bulut E , Demirci-tansel C . Effects of Tempol in Lipopolysaccharide-Induced Liver Injury. European Journal of Biology. 2019; 78(2): 147-155.
IEEE P. Serin , A. Kandil , H. Bulut , T. Kaskavalci , E. Bulut and C. Demirci-tansel , "Effects of Tempol in Lipopolysaccharide-Induced Liver Injury", European Journal of Biology, vol. 78, no. 2, pp. 147-155, Dec. 2019