Year 2020, Volume 79 , Issue 2, Pages 98 - 105 2020-12-25

Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities of Agropyron repens and Crataegus monogyna Species

Ebru DEVECI [1] , Gulsen TEL CAYAN [2] , Serdar KARAKURT [3] , Mehmet Emin DURU [4]


Objective: The aim of this study was to investigate antioxidant, enzyme inhibitory and cytotoxic activities of Agropyron repens and Crataegus monogyna methanol extracts with total phenolic and flavonoid contents. Materials and Methods: Total phenolic and flavonoid contents of A. repens and C. monogyna methanol extracts were measured according to Folin Ciocalteu and aluminum nitrate methods, respectively. Antioxidant and enzyme inhibitory activities of the methanol extracts were tested spectrophotometrically. Also, cytotoxic activities of the methanol extracts
against DLD-1 and CCD-18Co were investigated by using Alamar Blue assay. Results: C. monogyna methanol extract with the highest total phenolic and flavonoid contents (68.13±0.34 μg GAEs/mg extract and 36.91±0.17 μg QEs/mg extract, respectively) had the best antioxidant activity in β-carotene-linoleic acid (IC50: 32.72±0.15 μg/mL), CUPRAC (A0.50: 282.69±0.25 μg/mL), DPPH• (IC50: 71.69±0.85 μg/mL), and ABTS•+ (IC50: 40.43±0.55 μg/ mL) assays. A. repens methanol extract showed the highest effect against AChE (18.73±0.47 %), BChE (37.59±1.07 %), urease (89.18±0.84%), α-glucosidase (6.71±0.23 %), whereas C. monogyna methanol extract showed the highest effect against tyrosinase (30.52±1.00%) and α-amylase (37.24±0.06 %). Also, A. repens (IC50: 57.38 μg/mL) and C. monogyna (IC50: 54.04 μg/ mL) methanol extracts showed close cytotoxic activity on DLD-1. Conclusion: Antioxidant, cytotoxic, and enzyme inhibitory activities of A. repens and C. monogyna methanol extracts were investigated with total phenolic and flavonoid contents in this study. The results obtained with this study strengthen the potential of the studied plants as a new source for the discovery of antioxidant, cytotoxic, and enzyme inhibitor agents.
Agropyron repens, Crataegus monogyna, antioxidant activity, cytotoxic activity, enzyme inhibitory activity
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Primary Language en
Subjects Science
Journal Section Research Articles
Authors

Orcid: 0000-0002-2597-9898
Author: Ebru DEVECI (Primary Author)
Institution: Konya Technical University
Country: Turkey


Orcid: 0000-0002-1916-7391
Author: Gulsen TEL CAYAN
Institution: Muğla Sıtkı Koçman University
Country: Turkey


Orcid: 0000-0002-4449-6103
Author: Serdar KARAKURT
Institution: SELCUK UNIVERSITY
Country: Turkey


Orcid: 0000-0001-7252-4880
Author: Mehmet Emin DURU
Institution: Muğla Sıtkı Koçman University
Country: Turkey


Supporting Institution There are no funders to report for this submission.
Thanks Authors would like to thank Dr. Ergün Kaya (Faculty of Science, Department of Molecular Biology and Genetics, Muğla Sıtkı Koçman University) for the identification of the plant samples.
Dates

Application Date : October 27, 2020
Acceptance Date : June 18, 2021
Publication Date : December 25, 2020

Bibtex @research article { iufsjb844411, journal = {European Journal of Biology}, issn = {2602-2575}, eissn = {2618-6144}, address = {}, publisher = {Istanbul University}, year = {2020}, volume = {79}, pages = {98 - 105}, doi = {}, title = {Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities of Agropyron repens and Crataegus monogyna Species}, key = {cite}, author = {Devecı, Ebru and Tel Cayan, Gulsen and Karakurt, Serdar and Duru, Mehmet Emin} }
APA Devecı, E , Tel Cayan, G , Karakurt, S , Duru, M . (2020). Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities of Agropyron repens and Crataegus monogyna Species . European Journal of Biology , 79 (2) , 98-105 . Retrieved from https://dergipark.org.tr/en/pub/iufsjb/issue/55111/844411
MLA Devecı, E , Tel Cayan, G , Karakurt, S , Duru, M . "Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities of Agropyron repens and Crataegus monogyna Species" . European Journal of Biology 79 (2020 ): 98-105 <https://dergipark.org.tr/en/pub/iufsjb/issue/55111/844411>
Chicago Devecı, E , Tel Cayan, G , Karakurt, S , Duru, M . "Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities of Agropyron repens and Crataegus monogyna Species". European Journal of Biology 79 (2020 ): 98-105
RIS TY - JOUR T1 - Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities of Agropyron repens and Crataegus monogyna Species AU - Ebru Devecı , Gulsen Tel Cayan , Serdar Karakurt , Mehmet Emin Duru Y1 - 2020 PY - 2020 N1 - DO - T2 - European Journal of Biology JF - Journal JO - JOR SP - 98 EP - 105 VL - 79 IS - 2 SN - 2602-2575-2618-6144 M3 - UR - Y2 - 2021 ER -
EndNote %0 European Journal of Biology Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities of Agropyron repens and Crataegus monogyna Species %A Ebru Devecı , Gulsen Tel Cayan , Serdar Karakurt , Mehmet Emin Duru %T Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities of Agropyron repens and Crataegus monogyna Species %D 2020 %J European Journal of Biology %P 2602-2575-2618-6144 %V 79 %N 2 %R %U
ISNAD Devecı, Ebru , Tel Cayan, Gulsen , Karakurt, Serdar , Duru, Mehmet Emin . "Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities of Agropyron repens and Crataegus monogyna Species". European Journal of Biology 79 / 2 (December 2020): 98-105 .
AMA Devecı E , Tel Cayan G , Karakurt S , Duru M . Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities of Agropyron repens and Crataegus monogyna Species. Eur J Biol. 2020; 79(2): 98-105.
Vancouver Devecı E , Tel Cayan G , Karakurt S , Duru M . Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities of Agropyron repens and Crataegus monogyna Species. European Journal of Biology. 2020; 79(2): 98-105.
IEEE E. Devecı , G. Tel Cayan , S. Karakurt and M. Duru , "Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities of Agropyron repens and Crataegus monogyna Species", European Journal of Biology, vol. 79, no. 2, pp. 98-105, Dec. 2020