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Year 2023, Volume: 82 Issue: 1, 95 - 108, 26.06.2023
https://doi.org/10.26650/EurJBiol.2023.1240220

Abstract

References

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The Role of Akt Signalling Pathway in Neurological and Cardiovascular Pathologies

Year 2023, Volume: 82 Issue: 1, 95 - 108, 26.06.2023
https://doi.org/10.26650/EurJBiol.2023.1240220

Abstract

The PI3K/Akt/mTOR signalling pathway plays a crucial role in several biological processes, including cell proliferation, survival, and apoptosis, as well as regulates numerous signalling pathways, including JNK, NF-đťś…B, and ERK pathways. The recent proliferation of signal transduction studies in neurological and cardiovascular diseases/injuries sheds light on Akt-dependent pathogenesis. The downregulation of the Akt signalling pathway 24 hours post-injury prevents neurogenesis and promotes the progression of severe secondary injuries, including neuroinflammation, scar formation, and neuronal and glial necrosis, following traumatic brain and spinal cord injury, suggesting designing therapeutic approaches within a 24-hour window postinjury. Similarly, the downregulation of the Akt signalling pathway in myocardial infarction lowers cardiovascular protection, limits neurovascularization, and inhibits cell survival. Following myocarditis, the Akt signalling network is upregulated, leading to aggravated inflammation, and increased myocardial damage. Also, the upregulation of the PI3K/Akt/mTOR pathway in chordoma promotes tumor progression and invasion, leading to neuronal damage and impaired physiological functions. Future therapeutics that target the aberrant expression of key players in the PI3K/Akt/mTOR signalling pathway present a promising approach to treating several neurological and cardiovascular pathologies. This narrative review discusses the role of PI3K/Akt/mTOR signalling pathway in traumatic central nervous system injuries (brain and spinal cord), cardiac injury (myocardial infarction), inflammatory disease (myocarditis), and rare neurological cancer (chordoma) along with therapeutic targets that are known to prevent worsened outcomes and promote recovery following those conditions.

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There are 113 citations in total.

Details

Primary Language English
Subjects Structural Biology
Journal Section Review
Authors

Akshat Modi 0000-0003-1086-3670

Aahmad Mahoon This is me 0000-0002-6850-3910

Dharmeshkumar Modi This is me 0000-0002-4011-0533

Publication Date June 26, 2023
Submission Date January 21, 2023
Published in Issue Year 2023 Volume: 82 Issue: 1

Cite

AMA Modi A, Mahoon A, Modi D. The Role of Akt Signalling Pathway in Neurological and Cardiovascular Pathologies. Eur J Biol. June 2023;82(1):95-108. doi:10.26650/EurJBiol.2023.1240220