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Effect of Adriamycin Administered via Different Routes on Ehrlich Ascites Tumor Cells

Year 2008, Volume: 67 Issue: 1, 49 - 54, 17.11.2010

Abstract

 

Adriamycin (ADR) is an antineoplastic drug, isolated from Streptomyces peucetius var. caesius, and has cytotoxic features. It binds DNA by intercalation and inhibits replication and transcription. Clinically, ADR is used intravenously and intravesically. Ehrlich ascites tumor (EAT) was originated from breast carcinoma in a mouse. It grows in solid and ascitic forms. The aim of our study is to investigate the effectiveness of ADR on mice bearing EAT by comparing its administration routes. 0.01 mg.g-1 ADR was administered mice bearing EAT via intraperitoneal, intravenous and subcutaneous. On day 0 each mouse in the experiment was inoculated with 3x105 EAT cells. On the 2nd, 4th, 6th, 8th days after administration, number of viable cells and mitosis number were counted from each animal by drainage the ascites fluid from the peritoneal cavity of each mouse. Data were evaluated statistically. The most efficient in respect of curing properties was observed in group I in which ADR administered via intraperitoneal.

References

  • Arcamone F., Cassinelli G., Fantini G., Grein A., Orezzi P., Pol C. and Spalla C. (1969) 14- Hydroxydaunomycin, a new antibiotic from Streptomyces Biotechnology and Bioengineering, 11: 1101- 1110. var. caesius.
  • Asaumi J., Nishikawa K., Matsuoka H., Iwata M., Kawasaki S., Hiraki Y. and Nishijima K. (1995) Direct antitumor effect of cepharantin and combined effect with adriamycin against Ehrlich ascites tumor in mice. Anticancer Research, 15 (1): 67-70.
  • Bancroft J.D., Stevens A. and Turner D.R. (1990) Theory and Practice of Histological Techniques. 3rd Edn., Longman Group UK Limited, Great Britain, pp:37, 148-189.
  • Barranco S.C., Gerner E.W., Burk K.H. and Humphrey R.M. (1973) Survival and cell kinetics effects of adriamycin on mammalian cells. Cancer Research., 33: 11-16.
  • Booser D.J. and Hortobagyı G.N. (1994) Anthracycline antibiotics in cancer therapy. Drugs, 47 (2): 223-258.
  • Bowers D.G. and Lynch J.B. (1978) Adriamycin extravasation. Surgery, 61 (1): 86-92. & Reconstructive
  • Ivic M.A., Petrovic S.D., Kalman E., Milosavljevic T., Reljin I., Reljin B., Bogdanovic G., Baltic V.V. and Keresztes Z. (2005) AFM studies of DNA structures extracted from adriamycin treated and non-treated Ehrlich tumor cells. Journal of Serbian Chemical Society, 70 (6): 823-831.
  • Kaleoğlu Ö. and İşli N. (1977) Ehrlich-Lettré Asit Tümörü. İstanbul Üniversitesi Tıp Fakültesi Mecmuası, 40: 978-984.
  • Kayaalp, O. (1996) Tıbbi Farmakoloji, 2nd Edn, Hacettepe Taş Kitapçılık, Ankara, ISBN: 975- 7731-23-4, pp.79.
  • Kim, S.H., Kim, J.H. (1972) Lethal effect of Adriamycin on the division cycle of HeLa cells. Cancer Research, 32: 323-325.
  • Lefrak, E.A., Pitha, J., Rosenheim, S. and Gottlieb, J.A. (1973) A clinicopathologic analysis of adriamycin cardiotoxicity. Cancer, 32:302-314.
  • Luedke, D.W., Kennedy, P.S. and Rietschel, R.L. (1979) subcutaneous injury induced by adriamycin. Plastic & Reconstructive Surgery, 63 (4): 463- 465. of skin and
  • Malviya, V.K., Deppe, G., Boike, G. and Young, J. (1990) Pharmacokinetics of intraperitoneal doxorubicin in combination with systemic cyclophosphamide and cis-platinum in the treatment Gynecologic Oncology, 36: 185-188. III ovarian cancer.
  • Mazzotta, P., Kwasnicka, A. and Kutas, G.J. (2001) Cancer pharmacological agents in the management of haematological malignancies. University of Toronto Medical Journal, 79 (1): 38-45. of
  • Mimaki Y., Shinozawa S., Yasuda K., Yao K., Etwo K., Fukuda T. and Araki Y. (1982) Antitumor effect of water-in-oil-in-water type adriamycin emulsion on Ehrlich solid tumor-bearing mice. Gan To Kagaku Rhoyo, 9 (3): 467-472.
  • Momparler R.L., Karon M., Siegel S.E. and Avila F. (1976) Effects of adriamycin on DNA, RNA and protein synthesis in cell-free systems and intact cells. Cancer Research., 36: 2891-2895.
  • Muggia F.M. and Green M.D. (1991) New anthracycline antitumor antibiotics. Critical Reviews in Oncology/Hematology, 11:43-64.
  • Musa, D., Dilsiz, N., Gumushan, H., Ulakoglu, G. and Bitiren, M. (2004) Antitumor activity of an ethanolic extract of Nigella sativa seeds. Biologia, Bratislava, 59 (6): 735-740.
  • Musa D., Dilsiz N., Gümüşhan H. and Özardalı İ. (2004) Adriamycin toksisitesine karşı Nigella sativa ekstraktının etkisi. XVII. Ulusal Biyoloji Kongresi 2. Seksiyon Bildiri Özetleri Kitabı pp:42, Adana.
  • Myers C.E., McGuire W.P., Liss R.H., Ifrim I., Grotzinger K. and Young R.C. (1977) Adriamycin: The role of lipid peroxidation in cardiac toxicity and tumor response. Science, 197 (4299): 165-167.
  • Olson R.D. and Mushlin P.S. (1990) Doxorubicin cardiotoxicity: hypotheses. The FASEB Journal, 4: 3076-3086. of prevailing
  • Ommaty R. (2001) Vademecum. 20th Edn, Hacettepe Taş Kitapçılık, Ankara, ISBN:8506- 02-1, pp.229.
  • Öz E. and İlhan M.N. (2006) Effects of melatonin in reducing in the toxic effects of doxorubicin. Molecular and Cellular Biochemistry, 286: 11- 15.
  • Rajagopalan S., Politi P.M., Sinha B.K. and Myers E. 1988. Adriamycin induced free radical formation in the perfused rat heart: implications for cardiotoxicity. Cancer Research, 48 (17): 4766-4769.
  • Shimpo K., Nagatsu T., Yamada K., Sato T., Niimi H., Shamoto M., Takeuchi T., Umezawa H. and Fujita K. (1991) Ascorbic acid and adriamycin toxicity. The American Journal of Clinical Nutrition, 54: 1298S-1301S.
  • Sugiyama M., Sakanashi T., Okamoto K., Chinami M., Hidaka T. and Ogura R. (1986) Membrane fluidity in Ehrlich ascites tumor cells treated with adriamycin. Biotechnology and Applied Biochemistry, 8 (2-3): 217-221.
  • Şen S.C. (1999) Adriamycin ekstravazasyonuna bağlı cilt yaralanmalarının önlenmesinde vitamin C kullanımı: Deneysel çalışma. Tıpta Uzmanlık Tezi, U.Ü., Tıp Fak., Plastik ve Rekonstrüktif Cerrahi ABD., Bursa.
  • Wang J.J., Cortes E., Sinks L.F. and Holland J.F. (1971) Therapeutic effect and toxicity of Adriamycin in patients with neoplastic disease. Cancer, 28: 837-843.
  • Wang Y.M., Madanat F.F., Kimball J.C., Gleiser C.A., Ali M.K., Kaufman M.W. and Eys J.V. (1980) Effect of vitamin E against ADR- induced toxicity in rabbits. Cancer Research, 40: 1022-1027.
Year 2008, Volume: 67 Issue: 1, 49 - 54, 17.11.2010

Abstract

References

  • Arcamone F., Cassinelli G., Fantini G., Grein A., Orezzi P., Pol C. and Spalla C. (1969) 14- Hydroxydaunomycin, a new antibiotic from Streptomyces Biotechnology and Bioengineering, 11: 1101- 1110. var. caesius.
  • Asaumi J., Nishikawa K., Matsuoka H., Iwata M., Kawasaki S., Hiraki Y. and Nishijima K. (1995) Direct antitumor effect of cepharantin and combined effect with adriamycin against Ehrlich ascites tumor in mice. Anticancer Research, 15 (1): 67-70.
  • Bancroft J.D., Stevens A. and Turner D.R. (1990) Theory and Practice of Histological Techniques. 3rd Edn., Longman Group UK Limited, Great Britain, pp:37, 148-189.
  • Barranco S.C., Gerner E.W., Burk K.H. and Humphrey R.M. (1973) Survival and cell kinetics effects of adriamycin on mammalian cells. Cancer Research., 33: 11-16.
  • Booser D.J. and Hortobagyı G.N. (1994) Anthracycline antibiotics in cancer therapy. Drugs, 47 (2): 223-258.
  • Bowers D.G. and Lynch J.B. (1978) Adriamycin extravasation. Surgery, 61 (1): 86-92. & Reconstructive
  • Ivic M.A., Petrovic S.D., Kalman E., Milosavljevic T., Reljin I., Reljin B., Bogdanovic G., Baltic V.V. and Keresztes Z. (2005) AFM studies of DNA structures extracted from adriamycin treated and non-treated Ehrlich tumor cells. Journal of Serbian Chemical Society, 70 (6): 823-831.
  • Kaleoğlu Ö. and İşli N. (1977) Ehrlich-Lettré Asit Tümörü. İstanbul Üniversitesi Tıp Fakültesi Mecmuası, 40: 978-984.
  • Kayaalp, O. (1996) Tıbbi Farmakoloji, 2nd Edn, Hacettepe Taş Kitapçılık, Ankara, ISBN: 975- 7731-23-4, pp.79.
  • Kim, S.H., Kim, J.H. (1972) Lethal effect of Adriamycin on the division cycle of HeLa cells. Cancer Research, 32: 323-325.
  • Lefrak, E.A., Pitha, J., Rosenheim, S. and Gottlieb, J.A. (1973) A clinicopathologic analysis of adriamycin cardiotoxicity. Cancer, 32:302-314.
  • Luedke, D.W., Kennedy, P.S. and Rietschel, R.L. (1979) subcutaneous injury induced by adriamycin. Plastic & Reconstructive Surgery, 63 (4): 463- 465. of skin and
  • Malviya, V.K., Deppe, G., Boike, G. and Young, J. (1990) Pharmacokinetics of intraperitoneal doxorubicin in combination with systemic cyclophosphamide and cis-platinum in the treatment Gynecologic Oncology, 36: 185-188. III ovarian cancer.
  • Mazzotta, P., Kwasnicka, A. and Kutas, G.J. (2001) Cancer pharmacological agents in the management of haematological malignancies. University of Toronto Medical Journal, 79 (1): 38-45. of
  • Mimaki Y., Shinozawa S., Yasuda K., Yao K., Etwo K., Fukuda T. and Araki Y. (1982) Antitumor effect of water-in-oil-in-water type adriamycin emulsion on Ehrlich solid tumor-bearing mice. Gan To Kagaku Rhoyo, 9 (3): 467-472.
  • Momparler R.L., Karon M., Siegel S.E. and Avila F. (1976) Effects of adriamycin on DNA, RNA and protein synthesis in cell-free systems and intact cells. Cancer Research., 36: 2891-2895.
  • Muggia F.M. and Green M.D. (1991) New anthracycline antitumor antibiotics. Critical Reviews in Oncology/Hematology, 11:43-64.
  • Musa, D., Dilsiz, N., Gumushan, H., Ulakoglu, G. and Bitiren, M. (2004) Antitumor activity of an ethanolic extract of Nigella sativa seeds. Biologia, Bratislava, 59 (6): 735-740.
  • Musa D., Dilsiz N., Gümüşhan H. and Özardalı İ. (2004) Adriamycin toksisitesine karşı Nigella sativa ekstraktının etkisi. XVII. Ulusal Biyoloji Kongresi 2. Seksiyon Bildiri Özetleri Kitabı pp:42, Adana.
  • Myers C.E., McGuire W.P., Liss R.H., Ifrim I., Grotzinger K. and Young R.C. (1977) Adriamycin: The role of lipid peroxidation in cardiac toxicity and tumor response. Science, 197 (4299): 165-167.
  • Olson R.D. and Mushlin P.S. (1990) Doxorubicin cardiotoxicity: hypotheses. The FASEB Journal, 4: 3076-3086. of prevailing
  • Ommaty R. (2001) Vademecum. 20th Edn, Hacettepe Taş Kitapçılık, Ankara, ISBN:8506- 02-1, pp.229.
  • Öz E. and İlhan M.N. (2006) Effects of melatonin in reducing in the toxic effects of doxorubicin. Molecular and Cellular Biochemistry, 286: 11- 15.
  • Rajagopalan S., Politi P.M., Sinha B.K. and Myers E. 1988. Adriamycin induced free radical formation in the perfused rat heart: implications for cardiotoxicity. Cancer Research, 48 (17): 4766-4769.
  • Shimpo K., Nagatsu T., Yamada K., Sato T., Niimi H., Shamoto M., Takeuchi T., Umezawa H. and Fujita K. (1991) Ascorbic acid and adriamycin toxicity. The American Journal of Clinical Nutrition, 54: 1298S-1301S.
  • Sugiyama M., Sakanashi T., Okamoto K., Chinami M., Hidaka T. and Ogura R. (1986) Membrane fluidity in Ehrlich ascites tumor cells treated with adriamycin. Biotechnology and Applied Biochemistry, 8 (2-3): 217-221.
  • Şen S.C. (1999) Adriamycin ekstravazasyonuna bağlı cilt yaralanmalarının önlenmesinde vitamin C kullanımı: Deneysel çalışma. Tıpta Uzmanlık Tezi, U.Ü., Tıp Fak., Plastik ve Rekonstrüktif Cerrahi ABD., Bursa.
  • Wang J.J., Cortes E., Sinks L.F. and Holland J.F. (1971) Therapeutic effect and toxicity of Adriamycin in patients with neoplastic disease. Cancer, 28: 837-843.
  • Wang Y.M., Madanat F.F., Kimball J.C., Gleiser C.A., Ali M.K., Kaufman M.W. and Eys J.V. (1980) Effect of vitamin E against ADR- induced toxicity in rabbits. Cancer Research, 40: 1022-1027.
There are 29 citations in total.

Details

Primary Language English
Journal Section Makaleler
Authors

Hatice Gümüşhan

Davut Musa This is me

Publication Date November 17, 2010
Submission Date November 17, 2010
Published in Issue Year 2008 Volume: 67 Issue: 1

Cite

AMA Gümüşhan H, Musa D. Effect of Adriamycin Administered via Different Routes on Ehrlich Ascites Tumor Cells. Eur J Biol. November 2010;67(1):49-54.