BOUGIE DILATATION IN BENIGN ESOPHAGEAL STRICTURES: EVALUATION OF ADJUVANT METHYLPREDNISOLONE INJECTION

Abstract

Objective: Mechanical dilatation and adjuvant injection of triamcinolone acetate (TA) effectively preserve the opening provided and reduce the number of bougie dilation (BD) in benign esophageal strictures. In this study, we aimed to evaluate the role of Methylprednisolone (MP) injection after BD in providing permanent/long-term lumen opening.
Materials and Methods: Among 22 patients diagnosed with benign esophageal strictures (BES) between January 2017 and October 2020, we evaluated the results of 8 patients who continued the endoscopic follow-up program and underwent BD and MP injection, then compared with the literature.
Results: We treated 8 patients [6 (75%) women, mean age 61±16.9 years (range 22-77)] with strictures of different etiologies (3 anastomotic, 2 iatrogenic esophageal rupture repairs, 2 recurrent webs, and 1 scleroderma) with BD followed by intralesional MP injection. We performed median BD sessions 3.5 times (range 1-8). We gave a median 3 intralesional MP injection (range 1-7). The median time to resolve stricture was 2.5 months (range 1-4). The median endoscopic follow-up time was 4.5 months (range 1-17).
Conclusions: Adjuvant MP injection is successful in preserving the lumen patency provided after mechanical dilatation. Randomized controlled studies are needed to determine the steroid type and dose to provide the most optimal permanent lumen opening with lesser dilatation sessions in BES.

Keywords

• Benign esophageal stricture
• bougie dilation
• endoscopic therapy
• Methylprednisolone

Project Number

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BENİGN ÖZOFAGEAL STRİKTÜRLERDE BUJİ DİLATASYONU: ADJUVAN METİLPREDNİZOLON İNJEKSİYONUNUN DEĞERLENDİRİLMESİ

Abstract

Amaç: Benign özofageal striktürklerde mekanik dilatasyon sonrası adjuvan triamsinolon asetat (TA) injeksiyonu bujilerle sağlanan açıklığın korunmasında ve buji dilatasyon (BD) seans sayısını azaltmada etkilidirler. Bu çalışmada, buji dilatasyonu sonrasında Metilprednizolon (MP) injeksiyonunun kalıcı/uzun dönem lümen açıklığını sağlamadaki etkinliğini araştırmayı planladık.
Gereç ve Yöntem: Ocak 2017-Ekim 2020 tarihleri arasında benign özofageal darlık (BES) tanısı alan 22 hasta arasından BD ve MP injeksiyon seanslarına alınan ve endoskopik takip programına devam eden 8 hastanın sonuçlarını değerlendirerek literatürle karşılaştırdık.
Bulgular: Farklı etyolojik nedenlere (3 anastomotik, 2 iatrojenik özofageal rüptür onarımı, 2 rekürren web ve 1 skleroderma) bağlı striktürleri olan 8 hastayı [6 (75%) kadın, yaş ortalaması 61±16,9 yıl, (22-77)] buji dilatasyonu ve takiben intralezyonel MP injeksiyonu ile tedavi ettik. Kalıcı açıklığın sağlanması için median BD seans sayısını 3,5 (1-8) saptadık. İntralezyonel olarak uyguladığı- mız median MP injeksiyonu sayısı 3 (1-7) oldu. Striktürlerin medi- an düzelme zamanı 2,5 aydı (1-4). Hastaların median endoskopik takip sürelerini ise 4,5 ay (1-17) olarak belirledik.
Sonuçlar: Mekanik dilatasyon sonrasında sağlanan lümen açıklığının korunmasında adjuvan MP injeksiyonu başarılıdır. Benign özofageal striktürlerde en az dilatasyon sayısı ile optimal kalıcı lümen açlıklığını sağlamada kullanılacak steroid tipi ve dozunu belirlemede randomize kontrollü çalışmalara ihtiyaç vardır.

Keywords

• Benign özofageal striktür
• buji dilatasyonu
• endoskopik tedavi
• metilprednizolon

Supporting Institution

Yok

Project Number

Yok

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