OBEZ ÇOCUKLARDAPLAZMAGHRELİN, SERUM IGF-I VE IGFBP-3 DÜZEYLERİ

Abstract

Amaç: Günümüzde obesite bir çok metabolik ve hormonal bozukluğa sebep olan bir hastalık olarak kabul edilmektedir. Obez kişilerde kilo alımının nedenlerinin ve patofizyolojik sonuçlarının anlaşılması, obesiteyi önleyici etkintedavi ve korunma yöntemlerinin gelişmesine katkı sağlayabilir. Bu çalışmada, obez çocuklarda ghrelin düzeylerini ve büyüme faktörleri olan IGF-1 ve IGFBP-3 ile ilişkisini araştırdık. Gereç ve yöntem: 38 obez ve 19 sağlıklı çocuk çalışmaya dahil edilmiştir. Çalışmaya alınan olguların açlık ve tokluk ghrelin, IGF-I, IGFBP-3 düzeyleri ölçülmüştür.Bulgular: Normal çocuklara kıyasla, obez olguların plazma ghrelin düzeyleri düşük, IGF-I ve IGFBP–3 düzeyleri ise yüksek bulundu (p

Keywords

• Obezite, ghrelin, IGF-I, IGFBP-3, çocuk

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