AİLESEL AKDENİZ ATEŞİ'NDE BÖBREK TUTULUMU

Abstract

Ailesel Akdeniz Ateşi (AAA), otozomal resesif geçiş gösteren, tekrarlayan ateş, peritonit, plörit ve sinovit atakları ile karakterize kalıtımsal bir hastalıktır. AAA’nin en önemli özelliğinden birisi sistemik amiloidoz ve amiloidoz dışı diğer böbrek patolojilerine neden olmasıdır. AAA ile ilişkili amiloidoz, başlangıçta proteinüri ile kendini gösterir, nefrotik sendrom ve böbrek yetmezliğine kadar ilerleyebilir. Son 30 yılda hastalığa erken tanı koymak ve kolşisinle erken tedaviye başlamakla, AAA ile ilişkili amiloidoz insidansı giderek azalmıştır.

Keywords

• Ailesel akdeniz ateşi, böbrek

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