HEMATOPOETİK KÖK HÜCRE NAKLİ VE SİTOMEGALOVİRÜS İNFEKSİYONU: DEĞİŞEN KLİNİK, TANI VE TEDAVİ

Abstract

Sitomegalovirus (CMV) enfeksiyonu hematopoetik kök hücre naklinden sonra morbidite ve mortalitenin önemli bir nedeni olarak yer almaktadır. Günümüzde CMV patogenezinin anlaşılması ve gelişen modern laboratuvar teknikleri ile virüsün erken tespiti ve uygun antiviral ile tedavisinde önemli ilerlemeler kaydedilmiştir. CMV infeksiyonu için yüksek riskli kök hücre alıcılarının belirlenmesi ve bunların gansiklovir ile profilaktik olarak (nakilden sonra engrafmandan başlayarak 100.güne kadar) veya preemptif (CMV infeksiyonu tespit edildikten sonra hastalığın gelişmesinin önlenmesi) tedavisi bu yazıda önemli çalışmalar ışığında özetlenmiştir.

Keywords

• Kök hücre nakli, sitomegalovirüs, gansiklovir

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