NAZOFARENGEAL KARSİNOMLU 100 HASTANIN RETROSPEKTİF ANALİZİ

Abstract

Amaç: Bu retrospektiv çalışmanın amacı, nonmetastatik nazofarengeal karsinomlu 100 hastanın survi ve rekürrens paternini analiz etmekti. Gereç ve yöntem: 1991-2003 yılları arasında tedavi edilen 100 nazofarengeal karsinomlu hasta retrospektif olarak incelendi. 24’ü yalnız radyoterapi ile tedavi edilirken, 76’sına kombine model tedavi (cisplatin bazlı 2-4 kür neoadjuvant kemoterapi ve radyoterapi) uygulanmıştı. Nazofarengeal bölgeye 66-70 Gy, lenf nodlarına 50 Gy, servikal hastalık mevcut ise tutulan alana 15-20 Gy boost dozu verilmişti. Bulgular: AJCC 1997 evreleme sistemine göre, hastaların 20’si evre II, 47’si evre III, 33’ü evre IV’tü. Tüm hastalar skuamoz hücreli nazofarengial karsinom tanısı almıştı (18 WHO I-II, 82 WHO III). Minimum takip süresi 2 yıldı. İndüksiyon kemoterapisine yanıt oranı %75 (%13,2 tam ve %61,8 kısmi), yanıtsız olanların oranı (progresif hastalık) %7,9 ve stabil hastalık oranı %17,1’di. Radyoterapi sonrası başarısızlık oranı %53’tü. Bunların %56,6’sı lokoregional nüks, %28,3’ü lokoregional nüks ve uzak metastaz ve %15,1’i izole metastazdı. 5 yıllık genel sağ kalım yalnız radyoterapi verilenlerde %57,1, kombine tedavi verilenlerde %57,7 idi. Sonuç: İndüksiyon kemoterapisi nazofarengeal karsinomlu hastalarda tedavi sonuçlarını ve başarısızlık paternini değiştirmemiştir.

Keywords

• Nazofarengeal karsinoma, radyoterapi, kemoterapi, sürvi

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