BİTKİSEL FLAVONOİD BİLEŞİKLERİNİN BİYOAKTİVİTELERİ VE MUHTEMEL ETKİ MEKANİZMALARI - BIOACTIVITIES OF PLANT FLAVONOIDS AND THE POSSIBLE ACTION MECHANISMS

Abstract

Flavonoidler çoğu bitkilerde bulunan düşük moleküler ağırlıklı polifenolik bileşiklerdir. Özellikle bitkilerdeki yeşil, turuncu, kırmızı pigmentlerden sorumlu yapılar olarak tanımlanırlar. İn vivo, in vitro ve epidemiyolojik çalışmalarla tespit edilmiş birçok biyoaktiviteleri bildirilmektedir. Kardiyovasküler sistem üzerine olan aktiviteleri en çok üzerinde durulan etkileridir. Bunun yanında  serbest radikal uzaklaştırıcı (antioksidan) anti-trombotik, antihipertansif ,antiallerjik, antiinflamatuar, antiapoptotik ve son zamanlarda da antikanserojen aktiviteleri üzerinde çalışmalar devam etmektedir. Ayrıca flavonoidler çeşitli mekanizmalarla vasodilatator etkilidirler ve bu aktiviteleri endotelyuma bağımlı veya endotelyumdan bağımsız bir tarzdadır. Özellikleiskemi - reperfüzyon hasarında farklı birçok mekanizma ile flavonoidlerin koruyucu aktiviteleri ileri sürülmektedir.Bu derlemede flavonoidlerin kardiyoprotektif aktivitelerindeki  muhtemel etki mekanizmalarını ele alındı.

Anahtar Kelimeler: Flavonoid bileşikleri; antioksidan; iskemi- reperfüzyon; biyoaktivite

Keywords

• Flavonoid bileşikleri, antioksidan, iskemi- reperfüzyon,biyoaktivite

References

1. Achike FI, Kwan CY. Nitric oxide human diseases and the herbal products that effect the nitric oxide signaling pathway. Clin Exp Pharmacol Physiol. 2003;30(9):605-615
2. Ashraf M, Samra ZQ. Subcellular distribution of xanthine oxidase during cardiac ischemia and reperfusion :an immunocytochemical study. J Submicrosc Cytol Pathol 1993; 25: 193-201
3. Birman H,Tamer Ş, Melikoğlu G,Meriçli AH. Hypotensive activity of Crataegus tanacetifolia. İstanbul Ecz Fak Mecm 2001; 34: 23-26
4. Birman H, Akgün–Dar K, Kapucu A, Olgaç V, Gürel E. Deneysel hipertansif sıçanlarda Crataegus tanacetifolia (alıç) ve hiperozid’in tükürük bezi ile böbrek dokusu üzerine etkileri ve nitrik oksit (NO) ile ilişkisi. Nobel Med 2011; 7: 17-22.
5. Birman H, Akgün-Dar K, Kapucu A, Acar S, Üzüm G. Effects of Luteolin on liver, kidney and brain in PTZinduced Seizures: Involvement of metalloproteinases and NOS activities. Balkan Med Jour 2012; 29:2
6. Boadi WY, Iyere PA, Adunyah SE. In vitro exposure to quercetin and genistein alters lipit peroxides and prevents the loss of glutatione in human progenitor mononuclear (U937) cells. J Appl Toxicol 2005; 25: 82-88
7. Chen JX, Zeng H, Tou QH, Yu H, Meyrick B, Aschner JL. NADPH oxidase modulates myocardial Akt, ERK1/2 activation and angiogenesis after hypoxia –reoxygenation. Am J Physiol Heart Circ Physiol 2007; 292 : 1664-1674
8. Chen CK, Pace-Asciak CR. Vasorelaxing activity of resveratrol and quercetin in isolated rat aorta . Gen Pharmacol 1996; 27: 363-366

9. Cheng IF, Breen K. On the ability of four flavonoids baicilein, luteolin, naringenin and quercetin, to supress the Fenton reaction of the iron-ATP complex. Biometals 2000; 13:77-83
10. Cho JY, Kim IS, Jang YH, Kim AR, Lee SR. Protective effect of Quercetin, A natural flavonoid Against Neuronal damage after transient Global Cerebral Ischemia. Neurosci Lett 2006; 404: 330-335
11. Chun OK, Kim DO, Lee CY. Superoxide radical scavenging activity of the major polyphenols in fresh plums. J Agric Food Chem 2003 ;51: 8067-8072
12. Depeint F, Gee JM, Williamson G, Johnson IT. Evidence for consistent patterns between flavonoid structures and cellular activities. Proceeding Nutrition Society 2002;6 :97-103
13. Falchi M, Bertelli A, Lo Scalzo R, Morassut M, Morelli R, Das S, Cui J, Das DK. Comparison of cardioprotective abilities between the flesh and skin of grapes. J Agric Food Chem 2006; 54: 6613-6632
14. Falk JA, Aune SE, Kutala VK, Kuppusamy P, Angelos MG. Inhibition of peroxynitrite precursors, NO and O2 at the onset of reperfusion improves myocardial recovery. Resuscitation 2007; 74:508-515
15. Hertog MGL, Feskens EJM, Hollman PCH, Katan MB, Kromhout D. Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet 1993;342:1007-1011
16. Huk I, Brovkovych V, Nanobash Vili J, Weigel G, Neumayer C, Partyka L, Patton S, Malınskı T. Bioflavonoid quercetin scavenges superoxide and increases nitric oxide concentration in ischaemia-reperfusion injury: an experimental study. Br J Surg 1998; 85: 1080-1085
17. Ikizler M, Erkasap N, Dernek S, Kural T, Kaygisiz Z. Dietary polyphenol quercetin protects rats hearts during reperfusion: enhanced antioxidant capacity with chronic treatment. Anadolu Kardiol Derg 2007; 7: 404-410
18. Jochmann N, Lorenz M, Krosigk A, Martus P, Böhm V, Baumann G, Stangl K, Stangl V. The efficacy of black tea in ameliorating endothelial function is equivalent to that of green tea. Br J Nutr 2008 ;99: 863-868
19. Koçyıldız ZÇ, Birman H, Olgaç V, Akgün-Dar K, Melikoğlu G,Meriçli A.H. Crataegus tanacetifolia leaf extract prevents L-NAME-induced hypertension in rats: A morphological study. Phytotherapy Res 2006; 20 : 66-70
20. Looi YH, Grieve DJ, Siva A, Walker SJ, Anilkumar N, Cave AC, Marber M. Involvement of NOX2 NADPH oxidase in adverse cardiac remodeling after myocardial infarction. Hypertension 2008;51: 319-325
21. Maffei Facino R,Carini M, Aldini G, Berti F, Rossoni G, Bombardellio E, Morazzonio P. Diet enriched with procyanidins enhances antioxidant activity and reduces myocardial post ischaemic damage in rats. Life Sci 1999; 64: 627-642
22. Malemud CJ. Matrix metalloproteinases (MMP’s) in healty and disease: an overview. Front Biosci 2006; 11: 1696-1701
23. Mc Carty MF. Scavenging of peroxynitrite-derivated radicals by flavonoids may support endothelial NO synthase activity, contributing to the vascular protection associated with high fruit and vegetables intakes. Med Hypotheses 2008;70:170 18
24. Modun D, Music I, Katalinic V, Salamunic I, Boban M. Comparison of protective effect of catechin applied in vitro and in vivo on ischemia-reperfusion injury in the isolated rat hearts. Croat Med J 2003;44: 690-696
25. Moon SK, ChoGO, Jung SY, Gal SW, Kwon TK, Lee YC, Madamanchi NR, Kim CH. Quercetin exerts multiple inhibitory effects on vascular smooth muscle cells: role of ERK,1/2 cell- cycle regulation and matrix metalloproteinase-9. Biochem Biophys Res Commun 2003; 301: 1069-1078
26. Nandave M, Ojha SK, Arya DS. Protective role of flavonoids in cardiovascular diseases. Natural Product Radiance 2005; 4: 166-176
27. Pataki T, Bak I,Kovacs P, Bagchi D, Das DK, Tosaki A. Grape seed proanthocyanidins improved cardiac recovery during reperfusion after ischemia in isolated rats hearts. Am J Clin Nutr 2002;75: 894-899
28. Phatharajaree W, Phrommintikul A,Chattipakorn N, Matrix metalloproteinases and myocardial infarction. Can J Cardiol 2007; 23: 727-733
29. Pollard SE, Kuhnle GG, Vauzour D, Vafeiadou K, Tzounis X, Whiteman M, Rice -Evans C, Spencer JP. The reaction of flavonoid metabolites with peroxynitrite. Biochem Biophys Res Commun. 2006 ; 350: 960-968.
30. Potenza MA, Marasciulo FL, Tarquinio M, Tiravanti E, Colantuono G, Federici A, Kim J, Quon MJ, Montagnani M. EGCG, a green tea polyphenol, improves endothelial function and insulin sensitivity reduces blood pressure and protects against myocardial I/R injury in SHR. Am J Physiol Endocrinol Metab 2007; 292: 1378-1387
31. Quin F, Simeone M, Patel R. Inhibition of NADPH oxidase reduces myocardial oxidative stress and apoptosis and improves cardiac function in hearth failure after myocardial infarction. Free Radic Biol Med 2007;43 : 271-281
32. Sierevogel MJ,Pastercampg,de Kleiijn DP, Strauss BH. Matrix metalloproteinases: a therapeutic target in cardiovascular disease. Curr Pharm Des 2003; 9 :10331040
33. Sivaramakrishnan V, Devaraj SN. Morin regulates the expression of NF-Kb-p65,COX-2 and matrix metalloproteinases in diethylnitrosamine induced rat hepatocellular carcinoma. Chem Biol İnteract 2009 ; 180: 353-359
34. Van Hoorn DE, Nijveldt RJ, Van Leuwen PA, Hofman Z, M’ Rrabet L, Debonnd DB, Van Norren K. Numico. Accurate prediction of xanthine oxidase inhibition based on the structure of flavonoids. Eur J Pharmacol 2002; 451 : 111-118
35. Yamazaki KG, Romero-Perez D, Barraza Hidalgo M, Cruz M, Cortez Gomez B,Rivas M, Ceballos G, Villarreal F. Short and long term effect of (-)-epicatechin on myocardial ischemia reperfusion injury. Am J Physiol Heart Circ Physiol 2008 ; 295: 761-767