THE MEASUREMENT OF THE CHOROIDAL THICKNESS DURING ORAL GLUCOSE TOLERANCE TESTS IN PREDIABETIC SUBJECTS: A SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY STUDY

Abstract

Objective: The aim of this study is to investigate how acute hyperglycaemic changes affect the choroid in patients with prediabetes. Material and Method: Each subject underwent a 75 g oral glucose tolerance test (OGTT) after overnight fasting. The measurement of choroidal thickness (ChT) was done with new generation spectral domain optical coherence tomography (SD-OCT). Results: Fasting Plasma Glucose (FPG) levels of the patients with only isolated Impaired Fasting Glucose (IGT) patients are higher (all p<0.0001). Mean insulin levels were also higher in patients with prediabetes than in healthy volunteers during the entire experiment (all p<0.0001). Changes in ChT differed between the groups, a transient increase was observed in the mean ChT as well as subfoveal, nasal and temporal locations at the 500 µm distance to fovea in prediabetes individuals. While the subfoveal ChT difference was 1.52±4.11 µm (range, -11.00/24.00 µm) in prediabetes, -0.22±1.74 µm (range -2.00/8.00 µm) in the control group at the first hour of the OGTT. A transient choroidal thickening occurred in the prediabetes group, while there was Conclusion: Detecting acute hyperglycemic changes with instant measurements may help us to better understand the effect of the disease on ocular structures.

Keywords

• Choroidal thickness
• oral glucose tolerance test
• spectral domain optical coherence tomography

PREDİYABETİK HASTALARDA YAPILAN ORAL GLİKOZ TOLERANS TESTİ ESNASINDA KOROİD KALINLIĞININ ÖLÇÜLMESİ: SPEKTRAL DOMAİN OPTİK KOHERENS TOMOGRAFİ ÇALIŞMASI

Abstract

Amaç: Akut hiperglisemik değişikliklerin prediyabetli hastalarda koroidi nasıl etkilediğini araştırmak. Gereç ve Yöntem: Hastalara en az 8 saat kalori alınmaması sonrası 75 g oral glukoz tolerans testi (OGTT) uygulandı. Koroid kalınlığı (ChT), yeni nesil spektral domain optik koherens tomografi (SD-OCT) ile ölçüldü. Bulgular: Koroid kalınlığındaki değişiklikler gruplar arasında farklılık göstermiştir. Prediyabetli bireylerde, foveaya 500 µm mesafedeki subfoveal, nazal ve temporal lokasyonların yanı sıra ortalama ChT’de geçici bir artış gözlenmiştir. OGTT’nin ilk saatinde; prediyabetik grupta subfoveal koroid kalınlığı farkı 1,52±4,11 µm (aralık, -11,00/24,00 µm) iken, kontrol grubunda subfoveal ChT farkı -0,22±1,74 µm (aralık -2,00/8,00 µm) olarak ölçüldü. Sonuç: Akut hiperglisemik değişikliklerin anlık ölçümlerle saptanması, hastalığın oküler yapılar üzerindeki etkisini daha iyi anlamamıza yardımcı olabilir.

Keywords

• Koroid kalınlığı
• oral glukoz tolerans testi
• spektral domain optik koherens tomografi

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