DIAGNOSTIC VALUE OF SOLUBLE TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS IN SPONTANEOUS BACTERIAL PERITONITIS

Abstract

Objective: The aim of this study is to investigate the role of sTREM-1 molecule in the diagnosis of spontaneous bacterial peritonitis in patients with portal type ascites. Material and Method: We included 122 patients with portal type ascites in the study, 58 had infected ascites (peritonitis) (F/M:27/31, mean age 61.6±15.0 years) and 64 had uninfected ascites (F/M:23/41, mean age 63.4±9.4). Complete blood count, albumin, and C-reactive protein (CRP) were defined in the blood samples. Additionally, neutrophil count, albumin, total protein, lactate dehydrogenase (LDH), and sTREM-1 levels were measured in the peritoneal fluid samples. Results: There were significant differences in ascites neutrophil, serum neutrophil, CRP, ascites LDH, and ascites sTREM-1 levels between two groups. AUC values for ascites neutrophil, serum neutrophil, CRP, and sTREM-1 were 1.0 (95% CI 1.0-1.0), 0.676 (95% CI 0.580-0.771), 0.721 (95% CI 0.632-0.811), and 0.644 (95% CI 0.546-0.74), respectively. In females, sTREM-1 levels were positively correlated with ascites neutrophil, ascites LDH, ascites albumin, ascites total protein levels, and platelet count. Conclusion: Infection of ascites is an important complication of portal hypertension and ascites neutrophil count measurement is the traditional method used for diagnosis. sTREM-1 can be an alternative marker to identify ascites infections, especially in the cases of peritonitis without an increase in neutrophil count.

Keywords

• sTREM-1
• spontaneous bacterial peritonitis
• ascites

SPONTAN BAKTERİYEL PERİTONİTİN TANISINDA STREM-1 MOLEKÜLÜNÜN TANISAL DEĞERİ

Abstract

Amaç: Bu çalışmanın amacı portal tipte asidi olan hastalarda sTREM-1 molekülünün spontan bakteriyel peritonit tanısındaki rolünü araştırmaktır. Gereç ve Yöntem: Çalışmaya portal tipte asiti olan 122 hasta dahil edildi, 58 hastada enfekte asit (K/E:27/31, ortalama yaş 61,6±15,0 yıl), 64 hastada enfekte olmayan asit (K/A:23/41, ortalama yaş 63,4±9,4) vardı. Hastalardan başvuru sırasında alınan kan örneklerinde tam kan sayımı, albümin ve C-reaktif protein (CRP) değerleri; eşzamanlı alınan periton sıvısı örneklerinde ise albümin, total protein, laktat dehidrojenaz, (LDH) ve sTREM-1 seviyeleri ölçüldü. Bulgular: Enfekte asitli ve enfekte olmayan asitli hastalar karşılaştırıldığında asit nötrofil, serum nötrofil, CRP, asit LDH ve asit sTREM-1 düzeylerinde anlamlı farklılıklar görüldü. Asit nötrofil, serum nötrofil, CRP ve sTREM-1 için eğrinin altında kalan alanlar (EAA) sırasıyla 1,0 (%95 CI 1,0-1,0), 0,676 (%95 CI 0,580-0,771), 0,721 (%95 CI 0,632-0,811) ve 0,644 (%95 CI 0,546-0,74) idi. Ayrıca kadın hastalarda sTREM-1 değerleri; asit nötrofil, asit LDH, asit albümin, asit total protein değerleri ve trombosit sayısı ile pozitif korelasyon gösterdi. Sonuç: Asit enfeksiyonu portal hipertansiyonun önemli bir komplikasyonudur ve geleneksel tanı metodu asit nötrofil sayısı ölçümüdür. sTREM-1, özellikle nötrofil sayısında artış olmayan peritonit vakalarında, asit enfeksiyonlarını tanımlamak için alternatif bir belirteç olabilir.

Keywords

• sTREM-1
• spontan bakteriyel peritonit
• asit

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