SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS-2 ANTIGENS AND ANTIBODIES IN BREAST MILK

Abstract

Objective: This study aimed to determine the presence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) antigens and IgM and IgG antibodies in breast milk of mothers diagnosed with Coronavirus disease-19 (COVID-19). Methods: The study was conducted in 11 mother-child pairs. Breastfeeding mothers who were either positive according to a PCR test or those who were negative but had COVID symptoms were included in the study. Expressed milk was stored at -20/-80°C until analysis. Breastmilk SARS-CoV-2 antigens and IgM and IgG antibodies were measured. The infants were followed for at least 15 days. Results: SARS-CoV-2 PCR tests using a nasopharyngeal swab was positive in 10 of 11 mothers. Nine mothers had symptoms of COVID-19. Breast milk samples were taken, on average, 15 days after symptom onset or a positive PCR result. SARS-CoV-2 PCR tests using a nasopharyngeal swab was positive in seven infants. The SARS-CoV-2 antigen was not detected in the breast milk of any of the mothers. However, SARS-CoV-2 IgG and IgM antibodies were detected in the breast milk of two mothers, who had a positive PCR test and experienced clinical symptoms. The children of these two mothers experienced no symptoms. Conclusion: Official institutions have recommended and supported breastfeeding during the SARS-CoV-2 pandemic. Our findings support this recommendation. The promotion and protection of breastfeeding under emergency conditions is of great importance for the health of children, mothers, and society.

Keywords

• Breast milk
• COVID-19
• breastfeeding

ANNE SÜTÜNDE SARS-COV-2 ANTİJENİ VE ANTİKORU

Abstract

Amaç: Koronavirüs hastalığı-19 (COVID-19) tanısı almış annelerin anne sütünde Şiddetli Akut Solunum Sendromu koronavirüs-2 (SARS-CoV-2) antijeni ile IgM ve IgG antikorlarının belirlenmesi amaçlanmıştır. Gereç ve Yöntem: Çalışma 11 anne-çocuk çifti ile gerçekleştirildi. Çalışmaya PCR testine göre pozitif olan veya negatif olup ancak COVID semptomları olan emziren anneler dahil edildi. Sağılmış anne sütü, analiz aşamasına kadar -20/-80°C’de saklandı. Anne sütü SARS-CoV-2 antijeni ve IgM ve IgG antikorları ölçüldü. Bebekler en az 15 gün takip edildi. Bulgular: Nazofarengeal sürüntüde SARS-CoV-2 PCR testleri 11 annenin 10’unda pozitifti. Dokuz annede COVID-19 semptomları vardı. Annelerin semptomlarından veya pozitif PCR sonuçlarından ortalama 15 gün sonra anne sütü örneği alındı. Nazofarengeal sürüntü testlerinde SARS-CoV-2 PCR testleri 11 anne bebeğinin 7’sinde pozitifti. SARS-CoV-2 antijeni hiçbir annenin anne sütünde saptanmadı. Ancak PCR testi pozitif olan ve klinik semptomlar yaşayan iki annenin sütünde SARS-CoV-2 IgG ve IgM antikorları tespit edildi. Bu iki annenin çocukları hiçbir belirti göstermedi. Sonuç: SARS-CoV-2 salgınında resmi kurumlar tarafından emzirme tavsiye edilmiş ve desteklenmiştir. Bulgularımız bu öneriyi desteklemektedir. Emzirmenin acil koşullarda teşviki ve korunması, çocuğun, annenin ve toplumun sağlığı açısından çok önemlidir.

Keywords

• Anne sütü
• COVID-19
• emzirme

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