COVID-19’DA İMMÜN YANITLAR

Abstract

Şiddetli akut solunum sendromu ilişkili bir coronavirüsün (Severe acute respiratory syndrome-related coronavirus 2; SARS-CoV-2) etiyolojik etkeni olduğu coronavirüs hastalığı 19 (coronavirus disease 19; COVID-19) pandemisi mevcut ve olası sonuçları açısından tüm dünyayı etkisi altına almıştır. COVID-19 oldukça özgün virolojik, klinik ve immünolojik karakteristik özelliklere sahiptir. COVID19’da bağışık yanıtlar enfeksiyonunun kontrol altına alınmasına imkan sağlayan yanıtlardan ani ve hızlı gelişen yoğun enflamasyon ve sitokin fırtınası ile karakterize pulmoner trombozise kadar uzunan geniş bir yelpazede değişkenlik gösterebilmektedir. Bu derlemede COVID-19’un immünpatogenizine ilişkin bilimsel verilerin irdelenmesi amaçlanmıştır.

Keywords

• COVID-19
• SARS-CoV-2
• immünpatoloji
• immün regülasyon kaybı
• makrofaj aktivasyonu
• interlökin-6
• sitokin/ kemokin fırtınası
• sitokin/ kemokin fırtınası

IMMUN RESPONSES IN COVID-19

Abstract

The Coronavirus disease 19 (COVID-19) pandemic, which is the etiological agent of a severe acute respiratory syndrome- associated coronavirus (SARS-CoV-2), has influenced the whole world with the current and possible results. COVID-19 has very unique virological, clinical and immunological characteristics. In COVID19, immune responses can vary widely, ranging from responses that allow control of the infection to pulmonary thrombosis characterized by sudden and rapidly developing intense inflammation and storm of cytokenemia. This review aims to examine scientific data about immunopathogenesis of COVID-19

Keywords

• COVID-19
• SARS-CoV-2
• immunopathology
• immune dysregulation
• immune dysregulation
• macrophage activation
• interleukin-6
• cytokine/ chemokine storm
• interleukin-6, cytokine/ chemokine storm

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