COMPARISON OF OVERALL SURVIVAL AND DISEASE-FREE SURVIVAL IN SEROUS ENDOMETRIAL CANCER AND UTERINE CARCINOSARCOMA

Year 2019, Volume: 82 Issue: 1, 1 - 4, 28.03.2019

Alpaslan Kaban Samet Topuz Hamdullah Sozen Yavuz Salihoglu

Abstract

Objective: The aim of this study was to compare the survival durations of patients with uterine carcinosarcoma with the survival of patients with serous endometrial cancer.

Method: Patients who were operated for endometrial cancer between 2002 and 2014 were screened from clinic archive. Patients with histological tumor type carcinosarcoma or serous type were included in the study.

Results: Total number of patients was 99; 53 of them had carcinosarcoma and 46 had serous histology. Median disease-free survival was 20 (2-27) months in carcinosarcoma and 36 (3-180) months in serous type (Log-Rank test p=0.156). Median overall survival duration was 28 (4-170) months for carcinosarcoma and 46 (3-180) months for serous (p=0.105). The 5-year overall survival rate was 41.2% in carcinosarcoma histology and 55.4% in serous histology. After recurrence, patients with carcinosarcoma histology survived for an average of 8 (1-19) months, while those with serous histology survived for an average of 14 (2-43) months (p=0.090).

Conclusion: According to the results of Log-Rank test analysis, no statistically significant survival difference between the patients with uterin carcinosarcoma and with serous endometrial cancer was found. However, disease-free survival, overall survival, and survival duration after recurrence are longer in serous histology than in carcinosarcoma.

Keywords

Endometrium cancer, survival, carcinoma, carcinosarcoma

SERÖZ ENDOMETRİAL KANSER VE UTERİN KARSİNOSARKOMDA GENEL SAĞKALIM VE HASTALIKSIZ SAĞKALIMIN KARŞILAŞTIRILMASI

Abstract

Amaç: Bu çalışmanın amacı uterin karsinosarkomlu hastaların yaşam süresini, seröz endometrial kanserli hastaların yaşam süreleri ile karşılaştırmaktı.

Yöntem: 2002-2014 yılları arasında endometriyal kanser nedeniyle opere edilen hastalar klinik arşivinden tarandı. Çalışmaya histolojik tümör tipi karsinosarkom veya seröz tip olan hastalar dahil edildi.

Bulgular: Toplam hasta sayısı 99; bunların 53’ünde karsinosarkom, 46’sında seröz histoloji saptandı. Medyan hastalıksız sağkalım süresi karsinosarkomda 20 (2-27) ay ve seröz tipte 36 (3-180) aydı (Log-Rank testi p=0,156). Medyan sağkalım süresi karsinosarkom için 28 (4-170) ay, seröz için 46 (3-180) aydı (p=0,105). Beş yıllık genel sağkalım oranı, karsinosarkom histolojisinde %41,2 iken, seröz histolojide %55,4 idi. Nüksten sonra, karsinosarkom histolojisi olan hastalar ortalama 8 (1-19) ay, seröz histolojisi olanlar ortalama 14 (2-43 ay) yaşamışlardı (p=0,090).

Sonuç: Log-Rank test analizi sonuçlarına göre, uterin karsinosarkomlu ve seröz endometriyal kanserli hastalar arasında istatistiksel olarak anlamlı bir sağkalım farkı bulunmadı. Bununla birlikte, hastalıksız sağkalım, genel sağkalım ve nüks sonrası sağkalım süresi seröz histolojide karsinosarkomdan daha uzundur.

Keywords

Endometrium kanseri, sağkalım, karsinom, karsinosarkom

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