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THE RELATIONSHIP BETWEEN SERUM URIC ACID LEVEL AND SEVERITY OF STABLE CORONARY ARTERY DISEASE

Year 2019, Volume: 82 Issue: 1, 18 - 23, 28.03.2019

Abstract

Objective: Cardiovascular disease risk factors are known to be associated with elevated serum uric acid levels. The aim of our study was to evaluate the relationship between the severity of coronary artery disease and serum uric acid levels in patients undergoing coronary angiography for known stable ischemic heart disease.
Material and Method: A total of 76 patients who had stable angina and underwent coronary angiography with objective ischemia were consecutively included in the study. Blood samples were collected from all patients prior to angiography for routine biochemical analysis. Gensini scores were calculated by independent observers. In the statistical analysis of the data, IBM SPSS statistical version 21 package program was used. Statistical significance level was taken as 0.05 in all tests.
Results: The mean age of the patients was 62.2±8.93 years and the male gender was 86% of the study group. The mean serum uric acid level was 6.58±1.76 mg/dl, the mean Gensini score was 73.8±28.7. When the correlation of inflammatory parameters such as serum neutrophil, lymphocyte, hs-CRP and uric acid levels with Gensini score was examined, only serum uric acid level was statistically correlated with Gensini score (r:0.44, p<0.001).
Conclusion: Serum uric acid levels may be a successful predictor of the widespread and severity of stable ischemic heart disease.

References

  • 1. Pan H, Yan D, Xu M, Li F, Ren M, Zhang J, Wu M.Interaction Between Lactate and Uric Acid is Associated With a Higher Prevalence of Metabolic Syndrome: A Community-Based Study. Exp Clin Endocrinol Diabetes. 2018 Sep 10.
  • 2. Xia X, He F, Wu X, Peng F, Huang F, Yu X. Relationship between serum uric acid and all-cause and cardiovascular mortality in patients treated with peritoneal dialysis. Am J Kidney Dis 2014;64(2):257-64.
  • 3. Gertler MM, Garn SM, Levine SA. Serum uric acid in relation to age and physique in health and in coronary heart disease. Ann Intern Med 1951;34:1421-31.
  • 4. Diaz MN, Frei B, Vita JA, Keaney JF. Antioxidants and atherosclerosis heart disease. N Engl J Med1997;337(6):408-16.
  • 5. Saito Y, Kitahara H, Nakayama T, Fujimoto Y, Kobayashi Y. Relation of Elevated Serum Uric Acid Level to Endothelial Dysfunction in Patients with Acute Coronary Syndrome. J Atheroscler Thromb. 2018 Sep 13.
  • 6. Kim SY, Guevara JP, Kim KM, Choi HK, Heitjan DF, Albert DA. Hyperuricemia and coronary heart disease: a systematic review and meta-analysis. Arthritis Care Res 2010;62(2):170-80.
  • 7. Gensini GG. A more meaningful scoring system for determining the severity of coronary heart disease. Am J Cardiol 1983;51(3):606.
  • 8. Roberto ML, Luigi PB, Victor M, Jonathan A, Anderson A, Laura E, et al. Recommendations for Cardiac Chamber Quantification by Echocardiography in Adults: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging 2016;17(4):412.
  • 9. Duran M, Kalay N, Akpek M, Orscelik O, Elcik D, Ocak A. High Levels of Serum Uric Acid predict severity of ischemic heart disease in Patients With Acute Coronary Syndrome. Angiology 2012;63(6):448-52.
  • 10. Qureshi AE, Hameed S, Noeman A. Relationship of serum uric acid level and angiographic severity of coronary artery disease in male patients with acute coronary syndrome. Pak J Med Sci 2013;29(5):1137-41.
  • 11. Xiong Z, Zhu C, Qian X, Zhu J, Wu Z, Chen L. Predictors of clinical SYNTAX score in coronary artery disease: serum uric acid, smoking, and Framingham risk strati cation. J Invasive Cardiol 2011;23(12):501-4.
  • 12. Lu P, Hu D, Lu J, Wang W, Chen B. The association between uric acid and coronary heart disease. Zhonghua Nei Ke Za Zhi 2002;41(8):526-9.
  • 13. Puig JG, Martínez MA. Hyperuricemia, gout and the metabolic syndrome. Curr Opin Rheumatol 2008;20:187-91.
  • 14. Freedman DS, Williamson DF, Gunter EW, Byers T. Relation of serum uric acid to mortality and ischemic heart disease. The NHANES I Epidemiologic Follow-up Study. Am J Epidemiol 1995;141(7):637-44.
  • 15. Ndrepepa G, Braun S, King L, Fusaro M, Tada T, Cassese S. Uric acid and prognosis in angiography-proven coronary artery disease. Eur J Clin Invest 2013;43(3):256-66.
  • 16. Kojima S, Sakamoto T, Ishihara M, Kimura K, Miyazaki S, Yamagishi M. Prognostic usefulness of serum uric acid after acute myocardial infarction (the Japanese Acute Coronary Syndrome Study). Am J Cardiol 2005;96(4):489-95.
  • 17. Tamariz L, Agarwal S, Soliman EZ, Chamberlain AM, Prineas R, Folsom AR. Association of serum uric acid with incident atrial brillation (from the Atherosclerosis Risk in Communities [ARIC] study). Am J Cardiol 2011;108(9):1272-6.
  • 18. Kwon CH, Lee SH, Lee JY, Ryu S, Sung KC. Uric Acid and Risk of Atrial Fibrillation in the Korean General Population. Circ J 2018 25;82(11):2728-35.
  • 19. Noman A, Ang DS, Ogston S. Effect of high-dose allopurinol on exercise in patients with chronic stable angina: a randomised, placebo controlled crossover trial. Lancet 2010;375:2161-7.

SERUM ÜRİK ASİT DÜZEYİNİN KARARLI KORONER ARTER HASTALIĞININ CİDDİYETİ İLE İLİŞKİSİ

Year 2019, Volume: 82 Issue: 1, 18 - 23, 28.03.2019

Abstract

Amaç: İleri yaş, diyabet, hipertansiyon, insulin direnci, hipertrigliseridemi ve metobolik sendrom gibi kardiyovasküler hastalık risk faktörlerinin yüksek serum ürik asit düzeyleri ile ilişkili olduğu bilinmektedir. Çalışmamızın amacı bilinen kararlı iskemik kalp hastalığı nedeniyle koroner anjiyografi yapılan hastalarda serum ürik asit düzeyleri ile koroner arter hastalığının yaygınlığını karşılaştırmaktır.
Gereç ve Yöntem: Kararlı anginası bulunan ve objektif iskemisi gösterilerek koroner anjiyografisi yapılan 76 hasta yazılı ve sözlü onamları alınarak çalışmaya dahil edildi. Tüm hastalardan rutin biyokimyasal tetkik için anjiyografi öncesi kan alındı. Bağımsız gözlemciler tarafından Gensini skorları hesaplandı. Verilerin istatistiksel analizinde IBM SPSS istatistik versiyon 21 paket programı kullanıldı. Tüm testlerde istatistiksel önem düzeyi 0,05 olarak alındı.
Bulgular: Hastaların yaş ortalaması 62,2±8,93, erkek cinsiyet oranı %86 idi. Serum ürik asit düzeyi ortalaması 6,58±1,76 mg/dl, Gensini skoru ortalaması ise 73,8±28,7 idi. Serum nötrofil, lenfosit, hs-CRP ve ürik asit düzeyleri gibi inflamatuvar parametreler ile Gensini skorunun korelasyonuna bakıldığında ise sadece serum ürik asit düzeyi Gensini skoru ile istatistiksel anlamlı korelasyon göstermekteydi (r:0,44, p<0,001).

References

  • 1. Pan H, Yan D, Xu M, Li F, Ren M, Zhang J, Wu M.Interaction Between Lactate and Uric Acid is Associated With a Higher Prevalence of Metabolic Syndrome: A Community-Based Study. Exp Clin Endocrinol Diabetes. 2018 Sep 10.
  • 2. Xia X, He F, Wu X, Peng F, Huang F, Yu X. Relationship between serum uric acid and all-cause and cardiovascular mortality in patients treated with peritoneal dialysis. Am J Kidney Dis 2014;64(2):257-64.
  • 3. Gertler MM, Garn SM, Levine SA. Serum uric acid in relation to age and physique in health and in coronary heart disease. Ann Intern Med 1951;34:1421-31.
  • 4. Diaz MN, Frei B, Vita JA, Keaney JF. Antioxidants and atherosclerosis heart disease. N Engl J Med1997;337(6):408-16.
  • 5. Saito Y, Kitahara H, Nakayama T, Fujimoto Y, Kobayashi Y. Relation of Elevated Serum Uric Acid Level to Endothelial Dysfunction in Patients with Acute Coronary Syndrome. J Atheroscler Thromb. 2018 Sep 13.
  • 6. Kim SY, Guevara JP, Kim KM, Choi HK, Heitjan DF, Albert DA. Hyperuricemia and coronary heart disease: a systematic review and meta-analysis. Arthritis Care Res 2010;62(2):170-80.
  • 7. Gensini GG. A more meaningful scoring system for determining the severity of coronary heart disease. Am J Cardiol 1983;51(3):606.
  • 8. Roberto ML, Luigi PB, Victor M, Jonathan A, Anderson A, Laura E, et al. Recommendations for Cardiac Chamber Quantification by Echocardiography in Adults: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging 2016;17(4):412.
  • 9. Duran M, Kalay N, Akpek M, Orscelik O, Elcik D, Ocak A. High Levels of Serum Uric Acid predict severity of ischemic heart disease in Patients With Acute Coronary Syndrome. Angiology 2012;63(6):448-52.
  • 10. Qureshi AE, Hameed S, Noeman A. Relationship of serum uric acid level and angiographic severity of coronary artery disease in male patients with acute coronary syndrome. Pak J Med Sci 2013;29(5):1137-41.
  • 11. Xiong Z, Zhu C, Qian X, Zhu J, Wu Z, Chen L. Predictors of clinical SYNTAX score in coronary artery disease: serum uric acid, smoking, and Framingham risk strati cation. J Invasive Cardiol 2011;23(12):501-4.
  • 12. Lu P, Hu D, Lu J, Wang W, Chen B. The association between uric acid and coronary heart disease. Zhonghua Nei Ke Za Zhi 2002;41(8):526-9.
  • 13. Puig JG, Martínez MA. Hyperuricemia, gout and the metabolic syndrome. Curr Opin Rheumatol 2008;20:187-91.
  • 14. Freedman DS, Williamson DF, Gunter EW, Byers T. Relation of serum uric acid to mortality and ischemic heart disease. The NHANES I Epidemiologic Follow-up Study. Am J Epidemiol 1995;141(7):637-44.
  • 15. Ndrepepa G, Braun S, King L, Fusaro M, Tada T, Cassese S. Uric acid and prognosis in angiography-proven coronary artery disease. Eur J Clin Invest 2013;43(3):256-66.
  • 16. Kojima S, Sakamoto T, Ishihara M, Kimura K, Miyazaki S, Yamagishi M. Prognostic usefulness of serum uric acid after acute myocardial infarction (the Japanese Acute Coronary Syndrome Study). Am J Cardiol 2005;96(4):489-95.
  • 17. Tamariz L, Agarwal S, Soliman EZ, Chamberlain AM, Prineas R, Folsom AR. Association of serum uric acid with incident atrial brillation (from the Atherosclerosis Risk in Communities [ARIC] study). Am J Cardiol 2011;108(9):1272-6.
  • 18. Kwon CH, Lee SH, Lee JY, Ryu S, Sung KC. Uric Acid and Risk of Atrial Fibrillation in the Korean General Population. Circ J 2018 25;82(11):2728-35.
  • 19. Noman A, Ang DS, Ogston S. Effect of high-dose allopurinol on exercise in patients with chronic stable angina: a randomised, placebo controlled crossover trial. Lancet 2010;375:2161-7.
There are 19 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section RESEARCH
Authors

Samim Emet 0000-0002-2806-4335

Publication Date March 28, 2019
Submission Date January 5, 2019
Published in Issue Year 2019 Volume: 82 Issue: 1

Cite

APA Emet, S. (2019). SERUM ÜRİK ASİT DÜZEYİNİN KARARLI KORONER ARTER HASTALIĞININ CİDDİYETİ İLE İLİŞKİSİ. Journal of Istanbul Faculty of Medicine, 82(1), 18-23.
AMA Emet S. SERUM ÜRİK ASİT DÜZEYİNİN KARARLI KORONER ARTER HASTALIĞININ CİDDİYETİ İLE İLİŞKİSİ. İst Tıp Fak Derg. March 2019;82(1):18-23.
Chicago Emet, Samim. “SERUM ÜRİK ASİT DÜZEYİNİN KARARLI KORONER ARTER HASTALIĞININ CİDDİYETİ İLE İLİŞKİSİ”. Journal of Istanbul Faculty of Medicine 82, no. 1 (March 2019): 18-23.
EndNote Emet S (March 1, 2019) SERUM ÜRİK ASİT DÜZEYİNİN KARARLI KORONER ARTER HASTALIĞININ CİDDİYETİ İLE İLİŞKİSİ. Journal of Istanbul Faculty of Medicine 82 1 18–23.
IEEE S. Emet, “SERUM ÜRİK ASİT DÜZEYİNİN KARARLI KORONER ARTER HASTALIĞININ CİDDİYETİ İLE İLİŞKİSİ”, İst Tıp Fak Derg, vol. 82, no. 1, pp. 18–23, 2019.
ISNAD Emet, Samim. “SERUM ÜRİK ASİT DÜZEYİNİN KARARLI KORONER ARTER HASTALIĞININ CİDDİYETİ İLE İLİŞKİSİ”. Journal of Istanbul Faculty of Medicine 82/1 (March 2019), 18-23.
JAMA Emet S. SERUM ÜRİK ASİT DÜZEYİNİN KARARLI KORONER ARTER HASTALIĞININ CİDDİYETİ İLE İLİŞKİSİ. İst Tıp Fak Derg. 2019;82:18–23.
MLA Emet, Samim. “SERUM ÜRİK ASİT DÜZEYİNİN KARARLI KORONER ARTER HASTALIĞININ CİDDİYETİ İLE İLİŞKİSİ”. Journal of Istanbul Faculty of Medicine, vol. 82, no. 1, 2019, pp. 18-23.
Vancouver Emet S. SERUM ÜRİK ASİT DÜZEYİNİN KARARLI KORONER ARTER HASTALIĞININ CİDDİYETİ İLE İLİŞKİSİ. İst Tıp Fak Derg. 2019;82(1):18-23.

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