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SPONTAN BAKTERİYEL PERİTONİTİN TANISINDA STREM-1 MOLEKÜLÜNÜN TANISAL DEĞERİ

Year 2020, Volume: 83 Issue: 4, 390 - 396, 19.10.2020

Abstract

Amaç: Bu çalışmanın amacı portal tipte asidi olan hastalarda sTREM-1 molekülünün spontan bakteriyel peritonit tanısındaki rolünü araştırmaktır. Gereç ve Yöntem: Çalışmaya portal tipte asiti olan 122 hasta dahil edildi, 58 hastada enfekte asit (K/E:27/31, ortalama yaş 61,6±15,0 yıl), 64 hastada enfekte olmayan asit (K/A:23/41, ortalama yaş 63,4±9,4) vardı. Hastalardan başvuru sırasında alınan kan örneklerinde tam kan sayımı, albümin ve C-reaktif protein (CRP) değerleri; eşzamanlı alınan periton sıvısı örneklerinde ise albümin, total protein, laktat dehidrojenaz, (LDH) ve sTREM-1 seviyeleri ölçüldü. Bulgular: Enfekte asitli ve enfekte olmayan asitli hastalar karşılaştırıldığında asit nötrofil, serum nötrofil, CRP, asit LDH ve asit sTREM-1 düzeylerinde anlamlı farklılıklar görüldü. Asit nötrofil, serum nötrofil, CRP ve sTREM-1 için eğrinin altında kalan alanlar (EAA) sırasıyla 1,0 (%95 CI 1,0-1,0), 0,676 (%95 CI 0,580-0,771), 0,721 (%95 CI 0,632-0,811) ve 0,644 (%95 CI 0,546-0,74) idi. Ayrıca kadın hastalarda sTREM-1 değerleri; asit nötrofil, asit LDH, asit albümin, asit total protein değerleri ve trombosit sayısı ile pozitif korelasyon gösterdi. Sonuç: Asit enfeksiyonu portal hipertansiyonun önemli bir komplikasyonudur ve geleneksel tanı metodu asit nötrofil sayısı ölçümüdür. sTREM-1, özellikle nötrofil sayısında artış olmayan peritonit vakalarında, asit enfeksiyonlarını tanımlamak için alternatif bir belirteç olabilir.

Supporting Institution

İstanbul Üniversitesi Bilimsel Araştırma Projeleri Fonu (BAP)

Project Number

46543

References

  • 1. Rimola A, Garcia-Tsao G, Navasa M, Piddock LJ, Planas R, Bernard B, et al. Diagnosis, treatment and prophylaxis of spontaneous bacterial peritonitis: a consensus document. International Ascites Club. J Hepatol 2000;32(1):142-53.
  • 2. Rostkowska KA, Szymanek-Pasternak A, Simon KA. Spontaneous bacterial peritonitis - therapeutic challenges in the era of increasing drug resistance of bacteria. Clin Exp Hepatol 2018;4(4):224-31.
  • 3. Garcia-Tsao G. Current management of the complications of cirrhosis and portal hypertension: variceal hemorrhage, ascites, and spontaneous bacterial peritonitis. Gastroenterology 2001;120(3):726-48.
  • 4. European Association for the Study of the Liver. EASL Clinical Practice Guidelines on the management of ascites, spontaneous bacterial peritonitis, and hepatorenal syndrome in cirrhosis. J Hepatol 2010;53(3):397-417.
  • 5. Nousbaum JB, Cadranel JF, Nahon P, Khac EN, Moreau R, Thévenot T, et al. Diagnostic accuracy of the Multistix 8 SG reagent strip in diagnosis of spontaneous bacterial peritonitis. Hepatology 2007;45(5):1275-81.
  • 6. Evans LT, Kim WR, Poterucha JJ, Kamath PS. Spontaneous bacterial peritonitis in asymptomatic outpatients with cirrhotic ascites. Hepatology 2003;37(4):897-901.
  • 7. Barati M, Bashar FR, Shahrami R, Zadeh MH, Taher MT, Nojomi M. Soluble triggering receptor expressed on myeloid cells 1 and the diagnosis of sepsis. J Crit Care 2010;25(2):362.e1-6.
  • 8. Bouchon A, Dietrich J, Colonna M. Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J Immunol 2000;164(10):4991-5.
  • 9. Gibot S, Cravoisy A, Levy B, Bene MC, Faure G, Bollaert PE. Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia. N Engl J Med 2004;350(5):451- 8.
  • 10. Sun XG, Ma Q, Jing G, Wang GQ, Hao XD, Wang L. Increased levels of soluble triggering receptor expressed on myeloid cells-1 in cerebrospinal fluid of subarachnoid hemorrhage patients. J Clin Neurosci 2017;35:139-43.
  • 11. Ford JW, McVicar DW. TREM and TREM-like receptors in inflammation and disease. Curr Opin Immunol 2009;21(1):38-46.
  • 12. Pandupuspitasari NS, Khan FA, Huang CJ, Chen X, Zhang S. Novel Attributions of TREMs in Immunity. Curr Issues Mol Biol 2016;20:47-54.
  • 13. Determann RM, van Till JW, van Ruler O, van Veen SQ, Schultz MJ, Boermeester MA. sTREM-1 is a potential useful biomarker for exclusion of ongoing infection in patients with secondary peritonitis. Cytokine 2009;46(1):36-42.
  • 14. Bayram H, Tunger O, Civi M, Yuceyar MH, Ulman C, Dinc H, et al. Diagnostic and prognostic value of procalcitonin and sTREM-1 levels in sepsis. Turk J Med Sci 2015;45/3):578-86.
  • 15. Brenner T, Uhle F, Fleming T, Wieland M, Schmoch T, Schmitt F, et al. Soluble TREM-1 as a diagnostic and prognostic biomarker in patients with septic shock: an observational clinical study. Biomarkers 2017;22(1):63-9.
  • 16. Bouchon A, Facchetti F, Weigand MA, Colonna M. TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature 2001;410(6832):1103-7.
  • 17. Bassyouni IH, Fawzi S, Gheita TA, Bassyouni RH, Nasr AS, El Bakry SA, et al. Clinical association of a soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in patients with systemic lupus erythematosus. Immunol Invest 2017;46(1):38-47.
  • 18. Chubb SP, Williams RA. Biochemical Analysis of Pleural Fluid and Ascites. Clinical Biochemist Reviews 2018;39(2):39-50.
  • 19. Velkey B, Vitális E, Vitális Z. Spontán bakteriális peritonitis [Spontaneous bacterial peritonitis]. Orvosi Hetilap 2017;158(2):50-7.
  • 20. Latour-Perez J, Alcala-Lopez A, Garcia-Garcia MA, Sánchez-Hernández JF, et al. Diagnostic accuracy of sTREM-1 to identify infection in critically ill patients with systemic inflammatory response syndrome. Clin Biochem 2010;43(9):720-4.
  • 21. Charles PE, Noel R, Massin F, Guy J, Bollaert PE, Quenot JP, et al. Significance of soluble triggering receptor expressed on myeloid cells-1 elevation in patients admitted to the intensive care unit with sepsis. BMC Infect Dis 2016;16(1):559.
  • 22. Al-Ghamdi H, Al-Harbi N, Mokhtar H, Daffallah M, Memon Y, Aljumah AA, et al. Changes in the patterns and microbiology of spontaneous bacterial peritonitis: analysis of 200 cirrhotic patients. Acta Gastroenterol Belg 2019;82(2):261-6.
  • 23. Bal CK, Bhatia V, Daman R. Predictors of fifty days in-hospital mortality in patients with culture negative neutrocytic ascites. BMC Gastroenterol 2017;17(1):64.
  • 24. Sajjad M, Khan ZA, Khan MS. Ascitic Fluid Culture in Cirrhotic Patients with Spontaneous Bacterial Peritonitis. J Coll Physicians Surg Pak 2016;26(8):658-61.
  • 25. Gong YX, Cui SN, Li L, Wang MM, Guo N. [Diagnostic value of human neutrophil peptide in spontaneous bacterial peritonitis]. Zhonghua Gan Zang Bing Za Zhi 2013;21(12):944-8.
  • 26. Determann RM, Achouiti AA, El Solh AA, Bresser P, Vijfhuizen J, Spronk PE, et al. Infectious pleural effusions can be identified by sTREM-1 levels. Respir Med 2010;104(2):310e5.

DIAGNOSTIC VALUE OF SOLUBLE TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS IN SPONTANEOUS BACTERIAL PERITONITIS

Year 2020, Volume: 83 Issue: 4, 390 - 396, 19.10.2020

Abstract

Objective: The aim of this study is to investigate the role of sTREM-1 molecule in the diagnosis of spontaneous bacterial peritonitis in patients with portal type ascites. Material and Method: We included 122 patients with portal type ascites in the study, 58 had infected ascites (peritonitis) (F/M:27/31, mean age 61.6±15.0 years) and 64 had uninfected ascites (F/M:23/41, mean age 63.4±9.4). Complete blood count, albumin, and C-reactive protein (CRP) were defined in the blood samples. Additionally, neutrophil count, albumin, total protein, lactate dehydrogenase (LDH), and sTREM-1 levels were measured in the peritoneal fluid samples. Results: There were significant differences in ascites neutrophil, serum neutrophil, CRP, ascites LDH, and ascites sTREM-1 levels between two groups. AUC values for ascites neutrophil, serum neutrophil, CRP, and sTREM-1 were 1.0 (95% CI 1.0-1.0), 0.676 (95% CI 0.580-0.771), 0.721 (95% CI 0.632-0.811), and 0.644 (95% CI 0.546-0.74), respectively. In females, sTREM-1 levels were positively correlated with ascites neutrophil, ascites LDH, ascites albumin, ascites total protein levels, and platelet count. Conclusion: Infection of ascites is an important complication of portal hypertension and ascites neutrophil count measurement is the traditional method used for diagnosis. sTREM-1 can be an alternative marker to identify ascites infections, especially in the cases of peritonitis without an increase in neutrophil count.

Project Number

46543

References

  • 1. Rimola A, Garcia-Tsao G, Navasa M, Piddock LJ, Planas R, Bernard B, et al. Diagnosis, treatment and prophylaxis of spontaneous bacterial peritonitis: a consensus document. International Ascites Club. J Hepatol 2000;32(1):142-53.
  • 2. Rostkowska KA, Szymanek-Pasternak A, Simon KA. Spontaneous bacterial peritonitis - therapeutic challenges in the era of increasing drug resistance of bacteria. Clin Exp Hepatol 2018;4(4):224-31.
  • 3. Garcia-Tsao G. Current management of the complications of cirrhosis and portal hypertension: variceal hemorrhage, ascites, and spontaneous bacterial peritonitis. Gastroenterology 2001;120(3):726-48.
  • 4. European Association for the Study of the Liver. EASL Clinical Practice Guidelines on the management of ascites, spontaneous bacterial peritonitis, and hepatorenal syndrome in cirrhosis. J Hepatol 2010;53(3):397-417.
  • 5. Nousbaum JB, Cadranel JF, Nahon P, Khac EN, Moreau R, Thévenot T, et al. Diagnostic accuracy of the Multistix 8 SG reagent strip in diagnosis of spontaneous bacterial peritonitis. Hepatology 2007;45(5):1275-81.
  • 6. Evans LT, Kim WR, Poterucha JJ, Kamath PS. Spontaneous bacterial peritonitis in asymptomatic outpatients with cirrhotic ascites. Hepatology 2003;37(4):897-901.
  • 7. Barati M, Bashar FR, Shahrami R, Zadeh MH, Taher MT, Nojomi M. Soluble triggering receptor expressed on myeloid cells 1 and the diagnosis of sepsis. J Crit Care 2010;25(2):362.e1-6.
  • 8. Bouchon A, Dietrich J, Colonna M. Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J Immunol 2000;164(10):4991-5.
  • 9. Gibot S, Cravoisy A, Levy B, Bene MC, Faure G, Bollaert PE. Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia. N Engl J Med 2004;350(5):451- 8.
  • 10. Sun XG, Ma Q, Jing G, Wang GQ, Hao XD, Wang L. Increased levels of soluble triggering receptor expressed on myeloid cells-1 in cerebrospinal fluid of subarachnoid hemorrhage patients. J Clin Neurosci 2017;35:139-43.
  • 11. Ford JW, McVicar DW. TREM and TREM-like receptors in inflammation and disease. Curr Opin Immunol 2009;21(1):38-46.
  • 12. Pandupuspitasari NS, Khan FA, Huang CJ, Chen X, Zhang S. Novel Attributions of TREMs in Immunity. Curr Issues Mol Biol 2016;20:47-54.
  • 13. Determann RM, van Till JW, van Ruler O, van Veen SQ, Schultz MJ, Boermeester MA. sTREM-1 is a potential useful biomarker for exclusion of ongoing infection in patients with secondary peritonitis. Cytokine 2009;46(1):36-42.
  • 14. Bayram H, Tunger O, Civi M, Yuceyar MH, Ulman C, Dinc H, et al. Diagnostic and prognostic value of procalcitonin and sTREM-1 levels in sepsis. Turk J Med Sci 2015;45/3):578-86.
  • 15. Brenner T, Uhle F, Fleming T, Wieland M, Schmoch T, Schmitt F, et al. Soluble TREM-1 as a diagnostic and prognostic biomarker in patients with septic shock: an observational clinical study. Biomarkers 2017;22(1):63-9.
  • 16. Bouchon A, Facchetti F, Weigand MA, Colonna M. TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature 2001;410(6832):1103-7.
  • 17. Bassyouni IH, Fawzi S, Gheita TA, Bassyouni RH, Nasr AS, El Bakry SA, et al. Clinical association of a soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in patients with systemic lupus erythematosus. Immunol Invest 2017;46(1):38-47.
  • 18. Chubb SP, Williams RA. Biochemical Analysis of Pleural Fluid and Ascites. Clinical Biochemist Reviews 2018;39(2):39-50.
  • 19. Velkey B, Vitális E, Vitális Z. Spontán bakteriális peritonitis [Spontaneous bacterial peritonitis]. Orvosi Hetilap 2017;158(2):50-7.
  • 20. Latour-Perez J, Alcala-Lopez A, Garcia-Garcia MA, Sánchez-Hernández JF, et al. Diagnostic accuracy of sTREM-1 to identify infection in critically ill patients with systemic inflammatory response syndrome. Clin Biochem 2010;43(9):720-4.
  • 21. Charles PE, Noel R, Massin F, Guy J, Bollaert PE, Quenot JP, et al. Significance of soluble triggering receptor expressed on myeloid cells-1 elevation in patients admitted to the intensive care unit with sepsis. BMC Infect Dis 2016;16(1):559.
  • 22. Al-Ghamdi H, Al-Harbi N, Mokhtar H, Daffallah M, Memon Y, Aljumah AA, et al. Changes in the patterns and microbiology of spontaneous bacterial peritonitis: analysis of 200 cirrhotic patients. Acta Gastroenterol Belg 2019;82(2):261-6.
  • 23. Bal CK, Bhatia V, Daman R. Predictors of fifty days in-hospital mortality in patients with culture negative neutrocytic ascites. BMC Gastroenterol 2017;17(1):64.
  • 24. Sajjad M, Khan ZA, Khan MS. Ascitic Fluid Culture in Cirrhotic Patients with Spontaneous Bacterial Peritonitis. J Coll Physicians Surg Pak 2016;26(8):658-61.
  • 25. Gong YX, Cui SN, Li L, Wang MM, Guo N. [Diagnostic value of human neutrophil peptide in spontaneous bacterial peritonitis]. Zhonghua Gan Zang Bing Za Zhi 2013;21(12):944-8.
  • 26. Determann RM, Achouiti AA, El Solh AA, Bresser P, Vijfhuizen J, Spronk PE, et al. Infectious pleural effusions can be identified by sTREM-1 levels. Respir Med 2010;104(2):310e5.
There are 26 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section RESEARCH
Authors

Alpay Medetalibeyoğlu This is me 0000-0002-5829-9186

Seda Çelik This is me 0000-0003-2055-3537

Rabia Deniz This is me 0000-0003-4537-894X

Emine Bilge Çaparili This is me 0000-0001-9747-244X

Murat Köse This is me 0000-0002-7487-9287

Timur Selçuk Akpınar This is me 0000-0002-9591-4475

Yücel Arman This is me 0000-0002-9584-6644

Adem Atıcı This is me 0000-0001-6580-7954

Murat Akarsu This is me 0000-0002-2675-4252

Şengül Aydın Yoldemir This is me 0000-0003-4236-1181

İbrahim Hakkı Köker This is me 0000-0002-4513-6927

Tufan Tükek This is me 0000-0002-4237-1163

Project Number 46543
Publication Date October 19, 2020
Submission Date April 25, 2020
Published in Issue Year 2020 Volume: 83 Issue: 4

Cite

APA Medetalibeyoğlu, A., Çelik, S., Deniz, R., Çaparili, E. B., et al. (2020). DIAGNOSTIC VALUE OF SOLUBLE TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS IN SPONTANEOUS BACTERIAL PERITONITIS. Journal of Istanbul Faculty of Medicine, 83(4), 390-396.
AMA Medetalibeyoğlu A, Çelik S, Deniz R, Çaparili EB, Köse M, Akpınar TS, Arman Y, Atıcı A, Akarsu M, Aydın Yoldemir Ş, Köker İH, Tükek T. DIAGNOSTIC VALUE OF SOLUBLE TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS IN SPONTANEOUS BACTERIAL PERITONITIS. İst Tıp Fak Derg. October 2020;83(4):390-396.
Chicago Medetalibeyoğlu, Alpay, Seda Çelik, Rabia Deniz, Emine Bilge Çaparili, Murat Köse, Timur Selçuk Akpınar, Yücel Arman, Adem Atıcı, Murat Akarsu, Şengül Aydın Yoldemir, İbrahim Hakkı Köker, and Tufan Tükek. “DIAGNOSTIC VALUE OF SOLUBLE TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS IN SPONTANEOUS BACTERIAL PERITONITIS”. Journal of Istanbul Faculty of Medicine 83, no. 4 (October 2020): 390-96.
EndNote Medetalibeyoğlu A, Çelik S, Deniz R, Çaparili EB, Köse M, Akpınar TS, Arman Y, Atıcı A, Akarsu M, Aydın Yoldemir Ş, Köker İH, Tükek T (October 1, 2020) DIAGNOSTIC VALUE OF SOLUBLE TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS IN SPONTANEOUS BACTERIAL PERITONITIS. Journal of Istanbul Faculty of Medicine 83 4 390–396.
IEEE A. Medetalibeyoğlu, “DIAGNOSTIC VALUE OF SOLUBLE TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS IN SPONTANEOUS BACTERIAL PERITONITIS”, İst Tıp Fak Derg, vol. 83, no. 4, pp. 390–396, 2020.
ISNAD Medetalibeyoğlu, Alpay et al. “DIAGNOSTIC VALUE OF SOLUBLE TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS IN SPONTANEOUS BACTERIAL PERITONITIS”. Journal of Istanbul Faculty of Medicine 83/4 (October 2020), 390-396.
JAMA Medetalibeyoğlu A, Çelik S, Deniz R, Çaparili EB, Köse M, Akpınar TS, Arman Y, Atıcı A, Akarsu M, Aydın Yoldemir Ş, Köker İH, Tükek T. DIAGNOSTIC VALUE OF SOLUBLE TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS IN SPONTANEOUS BACTERIAL PERITONITIS. İst Tıp Fak Derg. 2020;83:390–396.
MLA Medetalibeyoğlu, Alpay et al. “DIAGNOSTIC VALUE OF SOLUBLE TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS IN SPONTANEOUS BACTERIAL PERITONITIS”. Journal of Istanbul Faculty of Medicine, vol. 83, no. 4, 2020, pp. 390-6.
Vancouver Medetalibeyoğlu A, Çelik S, Deniz R, Çaparili EB, Köse M, Akpınar TS, Arman Y, Atıcı A, Akarsu M, Aydın Yoldemir Ş, Köker İH, Tükek T. DIAGNOSTIC VALUE OF SOLUBLE TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS IN SPONTANEOUS BACTERIAL PERITONITIS. İst Tıp Fak Derg. 2020;83(4):390-6.

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