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DISSEMINE INTRAVASCULAR COAGULATION MAY BE THE PRESENTING FEATURE FOR CHRONIC MYELOMONOCYTIC LEUKEMIA

Year 2020, Volume: 83 Issue: 4, 307 - 308, 19.10.2020

Abstract

Chronic myelomonocytic leukemia (CMML) is a malignant myeloid stem cell disease accompanied by dysplasia in the context of myeloproliferative disease. Peripheral cytopenias (mainly anemia and thrombocytopenia) and hepatosplenomegaly are common findings. Dramatic leukocytosis can also be seen without transformation to acute myeloid leukemia (AML). In some cases, this is associated with leukostasis and end organ damage. Splenomegaly is present in up to 25% of patients and is often accompanied by hepatomegaly, lymphadenopathy, or nodular cutaneous leukemic infiltrates. The acquired cogulation defect may be due to factor X binding to atypical monocytes, resulting in acquired factor X deficiency. We would like to highlight the challenging diagnosis and treatment of CMML.

References

  • 1. Bernat AL, Priola SM, Elsawy A, et al. Chronic subdural collection overlying an intra-axial hemorrhagic lesion in chronic myelomonocytic leukemia: special report and review of the literature. Expert Rev Neurother 2018;18(5):371-7.
  • 2. Arber DA, Orazi A, Hasserjian R, et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood 2016;127(20):2391- 405.
  • 3. Altieri DC, Edgington TS. The saturable high affinity association of factor X to ADP-stimulated monocytes defines a novel function of the Mac-1 receptor. J Biol Chem 1988;263(15):7007-15.
  • 4. Edwards RL, Rickles FR, Bobrove AM. Mononuclear cell tissue factor: cell of origin and requirements for activation. Blood 1979;54(2):359-70. [CrossRef]
  • 5. Gregory SA, Kornbluth RS, Helin H, et al. Monocyte procoagulant inducing factor: a lymphokine involved in the T cell-instructed monocyte procoagulant response to antigen. J Immunol 1986;137(10):3231-9.
  • 6. Edwards RL, Rickles FR, Cronlund M. Abnormalities of blood coagulation in patients with cancer. Mononuclear cell tissue factor generation. J Lab Clin Med 1981;98(6):917-28.
  • 7. Kantarjian H, Issa JP, Rosenfeld CS, et al. Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study. Cancer 2006;106(8):1794-803.
  • 8. Kantarjian H, Oki Y, Garcia-Manero G, et al. Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia. Blood 2007;109(1):52-7.
  • 9. Kantarjian HM, O’Brien S, Shan J, et al. Update of the decitabine experience in higher risk myelodysplastic syndrome and analysis of prognostic factors associated with outcome. Cancer 2007;109(2):265-73.
  • 10. Santini V, Allione B, Zini G, et al. A phase II, multicentre trial of decitabine in higher-risk chronic myelomonocytic leukemia. Leukemia 2018;32(2):413-8. [

YAYGIN DAMAR İÇİ PIHTILAŞMA İLE GELEN KRONİK MYELOMONOSİTİK LÖSEMİ

Year 2020, Volume: 83 Issue: 4, 307 - 308, 19.10.2020

Abstract

References

  • 1. Bernat AL, Priola SM, Elsawy A, et al. Chronic subdural collection overlying an intra-axial hemorrhagic lesion in chronic myelomonocytic leukemia: special report and review of the literature. Expert Rev Neurother 2018;18(5):371-7.
  • 2. Arber DA, Orazi A, Hasserjian R, et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood 2016;127(20):2391- 405.
  • 3. Altieri DC, Edgington TS. The saturable high affinity association of factor X to ADP-stimulated monocytes defines a novel function of the Mac-1 receptor. J Biol Chem 1988;263(15):7007-15.
  • 4. Edwards RL, Rickles FR, Bobrove AM. Mononuclear cell tissue factor: cell of origin and requirements for activation. Blood 1979;54(2):359-70. [CrossRef]
  • 5. Gregory SA, Kornbluth RS, Helin H, et al. Monocyte procoagulant inducing factor: a lymphokine involved in the T cell-instructed monocyte procoagulant response to antigen. J Immunol 1986;137(10):3231-9.
  • 6. Edwards RL, Rickles FR, Cronlund M. Abnormalities of blood coagulation in patients with cancer. Mononuclear cell tissue factor generation. J Lab Clin Med 1981;98(6):917-28.
  • 7. Kantarjian H, Issa JP, Rosenfeld CS, et al. Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study. Cancer 2006;106(8):1794-803.
  • 8. Kantarjian H, Oki Y, Garcia-Manero G, et al. Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia. Blood 2007;109(1):52-7.
  • 9. Kantarjian HM, O’Brien S, Shan J, et al. Update of the decitabine experience in higher risk myelodysplastic syndrome and analysis of prognostic factors associated with outcome. Cancer 2007;109(2):265-73.
  • 10. Santini V, Allione B, Zini G, et al. A phase II, multicentre trial of decitabine in higher-risk chronic myelomonocytic leukemia. Leukemia 2018;32(2):413-8. [
There are 10 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Letter
Authors

Itır Şirinoğlu Demiriz This is me 0000-0001-7931-7104

A. Gülsan Türköz Sucak This is me 0000-0002-7707-0029

Publication Date October 19, 2020
Submission Date July 24, 2019
Published in Issue Year 2020 Volume: 83 Issue: 4

Cite

APA Şirinoğlu Demiriz, I., & Türköz Sucak, A. G. (2020). DISSEMINE INTRAVASCULAR COAGULATION MAY BE THE PRESENTING FEATURE FOR CHRONIC MYELOMONOCYTIC LEUKEMIA. Journal of Istanbul Faculty of Medicine, 83(4), 307-308.
AMA Şirinoğlu Demiriz I, Türköz Sucak AG. DISSEMINE INTRAVASCULAR COAGULATION MAY BE THE PRESENTING FEATURE FOR CHRONIC MYELOMONOCYTIC LEUKEMIA. İst Tıp Fak Derg. October 2020;83(4):307-308.
Chicago Şirinoğlu Demiriz, Itır, and A. Gülsan Türköz Sucak. “DISSEMINE INTRAVASCULAR COAGULATION MAY BE THE PRESENTING FEATURE FOR CHRONIC MYELOMONOCYTIC LEUKEMIA”. Journal of Istanbul Faculty of Medicine 83, no. 4 (October 2020): 307-8.
EndNote Şirinoğlu Demiriz I, Türköz Sucak AG (October 1, 2020) DISSEMINE INTRAVASCULAR COAGULATION MAY BE THE PRESENTING FEATURE FOR CHRONIC MYELOMONOCYTIC LEUKEMIA. Journal of Istanbul Faculty of Medicine 83 4 307–308.
IEEE I. Şirinoğlu Demiriz and A. G. Türköz Sucak, “DISSEMINE INTRAVASCULAR COAGULATION MAY BE THE PRESENTING FEATURE FOR CHRONIC MYELOMONOCYTIC LEUKEMIA”, İst Tıp Fak Derg, vol. 83, no. 4, pp. 307–308, 2020.
ISNAD Şirinoğlu Demiriz, Itır - Türköz Sucak, A. Gülsan. “DISSEMINE INTRAVASCULAR COAGULATION MAY BE THE PRESENTING FEATURE FOR CHRONIC MYELOMONOCYTIC LEUKEMIA”. Journal of Istanbul Faculty of Medicine 83/4 (October 2020), 307-308.
JAMA Şirinoğlu Demiriz I, Türköz Sucak AG. DISSEMINE INTRAVASCULAR COAGULATION MAY BE THE PRESENTING FEATURE FOR CHRONIC MYELOMONOCYTIC LEUKEMIA. İst Tıp Fak Derg. 2020;83:307–308.
MLA Şirinoğlu Demiriz, Itır and A. Gülsan Türköz Sucak. “DISSEMINE INTRAVASCULAR COAGULATION MAY BE THE PRESENTING FEATURE FOR CHRONIC MYELOMONOCYTIC LEUKEMIA”. Journal of Istanbul Faculty of Medicine, vol. 83, no. 4, 2020, pp. 307-8.
Vancouver Şirinoğlu Demiriz I, Türköz Sucak AG. DISSEMINE INTRAVASCULAR COAGULATION MAY BE THE PRESENTING FEATURE FOR CHRONIC MYELOMONOCYTIC LEUKEMIA. İst Tıp Fak Derg. 2020;83(4):307-8.

Contact information and address

Addressi: İ.Ü. İstanbul Tıp Fakültesi Dekanlığı, Turgut Özal Cad. 34093 Çapa, Fatih, İstanbul, TÜRKİYE

Email: itfdergisi@istanbul.edu.tr

Phone: +90 212 414 21 61