INCIDENCE OF HYDATIDIFORM MOLE IN SYRIAN IMMIGRANT WOMEN AND TURKISH WOMEN

Year 2020, Volume: 83 Issue: 4, 427 - 433, 19.10.2020

Taşkın Erkinüresin , Hakan Demirci

Abstract

Objective: Immigration may affect the incidence of hydatidiform mole (HM). In this study, we aim to compare Syrian immigrant and Turkish pregnant women in terms of HM due to abortion and termination of pregnancy. Method: An analysis of 907 endometrial curettage materials due to abortion or termination of pregnancy between the years 2016- 2018 were performed. These curettage materials were examined with routine histopathologic methods. Examination of the curettage materials was repeated by a pathologist to confirm the diagnosis. Results: HM was diagnosed in 56 of 768 Turkish pregnant women (7.30%) and it was diagnosed in 22 of 139 Syrian immigrant pregnant women (15.80%). HM incidence in Syrian immigrant pregnant women was significantly higher (2.06 times) than in Turkish women (p=0.001). The rate of Syrian pregnant women in the group aged 20 or younger was significantly higher than Turkish pregnant women (p<0.001). The rate of Turkish pregnant women aged between 30-34 and older was high in the group. Conclusions: The incidence of HM is higher in Syrian pregnant women. The main causes affecting the incidence of HM in Syrian immigrants are nationality and age. Migration, with all its components, may explain the difference in HM incidence between these two neighboring communities.

Keywords

Adolescent pregnancy, dilatation and curettage, histopathology, hydatidiform mole, Syrian refugee

SURİYELİ GÖÇMEN VE TÜRK KADINLARINDA HİDATİFORM MOL İNSİDANSI

Abstract

Amaç: Göç hidatiform mol (HM) insidansını etkileyebilir. Bu çalışmada, küretaj uygulanan ve gebeliği sonlandırılan Suriyeli göçmen ve Türk gebe kadınların HM açısından karşılaştırılması amaçlanmıştır. Yöntem: 2016-2018 yılları arasında küretaj uygulanan ve gebeliği sonlandırılan 907 endometriyal küretaj materyalinin analizi yapıldı. Bu küretaj materyalleri rutin histopatolojik yöntemlerle incelendi. Küretaj materyallerinin incelenmesi, tanıyı doğrulamak için bir patolog tarafından tekrarlandı. Bulgular: HM, 768 Türk gebe kadından 56’sında (%7.30) ve 139 Suriyeli göçmen gebe kadından 22’sinde (%15,80) teşhis edildi. Suriyeli göçmen gebe kadınlarda HM insidansı Türk gebe kadınlara göre (2,06 kat) anlamlı derecede yüksekti (p=0.001). Yirmi yaşından küçük olan gruptaki Suriyeli gebe kadınların oranı Türk gebe kadınlara göre anlamlı olarak daha yüksekti (p<0.001). Türk gebe kadınların oranı ise 30-34 yaş ve daha yaşlı olan grupta yüksekti. Sonuç: Suriyeli göçmen gebe kadınlarda HM insidansı daha yüksektir. Suriyeli göçmenlerde HM insidansını etkileyen başlıca nedenler milliyet ve yaştır. Göçmenlik tüm bileşenleri ile bu iki komşu topluluk arasındaki HM insidansındaki farkı açıklayabilir.

Keywords

Adolesan gebelik, dilatasyon ve küretaj, hidatiform mol, histopatoloji, Suriyeli göçmen

References

• 1. Mülteciler Derneği. Türkiyedeki Suriyeli Sayısı. Available from: URL: https://multeciler.org.tr/turkiyedeki-suriyelisayisi/ Access Date: 22.05.2019.
• 2. Anadolu Ajansı. Türkiye’de doğan Suriyeli bebek sayısı açıklandı. Available from: https://www.aa.com.tr/tr/turkiye/ turkiyede-dogan-suriyeli-bebek-sayisi-aciklandi/1144564. Access Date: 22.05.2019.
• 3. Seckl MJ, Sebire NJ, Berkowitz RS. Gestational trophoblastic disease. Lancet 2010;376(9742):717-29. [CrossRef]
• 4. Adalı Y, Eroğlu HA, Güvendi GF, Deniz R, Baykuş Y. Frequency of hydatidiform mole in curettage material between 2014 and 2016 in a university hospital. Med Sci 2018;13(3):66-71. [CrossRef]
• 5. Lurain JR. Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole. Am J Obstet Gynecol 2010;203(6):531-9. [CrossRef]
• 6. Curry SL, Hammond CB, Tyrey L, Creasman WT, Parker RT. Hydatidiform mole: diagnosis, management, and long-term follow up of 347 patients. Obstet Gynecol 1975;45(1):1-8. [CrossRef]
• 7. Kohorn EI. Molar pregnancy: presentation and diagnosis. Clin Obstet Gynecol 1984;27:181-9. [CrossRef]
• 8. Soto-Wright V, Bernstein M, Goldstein DP, Berkowitz RS. The changing clinical presentation of complete molar pregnancy. Obstet Gynecol 1995;86(5):775-9. [CrossRef]
• 9. Hou JL, Wan XR, Xiang Y, Qi QW, Yang XY. Changes of clinical features in hydatidiform mole: analysis of 113 cases. J Reprod Med 2008;53(8):629-33.
• 10. Czernobilsky B, Barash A, Lancet M. Partial moles: a clinicopathologic study of 25 cases. Obstet Gynecol 1982;59:75-7.
• 11. Szulman AE, Surti U. The clinicopathologic profile of the partial hydatidiform mole. Obstet Gynecol 1982;59:597- 602.
• 12. Berkowitz RS, Goldstein DP, Bernstein MR. Natural history of partial molar pregnancy. Obstet Gynecol 1985;66:677-81.
• 13. Biscaro A, Silveira SK, Locks GD, Mileo LR, Silva Júnior JP, Pretto P. Frequency of hydatidiform mole in tissue obtained by curettage. Rev Bras de Ginecol Obstet 2012;34(6):254-8.
• 14. Mbamara SU, Obiechina NJ, Eleje GU, Akabuike CJ, Umeononihu OS. Gestational trophoblastic disease in a tertiary hospital in Nnewi, southeast Nigeria. Niger Med J 2009;50(4):87.
• 15. Moodley M, Tunkyi K, Moodley J. Gestational trophoblastic syndrome: an audit of 112 patients. A South African experience. Int J Gynecol Cancer 2003;13(2):234-9. [CrossRef]
• 16. Brinton LA, Bracken MB, Connelly RR. Choriocarcinoma incidence in the United States. Am J Epidemiol 1986;123:1094-100. [CrossRef]
• 17. Smith HO, Qualls CR, Prairie BA, Padilla LA, Rayburn WF, Key CR. Trends in gestational choriocarcinoma: a 27-year perspective. Obstet Gynecol 2003;102(5):978-87. [CrossRef]
• 18. Parazzini F, LaVecchia C, Pampallona S. Parental age and risk of complete and partial Hydatidiform mole. Br J Obstet Gynecol 1986;93:582-5. [CrossRef]
• 19. Sebire NJ, Foskett M, Fisher RA, Rees H, Seckl M, Newlands E. Risk of partial and complete hydatidiform molar pregnancy in relation to maternal age. BJOG 2002;109(1):99-102. [CrossRef]
• 20. Sand PK, Lurain JR, Brewer JI. Repeat gestational trophoblastic disease. Obstet Gynecol 1984;63(2):140-4.
• 21. Berkowitz RS, Im SS, Bernstein MR, Goldstein DP. Gestational trophoblastic disease: Subsequent pregnancy outcome, including repeat molar pregnancy. J Reprod Med 1998; 43:81-6.
• 22. Parazzini F, Mangili GI, La CV, Negri E, Bocciolone L, Fasoli M. Risk factors for gestational trophoblastic disease: a separate analysis of complete and partial hydatidiform moles. Obstet Gynecol 1991;78(6):1039-45.
• 23. Ghaemmaghami F, Ashraf-Ganjooie T. Gestational trophoblastic neoplasia. Asia Pac J Clin Oncol 2006;2(1):9- 21. [CrossRef]
• 24. Berkowitz RS, Cramer DW, Bernstein MR, Cassells S, Driscoll SG, Goldstein DP. Risk factors for complete molar pregnancy from a case-control study. Am J Obstet Gynecol 1985;152(8):1016-20.
• 25. Parazzini F, La Vecchia C, Mangili G, Caminiti C, Negri E, Cecchetti G, Fasoli M. Dietary factors and risk of trophoblastic disease. Am J Obstet Gynecol 1988;158(1):93- 9. [CrossRef]
• 26. Horn LC, Rosenkranz M, Bilek K. The value of placental histology for the detection of genetically-induced abortions. Z Geburtshilfe Perinatol 1991;195(2):47-53.
• 27. Mulisya O, Roberts DJ, Sengupta ES, Agaba E, Laffita D, Tobias T, Mpiima DP, Henry L, Augustine S, Abraham M, Hillary T. Prevalence and Factors Associated with Hydatidiform Mole among Patients Undergoing Uterine Evacuation at Mbarara Regional Referral Hospital. Obstet Gynecol Int 2018;2018:9561413.