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PREEKLAMPSİDE PLAZMA PRO-İNFLAMATUAR VE ANTİ-İNFLAMATUAR SİTOKİN DÜZEYLERİ

Year 2008, Volume: 71 Issue: 1, 9 - 13, 14.11.2011

Abstract

Amaç: Sitokinler normal gebeliğin sürdürülmesi ve patolojik durumların ortaya çıkmasında önemli rol oynar. Bu çalışmada preeklampside plazma sitokin paternini incelemek ve hastalığın seyri ile bir ilişkisi olup olmadığını değerlendirmek hedeflenmiştir. Gereç ve yöntem: 25’i sağlıklı ve gebe olmayan (NP), 20’si normotensif gebe (NTP), ve 20’si preeklamptik gebe (PEP) olmak üzere toplam 65 kadının plazma örneklerinde TNFα, IL-1β, IL-12, IL-4 ve IL-10 konsantrasyonları tayin edildi. İstatistiksel değerlendirme Student’s t-, Kruskal-Wallis, Mann-Whitney U- ve Spearman korelasyon testleri ile gerçekleştirildi. Bulgular: NP kadınlara kıyasla, PEP’de pro-inflamatuar ve Th1 sitokinleri olan TNFα, IL-1β, IL-12 artışı ile birlikte anti-inflamatuar ve Th2 sitokinleri olan IL-4 ve IL-10 de artmaktadır. Bununla birlikte, NTP’ye kıyasla PEP’de anti-inflamatuar IL-4 ve IL-10 düzeyleri artmaktadır. Preeklampsi grubunda IL-1β/ IL-10; TNFα/IL-12 arasında pozitif; IL-4/sistolik kan basıncı ve IL-4/LDH arasında ise negatif korelasyon bulundu. Sonuçlar: Anti-inflamatuar sitokin artışı pro-inflamatuar sitokinlerin neden olduğu endotel disfonksiyonuna karşı koyan bir kompensatuar mekanizma olabilir. Anti-inflamatuar sitokinler ile kan basıncı veya bazı karaciğer enzimleri arasında bulunan negatif korelasyon, plazma sitokin düzeyleri ve hastalığın seyri arasında bir ilişki olabileceğini ortaya koymaktadır. Bununla birlikte, preeklampside anne plazmasında IL-4 ve IL-10 konsantrasyonlarının artışının, Th1/Th2 sitokin dengesini etkileyerek, maternal imünorejeksiyondan korumaya çalışan bir cevap olduğunu söyleyebiliriz.

References

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  • Chen G, Wilson R, Wang SH, Zheng HZ, Walker JJ, McKillop JH. Tumor necrosis factor-alpha (TNFα) gene polymorphism and expression in pre-eclampsia. Clin Exp Immunol 1996; 104: 154-159.
  • Conrad KP, Miles TM, Benyo DF. Circulating levels of immu- noreactive cytokines in women with preeclampsia. Am J Reprod Immunol 1998; 40: 102-111.
  • Dinarello CA. Interleukin-1, interleukin-1 receptors and interle- ukin-1 receptor antagonist. Int Rev Immunol 1998; 16: 457-499.
  • Dong MY, Shi XL, He J, Wang ZP, Xie X, Wang HZ. Imbalan- ce of serum T helper1- and 2-type cytokines in preeclampsia and gestational hypertension. Zhejiang Da Xue Xue Bao Yi Xue Ban 2005; 34: 488-491.
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  • Greig PC, Herbert WNP, Robinette BL, Teot LA. Amniotic flu- id interleukin-10 concentrations increase though pregnancy and are elevated in patients with preterm labor associated with intra- uterine infection. Am J Obstet Gynecol 1995; 173: 1223-1227.
  • Haimovici F, Hill JA, Anderson DJ. The effects of soluble pro- ducts of activated lymphocytes and macrophages on blastocyst implantation events in vitro. Biol Reprod 1991; 4: 69-75.
  • Hefler L, Temper CB, Gregg AR. Polymorphisms within the in- terleukin-1βgene cluster and preeclampsia. Obstet Gynecol 2001; 97: 664-668.
  • Hennessay A, Pulmore HL, Simmons LA, Painter DM. A defici- ency of plasental IL-10 in preeclampsia. J Immunol 1999; 163: 3491-3495.
  • Heyl W, Handt S, Reister F, Gehlen J, Schröder W, Mittermayer C, Rath W et al. Elevated soluble adhesion molecules in women with preeclampsia. Do cytokines like tumor necrosis factor-α and interleukin -1βcause endothelial activation? Eur J Obstet Gynecol 1999; 86: 35-41.
  • Huang SJ, Schatz F, Masch R, Rahman M, Buchwalder L, Ni- ven-Fairchild T, Tang C, Abrahams WM, Krikun G, Lockwood CJ. Regulation of chemokine production in response to pro-inf- lammatory cytokines in first trimester decidual cells. J Reprod Immunol 2006; 72: 60-73.
  • Jonsson Y, Ruber M, Matthiesen L, Berg G, Nieminen K, Shar- ma S, Ernerudh J, Ekerfelt C. Cytokine mapping of sera from women with preeclampsia and normal pregnancies. J Reprod Immunol 2006; 70: 83-91.
  • Kilpatrick DC. HLA-dependent TNF secretory response may provide an immunogenetic link between preeclampsia and type 1 diabetes mellitus. Dis Markers 1996; 13: 43-47.
  • Mosmann TR. Interleukin-10. In: Thomson AW, editor. The cytokine handbook. California: Academic Press 1994; 223-237.
  • Opsjon SL, Austgulen R, Waage A. Interleukin-1, interlukin-6 and tumor necrosis factor at deliery in preeclamptic disorders. Acta Obstet Scand 1995; 74: 19-26.
  • Raghupathy R, Makhseed M, Azizieh F, Hassan N, Al-Aze- mi M, Al-Shamali E. Maternal Th1- and Th2- type reactivity to placental antigens in normal human pregnancy and unexp- lained recurrent spontaneous abortions. Cell Immunol 1999; 196: 122-130.
  • Reinehart BK, Terrone DA, Lagoo-Deenadaylan S, Barber WH, Hale EA, Martin JN, Bennet WA. Expression of placental cyto- kines tumor necrosis factor alfa, interleukin 1 beta, and interle- ukin 10 is increased in preeclampsia. Am J Obstet Gynecol 1999; 181: 915-20.
  • Roberts JM, Redman CWG. Preeclampsia: more than preg- nancy-induced hypertension. Lancet 1993; 341: 1447-1454.
  • Sad S, Mosmann TR. Interleukin (IL) 4, in the absence of anti- gen stimulation, induces an anergy-like state in differentiated CD8+ TC1 cells: loss of IL-2 synthesis and autonomous prolife- ration but but retention of cytotoxicity and synthesisi of other cytokines. J Exper Med 1995; 182: 1505-1515.
  • Seki H, Matuoka K, Inooku H, Takeda S. TNF-alpha from mo- nocyte of patients with pre-eclampsia-induced apoptosis in hu- man trophoblast cell line. J Obstet Gynaecol Res 2007; 33: 408- 416.
  • Vane JR, Anggard EE, Botting RM. Regulatory functions of the vascular endothelium. N Engl J Med 1990; 323: 27-36.
  • Vural P, Akgul C, Canbaz M. Urinary PGE2 and PGF2αlevels and renal functions in preeclampsia. Gynecol Obstet Invest 1998; 45: 237-241.
  • Vural P. Nitric oxide/endothelin-1 in preeclampsia. Clinica Chi- mica Acta 2002; 317: 65-70.
  • Wang Y, Walsh SW, Kay HH. Placental lipid peroxides and thromboxane are increased and prostacyclin is decreased in wo- men with preeclampsia. Am J Obstet Gynecol 1992; 167: 946- 949.
  • Yelevarthi KK, Chen G, Yang Y, Cowlet BD, Fiscback JL, Hunt JS. Tumor necrosis factor-αmRNA and protein in rat uterine and placental cells. J Immunol 1991; 146: 3840-3848.
  • Yui J, Garcia- Lloret M, Wegmann TG, Guilbert LJ. Cytotoxicity of tumor necrosis factor-alpha and gamma-interferon against pri- mary human placental trophoblasts. Placenta 1994, 15: 819-835.
Year 2008, Volume: 71 Issue: 1, 9 - 13, 14.11.2011

Abstract

References

  • Abbas AK, Lichtman AH, Pober JS: Cellular and Molecular Im- munology. 2nd e. Philadelphia, WB Saunders, 1994.
  • Bozychowski AM, Croy BA, Chan WL, Redman CW, Sargent IL. Changes in systemic type 1 and 2 immunity in normal preg- nancy and pree-clampsia may be mediated by natural killer cells. Eur j Immunol 2005; 35: 3054-3063.
  • Chaouat G, Menu E, Clark DA, Dy M, Minkowski M, Weg- mann TG. Control of fetal survival in CBAxDBA/2 mice by lymphokine therapy. J Reprod Fertil 1990; 89: 447-458.
  • Chen G, Wilson R, McKillop JH, Walker JJ. The role of cytoki- nes in the production of prostacyclin and thromboxane in human mononuclear cells. Immunol Invest 1994; 23: 269-279.
  • Chen G, Wilson R, Wang SH, Zheng HZ, Walker JJ, McKillop JH. Tumor necrosis factor-alpha (TNFα) gene polymorphism and expression in pre-eclampsia. Clin Exp Immunol 1996; 104: 154-159.
  • Conrad KP, Miles TM, Benyo DF. Circulating levels of immu- noreactive cytokines in women with preeclampsia. Am J Reprod Immunol 1998; 40: 102-111.
  • Dinarello CA. Interleukin-1, interleukin-1 receptors and interle- ukin-1 receptor antagonist. Int Rev Immunol 1998; 16: 457-499.
  • Dong MY, Shi XL, He J, Wang ZP, Xie X, Wang HZ. Imbalan- ce of serum T helper1- and 2-type cytokines in preeclampsia and gestational hypertension. Zhejiang Da Xue Xue Bao Yi Xue Ban 2005; 34: 488-491.
  • Ellis J, Wennerholm MB, Bengtsson A, Lilja H, Pettersson A, Sultan B, Wennerger M,Hagber H. Levels of dimethylarginines and cytokines in mild and severe preeclampsia. Acta Obstet Gynecol Scand 2001; 80: 602-608.
  • Freeman DJ, McManus F, Brown EA, t al. Short- and long-term changes in plasma inflammatory markers associated with preec- lampsia. Hypertension 2004; 43: 708-714.
  • Greig PC, Herbert WNP, Robinette BL, Teot LA. Amniotic flu- id interleukin-10 concentrations increase though pregnancy and are elevated in patients with preterm labor associated with intra- uterine infection. Am J Obstet Gynecol 1995; 173: 1223-1227.
  • Haimovici F, Hill JA, Anderson DJ. The effects of soluble pro- ducts of activated lymphocytes and macrophages on blastocyst implantation events in vitro. Biol Reprod 1991; 4: 69-75.
  • Hefler L, Temper CB, Gregg AR. Polymorphisms within the in- terleukin-1βgene cluster and preeclampsia. Obstet Gynecol 2001; 97: 664-668.
  • Hennessay A, Pulmore HL, Simmons LA, Painter DM. A defici- ency of plasental IL-10 in preeclampsia. J Immunol 1999; 163: 3491-3495.
  • Heyl W, Handt S, Reister F, Gehlen J, Schröder W, Mittermayer C, Rath W et al. Elevated soluble adhesion molecules in women with preeclampsia. Do cytokines like tumor necrosis factor-α and interleukin -1βcause endothelial activation? Eur J Obstet Gynecol 1999; 86: 35-41.
  • Huang SJ, Schatz F, Masch R, Rahman M, Buchwalder L, Ni- ven-Fairchild T, Tang C, Abrahams WM, Krikun G, Lockwood CJ. Regulation of chemokine production in response to pro-inf- lammatory cytokines in first trimester decidual cells. J Reprod Immunol 2006; 72: 60-73.
  • Jonsson Y, Ruber M, Matthiesen L, Berg G, Nieminen K, Shar- ma S, Ernerudh J, Ekerfelt C. Cytokine mapping of sera from women with preeclampsia and normal pregnancies. J Reprod Immunol 2006; 70: 83-91.
  • Kilpatrick DC. HLA-dependent TNF secretory response may provide an immunogenetic link between preeclampsia and type 1 diabetes mellitus. Dis Markers 1996; 13: 43-47.
  • Mosmann TR. Interleukin-10. In: Thomson AW, editor. The cytokine handbook. California: Academic Press 1994; 223-237.
  • Opsjon SL, Austgulen R, Waage A. Interleukin-1, interlukin-6 and tumor necrosis factor at deliery in preeclamptic disorders. Acta Obstet Scand 1995; 74: 19-26.
  • Raghupathy R, Makhseed M, Azizieh F, Hassan N, Al-Aze- mi M, Al-Shamali E. Maternal Th1- and Th2- type reactivity to placental antigens in normal human pregnancy and unexp- lained recurrent spontaneous abortions. Cell Immunol 1999; 196: 122-130.
  • Reinehart BK, Terrone DA, Lagoo-Deenadaylan S, Barber WH, Hale EA, Martin JN, Bennet WA. Expression of placental cyto- kines tumor necrosis factor alfa, interleukin 1 beta, and interle- ukin 10 is increased in preeclampsia. Am J Obstet Gynecol 1999; 181: 915-20.
  • Roberts JM, Redman CWG. Preeclampsia: more than preg- nancy-induced hypertension. Lancet 1993; 341: 1447-1454.
  • Sad S, Mosmann TR. Interleukin (IL) 4, in the absence of anti- gen stimulation, induces an anergy-like state in differentiated CD8+ TC1 cells: loss of IL-2 synthesis and autonomous prolife- ration but but retention of cytotoxicity and synthesisi of other cytokines. J Exper Med 1995; 182: 1505-1515.
  • Seki H, Matuoka K, Inooku H, Takeda S. TNF-alpha from mo- nocyte of patients with pre-eclampsia-induced apoptosis in hu- man trophoblast cell line. J Obstet Gynaecol Res 2007; 33: 408- 416.
  • Vane JR, Anggard EE, Botting RM. Regulatory functions of the vascular endothelium. N Engl J Med 1990; 323: 27-36.
  • Vural P, Akgul C, Canbaz M. Urinary PGE2 and PGF2αlevels and renal functions in preeclampsia. Gynecol Obstet Invest 1998; 45: 237-241.
  • Vural P. Nitric oxide/endothelin-1 in preeclampsia. Clinica Chi- mica Acta 2002; 317: 65-70.
  • Wang Y, Walsh SW, Kay HH. Placental lipid peroxides and thromboxane are increased and prostacyclin is decreased in wo- men with preeclampsia. Am J Obstet Gynecol 1992; 167: 946- 949.
  • Yelevarthi KK, Chen G, Yang Y, Cowlet BD, Fiscback JL, Hunt JS. Tumor necrosis factor-αmRNA and protein in rat uterine and placental cells. J Immunol 1991; 146: 3840-3848.
  • Yui J, Garcia- Lloret M, Wegmann TG, Guilbert LJ. Cytotoxicity of tumor necrosis factor-alpha and gamma-interferon against pri- mary human placental trophoblasts. Placenta 1994, 15: 819-835.
There are 31 citations in total.

Details

Primary Language Turkish
Journal Section Clinical Research
Authors

Neslihan Yıldırım Saral This is me

Cemil Akgül This is me

Pervin Vural This is me

Publication Date November 14, 2011
Submission Date November 14, 2011
Published in Issue Year 2008 Volume: 71 Issue: 1

Cite

APA Yıldırım Saral, N., Akgül, C., & Vural, P. (2011). PREEKLAMPSİDE PLAZMA PRO-İNFLAMATUAR VE ANTİ-İNFLAMATUAR SİTOKİN DÜZEYLERİ. Journal of Istanbul Faculty of Medicine, 71(1), 9-13.
AMA Yıldırım Saral N, Akgül C, Vural P. PREEKLAMPSİDE PLAZMA PRO-İNFLAMATUAR VE ANTİ-İNFLAMATUAR SİTOKİN DÜZEYLERİ. İst Tıp Fak Derg. November 2011;71(1):9-13.
Chicago Yıldırım Saral, Neslihan, Cemil Akgül, and Pervin Vural. “PREEKLAMPSİDE PLAZMA PRO-İNFLAMATUAR VE ANTİ-İNFLAMATUAR SİTOKİN DÜZEYLERİ”. Journal of Istanbul Faculty of Medicine 71, no. 1 (November 2011): 9-13.
EndNote Yıldırım Saral N, Akgül C, Vural P (November 1, 2011) PREEKLAMPSİDE PLAZMA PRO-İNFLAMATUAR VE ANTİ-İNFLAMATUAR SİTOKİN DÜZEYLERİ. Journal of Istanbul Faculty of Medicine 71 1 9–13.
IEEE N. Yıldırım Saral, C. Akgül, and P. Vural, “PREEKLAMPSİDE PLAZMA PRO-İNFLAMATUAR VE ANTİ-İNFLAMATUAR SİTOKİN DÜZEYLERİ”, İst Tıp Fak Derg, vol. 71, no. 1, pp. 9–13, 2011.
ISNAD Yıldırım Saral, Neslihan et al. “PREEKLAMPSİDE PLAZMA PRO-İNFLAMATUAR VE ANTİ-İNFLAMATUAR SİTOKİN DÜZEYLERİ”. Journal of Istanbul Faculty of Medicine 71/1 (November 2011), 9-13.
JAMA Yıldırım Saral N, Akgül C, Vural P. PREEKLAMPSİDE PLAZMA PRO-İNFLAMATUAR VE ANTİ-İNFLAMATUAR SİTOKİN DÜZEYLERİ. İst Tıp Fak Derg. 2011;71:9–13.
MLA Yıldırım Saral, Neslihan et al. “PREEKLAMPSİDE PLAZMA PRO-İNFLAMATUAR VE ANTİ-İNFLAMATUAR SİTOKİN DÜZEYLERİ”. Journal of Istanbul Faculty of Medicine, vol. 71, no. 1, 2011, pp. 9-13.
Vancouver Yıldırım Saral N, Akgül C, Vural P. PREEKLAMPSİDE PLAZMA PRO-İNFLAMATUAR VE ANTİ-İNFLAMATUAR SİTOKİN DÜZEYLERİ. İst Tıp Fak Derg. 2011;71(1):9-13.

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