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SİSTEMİK LUPUS ERİTEMATOZUS ETYOPATOGENEZİNDE VİRÜSLERİN ROLÜ

Year 2005, Volume: 68 Issue: 3, 85 - 91, 15.11.2011

Bahar Artım-esen Bahar Esen Murat İnanç

Abstract

Sistemik lupus eritematozus (SLE) çok sayıda otoantikor ve farklı klinik tablolarla karakterize, kronik, inflamatuvar otoimmün bir hastalıktır. İnfeksiyon ajanlarından virüslerin SLE patogenezinde çevresel tetikleyici etkenler olabilecekleri öne sürülmüş, konağın immün sistemi ile olan ilişkisi ve şimdiye kadar yapılan klinik ve laboratuvar çalışmalarda elde edilen kanıtlar nedeniyle de Epstein Barr virüs (EBV) bu virüslerin en çok ilgi çekeni olmuştur. EBV infeksiyonunun tüm dünyada yaygın olması, EBV’nin infeksiyondan sonra yaşam boyu konakta varlığını sürdürebilmesi ve bağışıklık sistemini uyaran sürekli bir kaynak oluşturması EBV’nin SLE gelişimi için risk oluşturan özelliklerinden başlıcaları olarak ileri sürülmektedir. Bu yazıda virüslerin otoimmünite gelişimindeki rolleri ve SLE-EBV ilişkisi şimdiye kadar yapılan önemli çalışmalar ışığında özetlenmiştir.

References

  • Artım-Esen B. Sistemik Lupus Eritematozus ve Epstein- Barr virüs infeksiyonunun ilişkisi. Uzmanlık Tezi 2004.
  • Burdin N, Peronne C, Banchereau J, Rousset F. Epstein-Barr virus transformation induces B lymphocytes to produce hu- man interleukin 10. J Exp Med 1993; 177:295-304.
  • Casciola-Rosen LA, Anhalt G, Rosen A. Autoantigens targe- ted in systemic lupus erythematosus are clustered in two po- pulations of surface structures on apoptotic keratinocytes. J Exp Med 1994; 179:1317-1330.
  • Chen CJ, Lin KH, Lin SC, Tsai WC, Yen JH, Chang SJ, Lu SN, Liu HW.High prevalence of IgA antibody against epste- in-barr virus capsid antigen in adult patients with lupus with disease flare: case control studies. J Rheumatol 2005; 32:44- 47.
  • Cohen JI. Epstein-Barr virus infection. N Engl J Med 2000; 343:481-492.
  • Delves PJ, Roitt IM. The immune system. First of two parts. N Engl J Med 2000; 343: 37-49.
  • Delves PJ, Roitt IM. The immune system. Second of two parts. N Engl J Med 2000; 343: 108-117.
  • Elson CJ, Barker RN, Thompson SJ, Williams NA. Immuno- logically ignorant autoreactive T cells, epitope spreading and repertoire limitation. Immunol Today 1995; 16:71-76.
  • Fields BN. Herpesviridae. “ Editörler: Fields BN. Fields Viro- logy, 3.baskı, Lippincott-Raven, 1996 kitabında s. 318-346.
  • Garcia-Porrua C, Gonzalez-Gay MA, Perez de Llano LA, Alvarez-Ferreira J. Fatal interstitial pneumonia due to cyto- megalovirus following cyclophosphamide treatment in a pa- tient with systemic lupus erythematosus. Scand J Rheumatol 1998; 27:465-466.
  • Gül A, İnanç M, Yılmaz G, Öcal L, Koniçe M, Aral O, Ba- dur S, Dilşen N. Antibodies reactive with HIV-1 antigens in systemic lupus erythematosus. Lupus 1996; 5:120-122.
  • Hayashi T, Lee S, Ogasawara H, , Sekigawa I, Iida N, Tomi- no Y, Hashimoto H, Hirose S. Exacerbation of systemic lu- pus erythematosus related to cytomegalovirus infection. Lu- pus 1998; 7:561-564.
  • Herrmann M, Hagenhofer M, Kalden JR. Retroviruses and systemic lupus erythematosus. Immunol Rev 1996; 152:145- 156.
  • Horwitz MS, Sarvetnick N. Viruses, host responses, and au- toimmunity. Immunol Rev 1999; 169:241-253.
  • Huggins ML, Todd I, Powell RJ. Reactivation of Epstein- Barr virus in patients with systemic lupus erythematosus. Rheumatol Int 2005; 25:183-187.
  • Ikura Y, Matsua T, Ogami M, Yamazaki S, Okamura M, Yos- hikawa J, Ueda M. Cytomegalovirus associated pancreatitis in a patient with systemic lupus erythematosus. J Rheumatol 2000; 27:2715-2717.
  • Incaprera M, Rindi L, Bazzichi A, Garzelli C. Potential role of the Epstein-Barr virus in systemic lupus erythematosus autoimmunity. Clin Exp Rheumatol 1998; 16:289-294.
  • İnanç M. Sistemik Lupus Eritematozus. Modern Tıp Semi- nerleri:13-Artritler, Ankara:Güneş Kitabevi, 2001; 21-40.
  • James JA, Harley JB. Linear epitope mapping of an Sm B/B' polypeptide.
  • J Immunol 1992; 148:2074-2079.
  • James JA, Kaufman KM, Farris AD, Taylor-Albert E, Leh- man TA, Harley JB. An increased prevalence of Epstein- Barr virus infection in young patients suggests a possible eti- ology for systemic lupus erythematosus. J Clin Invest 1997; 100:3019-3026.
  • James JA, Neas BN, Moser KL, Hall T, Bruner GR, Sestak AL, Harley JB. Systemic lupus erythematosus in adults is as- sociated with previous Epstein-Barr virus exposure. Arthritis Rheum 2001; 44:1122-1126.
  • Kamradt T, Mitchison NA. Tolerance and autoimmunity. N Engl J Med 2001; 344:655-664.
  • Kang I, Quan T, Nolasco H, Park H, Hong MS, Crouch J, Pa- mer EG, Howe JG, Craft J. Defective control of latent Eps- tein-Barr virus infection in systemic lupus erythematosus. J Immunol 2004; 172:1287-1294.
  • Lau CS, Yuen KY, Chan KH, Wong RW. Lack of evidence of active lytic replication of Epstein-Barr and cytomegaloviru- ses in patients with systemic lupus erythematosus. Chin Med J (Engl) 1998; 111:660-665.
  • Manzi SM, Stark VE, Goldman R. Epidemiology and classi- fication of systemic lupus erythematosus.“Editörler: Hoch- berg MC, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH. Rheumatology, 3.baskı, Edinburgh: Mosby, 2003” ki- tabında s 1294.
  • Moon UY, Park SJ, Oh ST, Kim WU, Park SH, Lee SH, Cho CS, Kim HY, Lee WK, Lee SK. Patients with SLE have ab- normally elevated EBV load in blood. Arthritis Res Ther 2004; 6:295-302.
  • Naucler CS, Larsson S, Moller E. A novel mechanism for vi- rus-induced autoimmunity in humans. Immunol Rev 1996; 152:175-192.
  • Parks CG, Cooper GS, Hudson LL, Dooley MA, Treadwell EL, St.Clair EW, Gilkeson GS, Pandey JP. Association of Epstein-Barr virus with systemic lupus erythematosus. Arth- ritis Rheum 2005; 52:1148-1159.
  • Pender MP. Infection of autoreactive B lymphocytes with EBV, causing chronic autoimmune diseases.Trends Immunol 2003; 24:584-588.
  • Petersen J, Rhodes G, Roudier J, Vaughan JH. Altered im- mune response to glycine-rich sequences of Epstein-Barr nuclear antigen-1 in patients with rheumatoid arthritis and systemic lupus erythematosus. Arthritis Rheum 1990; 33:993-1000.
  • Rider JR, Ollier WER, Lock RJ, Brookes ST, Pamphilon DH. Human cytomegalovirus infection and systemic lupus erythematosus. Clin Exp Rheumatol 1997; 15: 405-409.
  • Rouse BT, Deshpande S. Viruses and autoimmunity: an affa- ir but not a marriage contract. Rev Med Virol 2002; 12:107- 113.
  • Sabbatini A, Bombardieri S, Migliorini P. Autoantibodies from patients with systemic lupus erythematosus bind a sha- red sequence of SmD and Epstein-Barr virus-encoded nucle- ar antigen EBNA I. Eur J Immunol 1993; 23:1146-52.
  • Sculley DG, Sculley TB, Pope JH. Reactions of sera from patients with rheumatoid arthritis, systemic lupus erythema- tosus and infectious mononucleosis to Epstein-Barr virus-in- duced polypeptides. J Gen Virol 1986; 67:2253-2258.
  • Tsai YT, Chiang BL, Kao YF, Hsieh KH. Detection of Eps- tein-Barr virus and cytomegalovirus genome in white blood cells from patients with juvenile rheumatoid arthritis and childhood systemic lupus erythematosus. Int Arch Allergy Immunol 1995; 106:235-240.
  • Yu S, Wu HC, Tsai W, Yen JH, Chiang W, Yuo CY, Lu SN, Chiang CH, Chen CJ. Detecting Epstein-Barr virus DNA from peripheral blood mononuclear cells in adult patients with systemic lupus erythematosus in Taiwan. Med Microbi- ol Immunol (Berl) 2005; 194:115-120.
  • Whitton JL, Fujinami RS. Viruses as triggers of autoimmu- nity: facts and fantasies. Curr Opin Microbiol 1999; 2:392- 397.

Year 2005, Volume: 68 Issue: 3, 85 - 91, 15.11.2011

Bahar Artım-esen Bahar Esen Murat İnanç

Abstract

References

  • Artım-Esen B. Sistemik Lupus Eritematozus ve Epstein- Barr virüs infeksiyonunun ilişkisi. Uzmanlık Tezi 2004.
  • Burdin N, Peronne C, Banchereau J, Rousset F. Epstein-Barr virus transformation induces B lymphocytes to produce hu- man interleukin 10. J Exp Med 1993; 177:295-304.
  • Casciola-Rosen LA, Anhalt G, Rosen A. Autoantigens targe- ted in systemic lupus erythematosus are clustered in two po- pulations of surface structures on apoptotic keratinocytes. J Exp Med 1994; 179:1317-1330.
  • Chen CJ, Lin KH, Lin SC, Tsai WC, Yen JH, Chang SJ, Lu SN, Liu HW.High prevalence of IgA antibody against epste- in-barr virus capsid antigen in adult patients with lupus with disease flare: case control studies. J Rheumatol 2005; 32:44- 47.
  • Cohen JI. Epstein-Barr virus infection. N Engl J Med 2000; 343:481-492.
  • Delves PJ, Roitt IM. The immune system. First of two parts. N Engl J Med 2000; 343: 37-49.
  • Delves PJ, Roitt IM. The immune system. Second of two parts. N Engl J Med 2000; 343: 108-117.
  • Elson CJ, Barker RN, Thompson SJ, Williams NA. Immuno- logically ignorant autoreactive T cells, epitope spreading and repertoire limitation. Immunol Today 1995; 16:71-76.
  • Fields BN. Herpesviridae. “ Editörler: Fields BN. Fields Viro- logy, 3.baskı, Lippincott-Raven, 1996 kitabında s. 318-346.
  • Garcia-Porrua C, Gonzalez-Gay MA, Perez de Llano LA, Alvarez-Ferreira J. Fatal interstitial pneumonia due to cyto- megalovirus following cyclophosphamide treatment in a pa- tient with systemic lupus erythematosus. Scand J Rheumatol 1998; 27:465-466.
  • Gül A, İnanç M, Yılmaz G, Öcal L, Koniçe M, Aral O, Ba- dur S, Dilşen N. Antibodies reactive with HIV-1 antigens in systemic lupus erythematosus. Lupus 1996; 5:120-122.
  • Hayashi T, Lee S, Ogasawara H, , Sekigawa I, Iida N, Tomi- no Y, Hashimoto H, Hirose S. Exacerbation of systemic lu- pus erythematosus related to cytomegalovirus infection. Lu- pus 1998; 7:561-564.
  • Herrmann M, Hagenhofer M, Kalden JR. Retroviruses and systemic lupus erythematosus. Immunol Rev 1996; 152:145- 156.
  • Horwitz MS, Sarvetnick N. Viruses, host responses, and au- toimmunity. Immunol Rev 1999; 169:241-253.
  • Huggins ML, Todd I, Powell RJ. Reactivation of Epstein- Barr virus in patients with systemic lupus erythematosus. Rheumatol Int 2005; 25:183-187.
  • Ikura Y, Matsua T, Ogami M, Yamazaki S, Okamura M, Yos- hikawa J, Ueda M. Cytomegalovirus associated pancreatitis in a patient with systemic lupus erythematosus. J Rheumatol 2000; 27:2715-2717.
  • Incaprera M, Rindi L, Bazzichi A, Garzelli C. Potential role of the Epstein-Barr virus in systemic lupus erythematosus autoimmunity. Clin Exp Rheumatol 1998; 16:289-294.
  • İnanç M. Sistemik Lupus Eritematozus. Modern Tıp Semi- nerleri:13-Artritler, Ankara:Güneş Kitabevi, 2001; 21-40.
  • James JA, Harley JB. Linear epitope mapping of an Sm B/B' polypeptide.
  • J Immunol 1992; 148:2074-2079.
  • James JA, Kaufman KM, Farris AD, Taylor-Albert E, Leh- man TA, Harley JB. An increased prevalence of Epstein- Barr virus infection in young patients suggests a possible eti- ology for systemic lupus erythematosus. J Clin Invest 1997; 100:3019-3026.
  • James JA, Neas BN, Moser KL, Hall T, Bruner GR, Sestak AL, Harley JB. Systemic lupus erythematosus in adults is as- sociated with previous Epstein-Barr virus exposure. Arthritis Rheum 2001; 44:1122-1126.
  • Kamradt T, Mitchison NA. Tolerance and autoimmunity. N Engl J Med 2001; 344:655-664.
  • Kang I, Quan T, Nolasco H, Park H, Hong MS, Crouch J, Pa- mer EG, Howe JG, Craft J. Defective control of latent Eps- tein-Barr virus infection in systemic lupus erythematosus. J Immunol 2004; 172:1287-1294.
  • Lau CS, Yuen KY, Chan KH, Wong RW. Lack of evidence of active lytic replication of Epstein-Barr and cytomegaloviru- ses in patients with systemic lupus erythematosus. Chin Med J (Engl) 1998; 111:660-665.
  • Manzi SM, Stark VE, Goldman R. Epidemiology and classi- fication of systemic lupus erythematosus.“Editörler: Hoch- berg MC, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH. Rheumatology, 3.baskı, Edinburgh: Mosby, 2003” ki- tabında s 1294.
  • Moon UY, Park SJ, Oh ST, Kim WU, Park SH, Lee SH, Cho CS, Kim HY, Lee WK, Lee SK. Patients with SLE have ab- normally elevated EBV load in blood. Arthritis Res Ther 2004; 6:295-302.
  • Naucler CS, Larsson S, Moller E. A novel mechanism for vi- rus-induced autoimmunity in humans. Immunol Rev 1996; 152:175-192.
  • Parks CG, Cooper GS, Hudson LL, Dooley MA, Treadwell EL, St.Clair EW, Gilkeson GS, Pandey JP. Association of Epstein-Barr virus with systemic lupus erythematosus. Arth- ritis Rheum 2005; 52:1148-1159.
  • Pender MP. Infection of autoreactive B lymphocytes with EBV, causing chronic autoimmune diseases.Trends Immunol 2003; 24:584-588.
  • Petersen J, Rhodes G, Roudier J, Vaughan JH. Altered im- mune response to glycine-rich sequences of Epstein-Barr nuclear antigen-1 in patients with rheumatoid arthritis and systemic lupus erythematosus. Arthritis Rheum 1990; 33:993-1000.
  • Rider JR, Ollier WER, Lock RJ, Brookes ST, Pamphilon DH. Human cytomegalovirus infection and systemic lupus erythematosus. Clin Exp Rheumatol 1997; 15: 405-409.
  • Rouse BT, Deshpande S. Viruses and autoimmunity: an affa- ir but not a marriage contract. Rev Med Virol 2002; 12:107- 113.
  • Sabbatini A, Bombardieri S, Migliorini P. Autoantibodies from patients with systemic lupus erythematosus bind a sha- red sequence of SmD and Epstein-Barr virus-encoded nucle- ar antigen EBNA I. Eur J Immunol 1993; 23:1146-52.
  • Sculley DG, Sculley TB, Pope JH. Reactions of sera from patients with rheumatoid arthritis, systemic lupus erythema- tosus and infectious mononucleosis to Epstein-Barr virus-in- duced polypeptides. J Gen Virol 1986; 67:2253-2258.
  • Tsai YT, Chiang BL, Kao YF, Hsieh KH. Detection of Eps- tein-Barr virus and cytomegalovirus genome in white blood cells from patients with juvenile rheumatoid arthritis and childhood systemic lupus erythematosus. Int Arch Allergy Immunol 1995; 106:235-240.
  • Yu S, Wu HC, Tsai W, Yen JH, Chiang W, Yuo CY, Lu SN, Chiang CH, Chen CJ. Detecting Epstein-Barr virus DNA from peripheral blood mononuclear cells in adult patients with systemic lupus erythematosus in Taiwan. Med Microbi- ol Immunol (Berl) 2005; 194:115-120.
  • Whitton JL, Fujinami RS. Viruses as triggers of autoimmu- nity: facts and fantasies. Curr Opin Microbiol 1999; 2:392- 397.
There are 38 citations in total.

Details

Primary Language Turkish
Journal Section Reviews
Authors

Bahar Artım-esen This is me

Bahar Esen This is me

Murat İnanç This is me

Publication Date November 15, 2011
Submission Date November 15, 2011
Published in Issue Year 2005 Volume: 68 Issue: 3

Cite

APA Artım-esen, B., Esen, B., & İnanç, M. (2011). SİSTEMİK LUPUS ERİTEMATOZUS ETYOPATOGENEZİNDE VİRÜSLERİN ROLÜ. Journal of Istanbul Faculty of Medicine, 68(3), 85-91.
AMA Artım-esen B, Esen B, İnanç M. SİSTEMİK LUPUS ERİTEMATOZUS ETYOPATOGENEZİNDE VİRÜSLERİN ROLÜ. İst Tıp Fak Derg. November 2011;68(3):85-91.
Chicago Artım-esen, Bahar, Bahar Esen, and Murat İnanç. “SİSTEMİK LUPUS ERİTEMATOZUS ETYOPATOGENEZİNDE VİRÜSLERİN ROLÜ”. Journal of Istanbul Faculty of Medicine 68, no. 3 (November 2011): 85-91.
EndNote Artım-esen B, Esen B, İnanç M (November 1, 2011) SİSTEMİK LUPUS ERİTEMATOZUS ETYOPATOGENEZİNDE VİRÜSLERİN ROLÜ. Journal of Istanbul Faculty of Medicine 68 3 85–91.
IEEE B. Artım-esen, B. Esen, and M. İnanç, “SİSTEMİK LUPUS ERİTEMATOZUS ETYOPATOGENEZİNDE VİRÜSLERİN ROLÜ”, İst Tıp Fak Derg, vol. 68, no. 3, pp. 85–91, 2011.
ISNAD Artım-esen, Bahar et al. “SİSTEMİK LUPUS ERİTEMATOZUS ETYOPATOGENEZİNDE VİRÜSLERİN ROLÜ”. Journal of Istanbul Faculty of Medicine 68/3 (November 2011), 85-91.
JAMA Artım-esen B, Esen B, İnanç M. SİSTEMİK LUPUS ERİTEMATOZUS ETYOPATOGENEZİNDE VİRÜSLERİN ROLÜ. İst Tıp Fak Derg. 2011;68:85–91.
MLA Artım-esen, Bahar et al. “SİSTEMİK LUPUS ERİTEMATOZUS ETYOPATOGENEZİNDE VİRÜSLERİN ROLÜ”. Journal of Istanbul Faculty of Medicine, vol. 68, no. 3, 2011, pp. 85-91.
Vancouver Artım-esen B, Esen B, İnanç M. SİSTEMİK LUPUS ERİTEMATOZUS ETYOPATOGENEZİNDE VİRÜSLERİN ROLÜ. İst Tıp Fak Derg. 2011;68(3):85-91.

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