TÜYLÜ HÜCRELİ LÖSEMİ TANILI İKİ OLGUDA BİRİNCİ DİZİ VE NÜKSTE KLADRİBİN UYGULAMASI

Year 2011, Volume: 74 Issue: 4, 66 - 71, 08.02.2012

İpek Yönal Raif Coşkun Fehmi Hindilerden Erkan Özcan Öner Doğan Selim Yavuz Meliha Nalçacı

Abstract

Tüylü hücreli lösemi (THL) birinci dizi ve nükste purin nükleozid analoğu olan kladribin (2-klorodeoksiadenozin) ile tedavi edilebilen nadir görülen kronik seyirli lenfoproliferatif hastalıktır. Bu yazıda THL tanısı ile kladribin uygulanarak tam remisyon (TR) elde edilmiş ve tanının 6. yılında nüks nedeniyle tekrar kladribin uygulanması sonrası 3. ayda kemik iliği biyopsisinde retikülin liflerinin kaybolduğu, tüylü lösemi hücrelerinin de saptanmadığı (tekrar TR elde edilen) bir olgu ve THL tanısı ile kladribin uygulanarak TR elde edilen, tanının 14. yılında nüks THL tanısıyla kladribin uygulanmasının 23. gününde nötropenik ateş, candida pnömonisi ve septik şok sonucu eks olan ikinci bir olgu bildirilmektedir.

Keywords

Tüylü hücreli lösemi, nüks tüylü hücreli lösemi, kladribin (2-klorodeoksiadenozin)

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• İstanbul Tıp Fakültesi Dergisi Cilt / Volume: 71 • Sayı / Number: 4 • Yıl/Year: 2011