CUTANEOUS LICHEN PLANUS AS A RARE MANIFESTATION OF CHRONIC HEPATITIS B INFECTION: A CASE REPORT

Year 2025, Volume: 88 Issue: 3, 243 - 246, 31.07.2025

Behich Koyutourk , Melis Kalayci , Ertan Direnc , Kaya Süer

https://doi.org/10.26650/IUITFD.1686176

Abstract

Hepatitis B virus (HBV) infection causes severe liver diseases, in-cluding cirrhosis and hepatocellular carcinoma (HCC), and remains a major global health issue, contributing to liver related morbidity and mortality. Autoimmune conditions like Lichen Planus (LP) can exist in patients because of HBV infection. We present a case of a patient with a history of chronic HBV infection, confirmed by HBV DNA positivity via polymerase chain reaction (PCR), who developed clinical symptoms of LP. The patient had been receiving antiviral treatment for chronic HBV. Clinical evidence supports the potential link between LP and HBV infection, although the exact mechanisms remain unclear. Further research involving larger patient populations is essential to fully understand this relationship and to improve screening and management strategies, especially in endemic regions.

Keywords

Hepatitis B virus , Lichen planus , antiviral agents

KRONİK HEPATİT B ENFEKSİYONUNUN NADİR BİR GÖRÜNÜMÜ OLARAK KUTANÖZ LİKEN PLANUS: BİR OLGU SUNUMU

Abstract

Hepatit B virüsü (HBV) enfeksiyonu, siroz ve hepatosellüler karsinom (HCC) dahil olmak üzere ciddi karaciğer hastalıklarına yol açmakta olup, karaciğer kaynaklı morbidite ve mortaliteye katkıda bulunarak halen önemli bir küresel sağlık sorunu olmaya devam etmektedir. Liken Planus (LP) gibi otoimmün hastalıklar, HBV enfeksiyonuna bağlı olarak hastalarda ortaya çıkabilmektedir. Bu yazıda, HBV DNA pozitifliği polimeraz zincir reaksiyonu (PCR) yöntemiyle doğrulanmış kronik HBV enfeksiyonu öyküsü bulunan ve klinik olarak LP semptomları gelişen bir olgu sunulmaktadır. Hastanın kronik HBV enfeksiyonu nedeniyle antiviral tedavi almakta olduğu bilinmektedir. Sonuç olarak, Liken Planus ile HBV enfeksiyonu arasındaki olası ilişki klinik verilerle desteklenmekle birlikte, bu ilişkinin altında yatan mekanizmalar henüz tam olarak aydınlatılamamıştır. Bu ilişkinin kapsamlı şekilde ortaya konulabilmesi ve özellikle endemik bölgelerde tarama ve yönetim stratejilerinin geliştirilmesi amacıyla daha geniş hasta popülasyonlarını içeren ileri araştırmalara ihtiyaç duyulmaktadır.

Keywords

Hepatit B virüsü , Lichen planus , antiviral ajanlar

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