Effects of Autapse and Channel Blockage on Firing Regularity in a Biological Neuronal Network

Year 2017, Volume: 17 Issue: 1, 3075 - 3081, 27.03.2017

Rukiye Uzun , Mahmut Ozer

Abstract

In this paper; the effects of
autapse (a kind of self-synapse formed between the axon of the soma of a neuron
and its own dendrites) and ion channel blockage on the firing regularity of a
biological small-world neuronal network, consists of stochastic Hodgkin-Huxley
neurons, are studied. In this study, it is assumed that all of the neurons on
the network have a chemical autapse and a constant membrane area. Obtained
results indicate that there are different effects of channel blockage and
parameters of the autapse on the regularity of the network, thus on the
temporal coherence of the network. It is found that the firing regularity of
the network is decreased with the sodium channel blockage while increased with
potassium channel blockage. Besides, it is determined that regularity of the
network augments with the conductance of the autapse.  

Keywords

Autapse, channel blocking, ion channel noise, small-world neuronal netwoks

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