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Year 2005, Volume: 38 , 47 - 56, 25.06.2013

P. İyidoğan, Z. Özdemir, B. Kandil .

https://izlik.org/JA52HC54GX

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SYNTHESİS OF SOME NEW 1,3,5-TRISUBSTITUTED PYRAZOLINES WITH ANTIDEPRESSANT AND ANTICONVULSANT ACTIVITIES

Year 2005, Volume: 38 , 47 - 56, 25.06.2013

P. İyidoğan, Z. Özdemir, B. Kandil .

https://izlik.org/JA52HC54GX

Abstract

1-Fenil-, 1-tiyokarbamoil-, 1-N-sübstitüe tiyokarbamoil- ve l-(4'-feniltiyazol-2'-il)-3-(2-naftil)-5-fenil/(2-furil)-2-pirazolin yapısında oniki bileşiğin sentezi yapılıp, antidepresan ve antikonvülsan aktiviteleri incelenmiştir. Maddelerin yapıları spektral bulgular ve elemantel analizle kanıtlanmıştır. Antidepresan aktiviteler "zorla yüzdürme testi" uygulanarak incelenmiştir. 1,10,11 ve 12 numaralı maddeler referans antidepresan ilaç olarak kullanılan tranilsipromine eşit veya daha yüksek aktivite göstermişlerdir. Bileşiklerin antikonvülsan aktiviteleri ve nörotoksisiteleri, antiepileptik İlaç geliştirme (ADD) programına uygun olarak maksimal elektroşok kasılma (MES), subkütan metrazol (ScMet.) ve rotarod toksisite testleri ile tayin edilmiştir. 1, 2, 4, 7, 9,11 ve 12   numaralı bileşikler MES ve ScMet. testlerinde 30-300 mg/kg dozlarda aktif bulunmuştur; 7 ve 9 numaralı bileşikler ScMet.'e karşı 30 mg/kg dozda maksimum koruyucu etki gösteren bileşiklerdir.

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Primary Language Turkish
Authors

P. İyidoğan, Z. Özdemir, B. Kandil . This is me

Publication Date June 25, 2013
IZ https://izlik.org/JA52HC54GX
Published in Issue Year 2005 Volume: 38

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APA ., P. İ. Z. Ö. B. K. (2013). SYNTHESİS OF SOME NEW 1,3,5-TRISUBSTITUTED PYRAZOLINES WITH ANTIDEPRESSANT AND ANTICONVULSANT ACTIVITIES. Journal of Faculty of Pharmacy of Istanbul University, 38, 47-56. https://izlik.org/JA52HC54GX
AMA 1.. PİZÖBK. SYNTHESİS OF SOME NEW 1,3,5-TRISUBSTITUTED PYRAZOLINES WITH ANTIDEPRESSANT AND ANTICONVULSANT ACTIVITIES. Journal of Faculty of Pharmacy of Istanbul University. 2013;38:47-56. https://izlik.org/JA52HC54GX
Chicago ., P. İyidoğan, Z. Özdemir, B. Kandil. 2013. “SYNTHESİS OF SOME NEW 1,3,5-TRISUBSTITUTED PYRAZOLINES WITH ANTIDEPRESSANT AND ANTICONVULSANT ACTIVITIES”. Journal of Faculty of Pharmacy of Istanbul University 38 (June): 47-56. https://izlik.org/JA52HC54GX.
EndNote . PİZÖBK (June 1, 2013) SYNTHESİS OF SOME NEW 1,3,5-TRISUBSTITUTED PYRAZOLINES WITH ANTIDEPRESSANT AND ANTICONVULSANT ACTIVITIES. Journal of Faculty of Pharmacy of Istanbul University 38 47–56.
IEEE [1]P. İ. Z. Ö. B. K. ., “SYNTHESİS OF SOME NEW 1,3,5-TRISUBSTITUTED PYRAZOLINES WITH ANTIDEPRESSANT AND ANTICONVULSANT ACTIVITIES”, Journal of Faculty of Pharmacy of Istanbul University, vol. 38, pp. 47–56, June 2013, [Online]. Available: https://izlik.org/JA52HC54GX
ISNAD ., P. İyidoğan, Z. Özdemir, B. Kandil. “SYNTHESİS OF SOME NEW 1,3,5-TRISUBSTITUTED PYRAZOLINES WITH ANTIDEPRESSANT AND ANTICONVULSANT ACTIVITIES”. Journal of Faculty of Pharmacy of Istanbul University 38 (June 1, 2013): 47-56. https://izlik.org/JA52HC54GX.
JAMA 1.. PİZÖBK. SYNTHESİS OF SOME NEW 1,3,5-TRISUBSTITUTED PYRAZOLINES WITH ANTIDEPRESSANT AND ANTICONVULSANT ACTIVITIES. Journal of Faculty of Pharmacy of Istanbul University. 2013;38:47–56.
MLA ., P. İyidoğan, Z. Özdemir, B. Kandil. “SYNTHESİS OF SOME NEW 1,3,5-TRISUBSTITUTED PYRAZOLINES WITH ANTIDEPRESSANT AND ANTICONVULSANT ACTIVITIES”. Journal of Faculty of Pharmacy of Istanbul University, vol. 38, June 2013, pp. 47-56, https://izlik.org/JA52HC54GX.
Vancouver 1.P. İyidoğan, Z. Özdemir, B. Kandil . SYNTHESİS OF SOME NEW 1,3,5-TRISUBSTITUTED PYRAZOLINES WITH ANTIDEPRESSANT AND ANTICONVULSANT ACTIVITIES. Journal of Faculty of Pharmacy of Istanbul University [Internet]. 2013 Jun. 1;38:47-56. Available from: https://izlik.org/JA52HC54GX