SYNTHESİS OF SOME NEW 1,3,5-TRISUBSTITUTED PYRAZOLINES WITH ANTIDEPRESSANT AND ANTICONVULSANT ACTIVITIES

P. İyidoğan, Z. Özdemir, B. Kandil .

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SYNTHESİS OF SOME NEW 1,3,5-TRISUBSTITUTED PYRAZOLINES WITH ANTIDEPRESSANT AND ANTICONVULSANT ACTIVITIES

Abstract

1-Fenil-, 1-tiyokarbamoil-, 1-N-sübstitüe tiyokarbamoil- ve l-(4'-feniltiyazol-2'-il)-3-(2-naftil)-5-fenil/(2-furil)-2-pirazolin yapısında oniki bileşiğin sentezi yapılıp, antidepresan ve antikonvülsan aktiviteleri incelenmiştir. Maddelerin yapıları spektral bulgular ve elemantel analizle kanıtlanmıştır. Antidepresan aktiviteler "zorla yüzdürme testi" uygulanarak incelenmiştir. 1,10,11 ve 12 numaralı maddeler referans antidepresan ilaç olarak kullanılan tranilsipromine eşit veya daha yüksek aktivite göstermişlerdir. Bileşiklerin antikonvülsan aktiviteleri ve nörotoksisiteleri, antiepileptik İlaç geliştirme (ADD) programına uygun olarak maksimal elektroşok kasılma (MES), subkütan metrazol (ScMet.) ve rotarod toksisite testleri ile tayin edilmiştir. 1, 2, 4, 7, 9,11 ve 12 numaralı bileşikler MES ve ScMet. testlerinde 30-300 mg/kg dozlarda aktif bulunmuştur; 7 ve 9 numaralı bileşikler ScMet.'e karşı 30 mg/kg dozda maksimum koruyucu etki gösteren bileşiklerdir.

Keywords

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Details

Primary Language

Turkish

Subjects

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Journal Section

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Authors

P. İyidoğan, Z. Özdemir, B. Kandil . This is me

Publication Date

June 25, 2013

Submission Date

June 25, 2013

Acceptance Date

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Published in Issue

Year 2005 Volume: 38 Number: 0

IZ

https://izlik.org/JA52HC54GX

Cite

RIS / Bibtex

APA

., P. İ. Z. Ö. B. K. (2013). SYNTHESİS OF SOME NEW 1,3,5-TRISUBSTITUTED PYRAZOLINES WITH ANTIDEPRESSANT AND ANTICONVULSANT ACTIVITIES. Journal of Faculty of Pharmacy of Istanbul University, 38, 47-56. https://izlik.org/JA52HC54GX

AMA

1.. PİZÖBK. SYNTHESİS OF SOME NEW 1,3,5-TRISUBSTITUTED PYRAZOLINES WITH ANTIDEPRESSANT AND ANTICONVULSANT ACTIVITIES. Journal of Faculty of Pharmacy of Istanbul University. 2013;38:47-56. https://izlik.org/JA52HC54GX

Chicago

., P. İyidoğan, Z. Özdemir, B. Kandil. 2013. “SYNTHESİS OF SOME NEW 1,3,5-TRISUBSTITUTED PYRAZOLINES WITH ANTIDEPRESSANT AND ANTICONVULSANT ACTIVITIES”. Journal of Faculty of Pharmacy of Istanbul University 38 (June): 47-56. https://izlik.org/JA52HC54GX.

EndNote

. PİZÖBK (June 1, 2013) SYNTHESİS OF SOME NEW 1,3,5-TRISUBSTITUTED PYRAZOLINES WITH ANTIDEPRESSANT AND ANTICONVULSANT ACTIVITIES. Journal of Faculty of Pharmacy of Istanbul University 38 47–56.

IEEE

[1]P. İ. Z. Ö. B. K. ., “SYNTHESİS OF SOME NEW 1,3,5-TRISUBSTITUTED PYRAZOLINES WITH ANTIDEPRESSANT AND ANTICONVULSANT ACTIVITIES”, Journal of Faculty of Pharmacy of Istanbul University, vol. 38, pp. 47–56, June 2013, [Online]. Available: https://izlik.org/JA52HC54GX

ISNAD

., P. İyidoğan, Z. Özdemir, B. Kandil. “SYNTHESİS OF SOME NEW 1,3,5-TRISUBSTITUTED PYRAZOLINES WITH ANTIDEPRESSANT AND ANTICONVULSANT ACTIVITIES”. Journal of Faculty of Pharmacy of Istanbul University 38 (June 1, 2013): 47-56. https://izlik.org/JA52HC54GX.

JAMA

1.. PİZÖBK. SYNTHESİS OF SOME NEW 1,3,5-TRISUBSTITUTED PYRAZOLINES WITH ANTIDEPRESSANT AND ANTICONVULSANT ACTIVITIES. Journal of Faculty of Pharmacy of Istanbul University. 2013;38:47–56.

MLA

., P. İyidoğan, Z. Özdemir, B. Kandil. “SYNTHESİS OF SOME NEW 1,3,5-TRISUBSTITUTED PYRAZOLINES WITH ANTIDEPRESSANT AND ANTICONVULSANT ACTIVITIES”. Journal of Faculty of Pharmacy of Istanbul University, vol. 38, June 2013, pp. 47-56, https://izlik.org/JA52HC54GX.

Vancouver

1.P. İyidoğan, Z. Özdemir, B. Kandil . SYNTHESİS OF SOME NEW 1,3,5-TRISUBSTITUTED PYRAZOLINES WITH ANTIDEPRESSANT AND ANTICONVULSANT ACTIVITIES. Journal of Faculty of Pharmacy of Istanbul University [Internet]. 2013 Jun. 1;38:47-56. Available from: https://izlik.org/JA52HC54GX