DRUG RELEASE FROM PEG SUPPOSITORY BASES AND FROM THEIR COMBINATION WITH POLYMERS

Abstract

In vitro investigation was conducted to evaluate the drug (Metronidazole) release
from the formulation containing "PEG SUPPOSITORIES BASES" and its combination
with CMC and PVP. The experiments were conducted at various temperatures and at
rectal pH.
When the percentage of the dmg release was upto 65%, the rate of release vs time
was linear but with combinations (with PVP and CMC) the rate was only linear upto
50% drug release at 37 °C.
Linear relationship was also observed between average molecular weight of the
bases upto 50% release rate at temperatures 37 °C, 40 °C, and 45 °C.

Different drug release was not only dependant on the average molecular weight
but also the proportions of various PEG bases.

Key words: Ethylene glycol, Diethylene glycol, Tragacanth, Metronidazole,
Suppository bases.

Keywords

• -

DRUG RELEASE FROM PEG SUPPOSITORY BASES AND FROM THEIR COMBINATION WITH POLYMERS

Abstract

In vitro investigation was conducted to evaluate the drug (Metronidazole) release from the formulation containing "PEG SUPPOSITORIES BASES" and its combination with CMC and PVP. The experiments were conducted at various temperatures and at rectal pH. When the percentage of the dmg release was upto 65%, the rate of release vs time was linear but with combinations (with PVP and CMC) the rate was only linear upto 50% drug release at 37 "C. Linear relationship was also observed between average molecular weight of the bases upto 50% release rate at temperatures 37 "C, 40 "C, and 45 "C. Different drug release was not only dependant on the average molecular weight but also the proportions of various PEG bases.

Keywords

• Ethylene glycol,Diethylene glycol,Tragacanth,Metronidazole,Suppository bases.

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