ANTIMUSCARINIC EFFECTS OF AMITRIPTYLINE HCI AND OPIPRAMOLE HCI IN RAT ILEUM AND RAT DUODENUM

Abstract

Arnitriptyline, a tricyclic antidepressant which is mainly used for major
depression treatment, was investigated about its antimuscarinic effects and as a
result it was found generally non-selective and 100 fold less active than atropine
(1,2,3,4). There are no satisfactory information about opipramole's antirnuscarinic
activity and selectivity.
Experiments were based on measuring agonist and antagonist responses in
isolated tissues in physiological conditions.

Key words: Antimuscarinic activity, Tricyclic antidepressants, Arnitriptyline,
Opipramole.

Keywords

• -

ANTIMUSCARINIC EFFECTS OF AMITRIPTYLINE HCI AND OPIPRAMOLE HCI IN RAT ILEUM AND RAT DUODENUM

Abstract

Arnitriptyline, a tricyclic antidepressant which is mainly used for major depression treatment, was investigated about its antimuscarinic effects and as a result it was found generally non-selective and 100 fold less active than atropine (1,2,3,4). There are no satisfactory information about opipramole's antirnuscarinic activity and selectivity. Experiments were based on measuring agonist and antagonist responses in isolated tissues in physiological conditions.

Keywords

• Antimuscarinic activity,Tricyclic antidepressant,Arnitriptyline,Opipramole

References

1. I. Reynolds, J.E.F., Parfitt, K., Parsons, A.V., Sweetman, S.C., Antidepressants in: Martindale, The Extra Pharmacopoeia, Thirtieth edition, The Pharmaceutical Press, London, UK, pp. 243-275 (1993).
2. 2.. Richelson, E., Antimuscarinic and other receptor blocking properties of antidepressants, Mayo Clin. Proc., 58,40-6 (1983).
3. 3. Kayaalp, O., Antidepresan ve antimanik ila~lar, 68,947-86 (1992).
4. 4. Kwok, Y.H., Mitchelson, F., The effect of amitriptyline, mianserin and viloxazine at preand postjunctional muscarinic receptors in guinea pig ileal longitudinal muscle, Can. J. Pllysiol. and Pharmacol., 60, 193-200 (1982).
5. 5. Hammer, R., Giachetti, A., Selective muscarinic receptor antagonists, Tretzds in pharnzacol. Sci. , . . .., 18-20 (1984).
6. 6. Hulme, E.C. , Birdsall, N.J.M., Buckley N.J., Muscarinic receptor subtypes , Antzu. Rev. Plmrmacol. Toxicol., 30,633-673 (1990).
7. 7. Mutschler, E., Feifel, R., Moser, U., Tacke, R., WessJ., ~ambrecht, G., Muscarinic receptor a subtypes, Eltr. J. Pharnlacol, 183, 1 17-1 19 (1990).
8. 8. Mutschler, E., Lambrecht, G., Selective muscarinic agonists and antagonists in functional tests, Trends in Pharnlacol. Sci., (suppl) 5,39-44 (1984).

9. 9. Kachur, J.F., Albee, W.E. , Gaginella, T.S., Antihistaminic and antimuscarinic effects of amitriptyline on guinea pig ileal electrolyte transport and muscle contractility in vitro , J. Pllarnzacol. Exp. Tlzer., 245,455-459 (1988).
10. 10. McKinney, M., Lee, N.H., Anderson, D.J., Wella-Rountree, L., El-Fakahany, E.E., Non-selectivity of amitriptyline for subtypes of brain muscarinic receptors demostrating in binding and functional assays, Eur.J Phartnacol., 157,51-60 (1988)
11. 11. Richardson, J.S., Mattio, T.G., Giacabini, E., Amitriptyline and imipramine inhibit the release of acetylcholine from parasympathetic nerve terminals in the rat iris, Can. J. Plzysiol. Phuimacol., 62,857-859 (1 984).