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The role of perivascular adipose tissue on human saphenous vein vascular tone

Year 2016, Volume 46, Issue 1, 1 - 13, 24.08.2016

Abstract

Perivascular adipose tissue (PVAT) is situated outside of almost every blood vessel. Recent studies showed that PVAT provides mechanical support for blood vessels and secretes vasoactive adipokines that could regulate vascular tone. However, most of the studies evaluating PVAT effects on vascular tone have been performed with vessels derived from animals. Therefore, we aimed to investigate the role of PVAT surrounding human coronary bypass graft vessels such as saphenous vein (SV). Human SV preparations were set up in an organ bath in the presence or absence of their PVAT. The presence of PVAT significantly attenuated the contractile response to prostaglandin F2α (PGF2α). However, potassium chloride (KCI)-induced concentration-response curve wasn’t modified in PVAT-intact SV preparations. On the other hand, endothelium-dependent relaxation induced by acetylcholine (ACh) or endothelium-independent relaxation induced by sodium nitroprusside (SNP) were similar between SV with PVAT versus SV without PVAT preparations. Sensitivity of the SV to contractile agonists (KCI, PGF2α) or relaxant agonists (SNP, ACh) were not modified in the presence of PVAT. These results suggest that PVAT could decrease PGF2α-induced contractile tone via endothelium-independent mechanisms in SV. Retaining PVAT in SV preparations during bypass graft surgery could prevent graft vasospasm possibly via PVAT derived relaxant factor(s).

References

  • Bunker AK, Laughlin MH (2010) Influence of exercise and perivascular adipose tissue on coronary artery vasomotor function in a familial hypercholesterolemic porcine atherosclerosis model, J. Appl. Physiol., 108: 490-497.
  • Dashwood MR, Tsui JC (2013) No-touch’saphenous vein harvesting improves graft performance in patients undergoing coronary artery bypass surgery: A journey from bedside to bench, Vas. Pharmacol., 58: 240-250.
  • Galvez B, de Castro J, Herold D, Dubrovska G, Arribas S, Gonzalez MC, Aranguez I, Luft FC, Ramos MP, Gollasch M, Fernandez Alfonso MS (2006) Perivascular adipose tissue and mesenteric vascular function in spontaneously hypertensive rats, Arterioscler. Thromb. Vasc. Biol., 26: 1297-1302.
  • Gao YJ, Zeng ZH, Teoh K, Sharma AM, Abouzahr L, Cybulsky I, Lamy A, Semelhago L, Lee RM (2005) Perivascular adipose tissue modulates vascular function in the human internal thoracic artery, J. Thorac. Cardiovasc. Surg., 130: 1130-1136.
  • Gao YJ, Lu C, Su LY, Sharma AM, Lee RM (2007) Modulation of vascular function by perivascular adipose tissue: the role of endothelium and hydrogen peroxide, Br. J. Pharmacol., 151: 323-31.
  • Lohn M, Dubrovska G, Lauterbach B, Luft FC, Gollasch M, Sharma AM (2002) Periadventitial fat releases a vascular relaxing factor, FASEB J., 16: 1057-1063.
  • Lu C, Zhao AX, Gao YJ, Lee RM (2011) Modulation of vein function by perivascular adipose tissue, Eur. J. Pharmacol., 657: 111-116.
  • Malinowski M, Deja MA, Golba KS, Roleder T, Biernat J, Wos S (2008) Perivascular tissue of internal thoracic artery releases potent nitric oxide and prostacyclin-independent anticontractile factor, Eur. J. Cardiothorac. Surg., 33: 225-231.
  • Oriowo MA (2015) Perivascular adipose tissue, vascular reactivity and hypertension, Med. Princ. Pract., 24: 29-37.
  • Ozen G, Topal G, Gomez I, Ghorreshi A, Boukais K, Benyahia C, Kanyinda L, Longrois D, Teskin O, Uydes-Dogan BS, Norel X (2013) Control of human vascular tone by prostanoids derived from perivascular adipose tissue, Prostaglandins. Other. Lipid. Mediat.,107:13-17.
  • Ozen G, Daci A, Norel X, Topal G (2015) Human perivascular adipose tissue dysfunction as a cause of vascular disease: Focus on vascular tone and wall remodeling, Eur. J. Pharmacol., 766: 16-24.
  • Pearl JM, Manning PB, McNamara JL, Saucier MM, Thomas DW (1999) Effect of modified ultrafiltration on plasma thromboxane B2, leukotriene B4, and endothelin-1 in infants undergoing cardiopulmonary bypass, Ann. Thorac. Surg., 68: 1369-1375.
  • Sen O, Gonca S, Solakoglu S, Dalcik H, Dalcik C, Ozkara A (2013) Comparison of conventional and no-touch techniques in harvesting saphenous vein for coronary artery bypass grafting in view of endothelial damage, Heart. Surg. Forum., 16: 177-183.
  • Sepehripour AH, Jarral OA, Shipolini AR, McCormack DJ (2011) Does a ‘no-touch’ technique result in better vein patency, Interact. Cardiovasc. Thorac. Surg., 13: 626-630.
  • Soltis EE, Cassis LA (1991) Influence of perivascular adipose tissue on rat aortic smooth muscle responsiveness, Clin. Exp. Hypertens. A., 13: 277-296.
  • Souza DS, Bomfim V, Skoglund H, Dashwood MR, Borowiec JW, Bodin L, Filbey D (2001) High early patency of saphenous vein graft for coronary artery bypass harvested with surrounding tissue, Ann. Thorac. Surg., 71: 797-800.
  • Szasz T, Bomfim GF, Webb RC (2013) The influence of perivascular adipose tissue on vascular homeostasis, Vasc. Health. Risk. Manag., 9: 105-116.
  • Takemori K, Gao YJ, Ding L, Lu C, Su LY, An WS, Vinson C, Lee RM (2007) Elevated blood pressure in transgenic lipoatrophic mice and altered vascular function, Hypertension., 49: 365-372.

Year 2016, Volume 46, Issue 1, 1 - 13, 24.08.2016

Abstract

References

  • Bunker AK, Laughlin MH (2010) Influence of exercise and perivascular adipose tissue on coronary artery vasomotor function in a familial hypercholesterolemic porcine atherosclerosis model, J. Appl. Physiol., 108: 490-497.
  • Dashwood MR, Tsui JC (2013) No-touch’saphenous vein harvesting improves graft performance in patients undergoing coronary artery bypass surgery: A journey from bedside to bench, Vas. Pharmacol., 58: 240-250.
  • Galvez B, de Castro J, Herold D, Dubrovska G, Arribas S, Gonzalez MC, Aranguez I, Luft FC, Ramos MP, Gollasch M, Fernandez Alfonso MS (2006) Perivascular adipose tissue and mesenteric vascular function in spontaneously hypertensive rats, Arterioscler. Thromb. Vasc. Biol., 26: 1297-1302.
  • Gao YJ, Zeng ZH, Teoh K, Sharma AM, Abouzahr L, Cybulsky I, Lamy A, Semelhago L, Lee RM (2005) Perivascular adipose tissue modulates vascular function in the human internal thoracic artery, J. Thorac. Cardiovasc. Surg., 130: 1130-1136.
  • Gao YJ, Lu C, Su LY, Sharma AM, Lee RM (2007) Modulation of vascular function by perivascular adipose tissue: the role of endothelium and hydrogen peroxide, Br. J. Pharmacol., 151: 323-31.
  • Lohn M, Dubrovska G, Lauterbach B, Luft FC, Gollasch M, Sharma AM (2002) Periadventitial fat releases a vascular relaxing factor, FASEB J., 16: 1057-1063.
  • Lu C, Zhao AX, Gao YJ, Lee RM (2011) Modulation of vein function by perivascular adipose tissue, Eur. J. Pharmacol., 657: 111-116.
  • Malinowski M, Deja MA, Golba KS, Roleder T, Biernat J, Wos S (2008) Perivascular tissue of internal thoracic artery releases potent nitric oxide and prostacyclin-independent anticontractile factor, Eur. J. Cardiothorac. Surg., 33: 225-231.
  • Oriowo MA (2015) Perivascular adipose tissue, vascular reactivity and hypertension, Med. Princ. Pract., 24: 29-37.
  • Ozen G, Topal G, Gomez I, Ghorreshi A, Boukais K, Benyahia C, Kanyinda L, Longrois D, Teskin O, Uydes-Dogan BS, Norel X (2013) Control of human vascular tone by prostanoids derived from perivascular adipose tissue, Prostaglandins. Other. Lipid. Mediat.,107:13-17.
  • Ozen G, Daci A, Norel X, Topal G (2015) Human perivascular adipose tissue dysfunction as a cause of vascular disease: Focus on vascular tone and wall remodeling, Eur. J. Pharmacol., 766: 16-24.
  • Pearl JM, Manning PB, McNamara JL, Saucier MM, Thomas DW (1999) Effect of modified ultrafiltration on plasma thromboxane B2, leukotriene B4, and endothelin-1 in infants undergoing cardiopulmonary bypass, Ann. Thorac. Surg., 68: 1369-1375.
  • Sen O, Gonca S, Solakoglu S, Dalcik H, Dalcik C, Ozkara A (2013) Comparison of conventional and no-touch techniques in harvesting saphenous vein for coronary artery bypass grafting in view of endothelial damage, Heart. Surg. Forum., 16: 177-183.
  • Sepehripour AH, Jarral OA, Shipolini AR, McCormack DJ (2011) Does a ‘no-touch’ technique result in better vein patency, Interact. Cardiovasc. Thorac. Surg., 13: 626-630.
  • Soltis EE, Cassis LA (1991) Influence of perivascular adipose tissue on rat aortic smooth muscle responsiveness, Clin. Exp. Hypertens. A., 13: 277-296.
  • Souza DS, Bomfim V, Skoglund H, Dashwood MR, Borowiec JW, Bodin L, Filbey D (2001) High early patency of saphenous vein graft for coronary artery bypass harvested with surrounding tissue, Ann. Thorac. Surg., 71: 797-800.
  • Szasz T, Bomfim GF, Webb RC (2013) The influence of perivascular adipose tissue on vascular homeostasis, Vasc. Health. Risk. Manag., 9: 105-116.
  • Takemori K, Gao YJ, Ding L, Lu C, Su LY, An WS, Vinson C, Lee RM (2007) Elevated blood pressure in transgenic lipoatrophic mice and altered vascular function, Hypertension., 49: 365-372.

Details

Subjects Pharmacology and Pharmacy
Journal Section Araştırma Makalesi
Authors

Gülsev ÖZEN This is me


B. Sönmez UYDEŞ DOĞAN>


Önder TESKİN This is me


Xavier NOREL This is me


Gökçe TOPAL>

Publication Date August 24, 2016
Published in Issue Year 2016, Volume 46, Issue 1

Cite

Bibtex @research article { iujfp284531, journal = {Journal of Faculty of Pharmacy of Istanbul University}, issn = {0367-7524}, eissn = {2148-6042}, address = {}, publisher = {Istanbul University}, year = {2016}, volume = {46}, number = {1}, pages = {1 - 13}, title = {The role of perivascular adipose tissue on human saphenous vein vascular tone}, key = {cite}, author = {Özen, Gülsev and Uydeş Doğan, B. Sönmez and Teskin, Önder and Norel, Xavier and Topal, Gökçe} }
APA Özen, G. , Uydeş Doğan, B. S. , Teskin, Ö. , Norel, X. & Topal, G. (2016). The role of perivascular adipose tissue on human saphenous vein vascular tone . Journal of Faculty of Pharmacy of Istanbul University , 46 (1) , 1-13 . Retrieved from https://dergipark.org.tr/en/pub/iujfp/issue/27028/284531
MLA Özen, G. , Uydeş Doğan, B. S. , Teskin, Ö. , Norel, X. , Topal, G. "The role of perivascular adipose tissue on human saphenous vein vascular tone" . Journal of Faculty of Pharmacy of Istanbul University 46 (2016 ): 1-13 <https://dergipark.org.tr/en/pub/iujfp/issue/27028/284531>
Chicago Özen, G. , Uydeş Doğan, B. S. , Teskin, Ö. , Norel, X. , Topal, G. "The role of perivascular adipose tissue on human saphenous vein vascular tone". Journal of Faculty of Pharmacy of Istanbul University 46 (2016 ): 1-13
RIS TY - JOUR T1 - The role of perivascular adipose tissue on human saphenous vein vascular tone AU - GülsevÖzen, B. SönmezUydeş Doğan, ÖnderTeskin, XavierNorel, GökçeTopal Y1 - 2016 PY - 2016 N1 - DO - T2 - Journal of Faculty of Pharmacy of Istanbul University JF - Journal JO - JOR SP - 1 EP - 13 VL - 46 IS - 1 SN - 0367-7524-2148-6042 M3 - UR - Y2 - 2022 ER -
EndNote %0 Journal of Faculty of Pharmacy of Istanbul University The role of perivascular adipose tissue on human saphenous vein vascular tone %A Gülsev Özen , B. Sönmez Uydeş Doğan , Önder Teskin , Xavier Norel , Gökçe Topal %T The role of perivascular adipose tissue on human saphenous vein vascular tone %D 2016 %J Journal of Faculty of Pharmacy of Istanbul University %P 0367-7524-2148-6042 %V 46 %N 1 %R %U
ISNAD Özen, Gülsev , Uydeş Doğan, B. Sönmez , Teskin, Önder , Norel, Xavier , Topal, Gökçe . "The role of perivascular adipose tissue on human saphenous vein vascular tone". Journal of Faculty of Pharmacy of Istanbul University 46 / 1 (August 2016): 1-13 .
AMA Özen G. , Uydeş Doğan B. S. , Teskin Ö. , Norel X. , Topal G. The role of perivascular adipose tissue on human saphenous vein vascular tone. Journal of Faculty of Pharmacy of Istanbul University. 2016; 46(1): 1-13.
Vancouver Özen G. , Uydeş Doğan B. S. , Teskin Ö. , Norel X. , Topal G. The role of perivascular adipose tissue on human saphenous vein vascular tone. Journal of Faculty of Pharmacy of Istanbul University. 2016; 46(1): 1-13.
IEEE G. Özen , B. S. Uydeş Doğan , Ö. Teskin , X. Norel and G. Topal , "The role of perivascular adipose tissue on human saphenous vein vascular tone", Journal of Faculty of Pharmacy of Istanbul University, vol. 46, no. 1, pp. 1-13, Aug. 2016