Electrospinning method to produce drug-loaded nanofibers for topical/ transdermal drug delivery applications

Year 2016, Volume: 46 Issue: 1, 49 - 69, 24.08.2016

İmren Esentürk M. Sedef Erdal Sevgi Güngör

Abstract

Electrospinning is the method for preparing drug-loaded nanofibers with ultrafine structure, a large surface area to volume ratio, and a high porosity with a small pore size. Among the other nanofiber production methods, electrospinning is the most cost effective one with simple tooling and, it is applicable to produce ultrafine fibers with a simple step-up production for drug delivery applications.The selection of the polymer as carrier for electrospinning and the production procedure design is crucial due to drug-polymer-solvent interactions and the other process parameters which would influence the physicochemical biocompatibilityand characteristics.This technique can be applied to produce nanofibers of a wide array of polymer types: natural, synthetic polymers, or their blends.This review focuses on various electrospinning methods to produce drug loaded nanofibers, polymers used, electrospinning process parameters, their advantages and limitations for topical/transdermal drug delivery applications.

Keywords

Nanofiber, electrospinning, topical drug delivery, transdermal drug delivery

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