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Year 1969, Volume: 5 , 80 - 90, 25.06.2013

Abstract

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Antihistaminik Madde İhtiva Eden İlaçların Kantitatif İnce Tabaka Kromatografisi

Year 1969, Volume: 5 , 80 - 90, 25.06.2013

Abstract

The wide-spread use of antihistaminic preparations has resulted, in the development of analytical techniques for the identification and assay of these compounds.

Macek and Vacerkovatl) used paper and thin-layer chromatogra­phy, Gendi et al. (2), Fike and Sunshine C3) used thin-layer chroma­tographic technique for the identification of antihistamines.

As the usual color reactions for detection of the antihistamine spots are based on the reactions of amine group or intracyclic nit-rogene, Dragendorf f reagent (4), p-dimethylaminobenzaldehyde (4), eerie sulfate (5), Pauly reagent, potassium iodoplatinate, ammonium vanadate-sulfuric acid were used for this purpose.

Different methods were proposed for the quantitative determina­tion of antihistamines. The United States Pharmacopeia (6) and the British Pharmacopoeia (7) utilize nonaqueous titrimetric or ultraviolet spectrophotometric methods. Blaug and Zopf(8) proposed an ion ex­change separation for the determination of diphenhydramine HC1, doxylamine HC1, chlorpheniramine maleate and tripellenamine HC1, alone or in pharmaceutical preparations. Morrison and Chatteni5) proposed a quantitative thin-layer technique which is based on the careful measurement of spot area from which the concentration of the substance can be calculated.

This paper deals with the identification by TLC and estimation by quantitative thin-layer technique of the below mentioned antihis­tamines in solution or in multicomponent pharmaceuticals.

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Details

Primary Language Turkish
Journal Section Makaleler
Authors

Serpil Demir Ve Hayriye ã‚mal . This is me

Publication Date June 25, 2013
Published in Issue Year 1969 Volume: 5

Cite

APA ., S. D. V. H. ã. (2013). Antihistaminik Madde İhtiva Eden İlaçların Kantitatif İnce Tabaka Kromatografisi. Journal of Faculty of Pharmacy of Istanbul University, 5, 80-90.
AMA . SDVHã. Antihistaminik Madde İhtiva Eden İlaçların Kantitatif İnce Tabaka Kromatografisi. Journal of Faculty of Pharmacy of Istanbul University. June 2013;5:80-90.
Chicago ., Serpil Demir Ve Hayriye ã‚mal. “Antihistaminik Madde İhtiva Eden İlaçların Kantitatif İnce Tabaka Kromatografisi”. Journal of Faculty of Pharmacy of Istanbul University 5, June (June 2013): 80-90.
EndNote . SDVHã (June 1, 2013) Antihistaminik Madde İhtiva Eden İlaçların Kantitatif İnce Tabaka Kromatografisi. Journal of Faculty of Pharmacy of Istanbul University 5 80–90.
IEEE S. D. V. H. ã. ., “Antihistaminik Madde İhtiva Eden İlaçların Kantitatif İnce Tabaka Kromatografisi”, Journal of Faculty of Pharmacy of Istanbul University, vol. 5, pp. 80–90, 2013.
ISNAD ., Serpil Demir Ve Hayriye ã‚mal. “Antihistaminik Madde İhtiva Eden İlaçların Kantitatif İnce Tabaka Kromatografisi”. Journal of Faculty of Pharmacy of Istanbul University 5 (June 2013), 80-90.
JAMA . SDVHã. Antihistaminik Madde İhtiva Eden İlaçların Kantitatif İnce Tabaka Kromatografisi. Journal of Faculty of Pharmacy of Istanbul University. 2013;5:80–90.
MLA ., Serpil Demir Ve Hayriye ã‚mal. “Antihistaminik Madde İhtiva Eden İlaçların Kantitatif İnce Tabaka Kromatografisi”. Journal of Faculty of Pharmacy of Istanbul University, vol. 5, 2013, pp. 80-90.
Vancouver . SDVHã. Antihistaminik Madde İhtiva Eden İlaçların Kantitatif İnce Tabaka Kromatografisi. Journal of Faculty of Pharmacy of Istanbul University. 2013;5:80-9.