Abstract
The wide-spread use of antihistaminic preparations has resulted, in the development of analytical techniques for the identification and assay of these compounds.
Macek and Vacerkovatl) used paper and thin-layer chromatography, Gendi et al. (2), Fike and Sunshine C3) used thin-layer chromatographic technique for the identification of antihistamines.
As the usual color reactions for detection of the antihistamine spots are based on the reactions of amine group or intracyclic nit-rogene, Dragendorf f reagent (4), p-dimethylaminobenzaldehyde (4), eerie sulfate (5), Pauly reagent, potassium iodoplatinate, ammonium vanadate-sulfuric acid were used for this purpose.
Different methods were proposed for the quantitative determination of antihistamines. The United States Pharmacopeia (6) and the British Pharmacopoeia (7) utilize nonaqueous titrimetric or ultraviolet spectrophotometric methods. Blaug and Zopf(8) proposed an ion exchange separation for the determination of diphenhydramine HC1, doxylamine HC1, chlorpheniramine maleate and tripellenamine HC1, alone or in pharmaceutical preparations. Morrison and Chatteni5) proposed a quantitative thin-layer technique which is based on the careful measurement of spot area from which the concentration of the substance can be calculated.
This paper deals with the identification by TLC and estimation by quantitative thin-layer technique of the below mentioned antihistamines in solution or in multicomponent pharmaceuticals.
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| Primary Language | Turkish |
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| Journal Section | Makaleler |
| Authors | |
| Publication Date | June 25, 2013 |
| Published in Issue | Year 1969 Volume: 5 |