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SPECTROPHOTOMETRIC DETERMINATION OF MIRTAZAPINE IN PURE AND TABLET PHARMACEUTICAL PREPARATION

Year 2012, Volume: 2 Issue: 42(2), 77 - 82, 10.01.2014

E. Kel Özdemir S. Tatar Ulu D. Özer Ünal E. Kel Özdemir, S. Tatar Ulu*, D. Öze E. Kel Özdemir, S. Tatar Ulu*, D. Özer Ünal

Abstract

Sensitive spectrophotometric method was developed for the determination of mirtazapine from pharmaceutical preparats. The proposed method was based on the formation of a yellow colored ion-pair complex by the reaction of methyl orange with mirtazapine. The ion pair complex was extracted with dichloromethane. Under the optimum condition, the ion pair complex showed an absorption maximum at 427 nm. The linearity range for concentrations of mirtazapine was found to be 2.5-12.5 μg/mL. The proposed method is successfully applied to the determination of mirtazapine tablet formulations.

Keywords

SPECTROPHOTOMETRIC DETERMINATION MIRTAZAPINE

References

  • Holm, K.J., Markham, A., Drugs 57, 607-631 (1999).
  • Karasen, N., Altinoz, S., Journal of Pharmaceutical and Biomedical Analysis, 24, 11-17(2000).
  • Labat, L., Dallet, P., Kummer, E., Dubost, J.P., Journal of Pharmaceutical and Biomedical Analysis, 28, 365–371 (2002).
  • Rao RN. Raju AN., J. Chromatogr Sci, 47(3): 223-30 (2009)
  • Gondova T. Petrikova I., J AOAC Int. May-Jun; 93 (3): 778-82 (2010).
  • Wynia GS. Windhorst G., Post PC., Moris FA., J Chromatogr A, 773, 339-350, (1997).
  • Keldir J., Funke C., De Boer T., Delbressine L., et. all., J. Pharm Pharmacol 49, 403-407, (1997).

SPECTROPHOTOMETRIC DETERMINATION OF MIRTAZAPINE IN PURE AND TABLET PHARMACEUTICAL PREPARATION

Year 2012, Volume: 2 Issue: 42(2), 77 - 82, 10.01.2014

E. Kel Özdemir S. Tatar Ulu D. Özer Ünal E. Kel Özdemir, S. Tatar Ulu*, D. Öze E. Kel Özdemir, S. Tatar Ulu*, D. Özer Ünal

Abstract

Mirtazapinin farmasötik preparatlarda tayini için duyarlı spektrofotometrik
bir yöntem geliştirilmiştir. Geliştirilen yöntem, mirtazapin ile metil oranj
arasında sarı renkli iyon çifti kompleksi oluşturması esasına dayanmaktadır.
İyon çifti kompleksi diklormetan ile ekstre edilmiştir. Optimize edilmiş
koşullarda iyon çifti kompleksinin maksimum absorbsiyon değeri 427 nm
olarak tespit edilmiştir. Mirtazapinin doğrusallık aralığı 2.5-12.5 μg/mL
olarak bulunmuştur. Geliştirilen yöntemin tabletlerde mirtazapin miktar
tayininde güvenle uygulanabilir.

References

  • Holm, K.J., Markham, A., Drugs 57, 607-631 (1999).
  • Karasen, N., Altinoz, S., Journal of Pharmaceutical and Biomedical Analysis, 24, 11-17(2000).
  • Labat, L., Dallet, P., Kummer, E., Dubost, J.P., Journal of Pharmaceutical and Biomedical Analysis, 28, 365–371 (2002).
  • Rao RN. Raju AN., J. Chromatogr Sci, 47(3): 223-30 (2009)
  • Gondova T. Petrikova I., J AOAC Int. May-Jun; 93 (3): 778-82 (2010).
  • Wynia GS. Windhorst G., Post PC., Moris FA., J Chromatogr A, 773, 339-350, (1997).
  • Keldir J., Funke C., De Boer T., Delbressine L., et. all., J. Pharm Pharmacol 49, 403-407, (1997).
There are 7 citations in total.

Details

Primary Language English
Subjects Pharmacology and Pharmaceutical Sciences
Journal Section Makaleler
Authors

E. Kel Özdemir This is me

S. Tatar Ulu This is me

D. Özer Ünal This is me

E. Kel Özdemir, S. Tatar Ulu*, D. Öze E. Kel Özdemir, S. Tatar Ulu*, D. Özer Ünal This is me

Publication Date January 10, 2014
Published in Issue Year 2012 Volume: 2 Issue: 42(2)

Cite

APA Kel Özdemir, E., Tatar Ulu, S., Özer Ünal, D., E. Kel Özdemir, S. Tatar Ulu*, D. Özer Ünal, E. K. Ö. S. T. U. D. Ö. (2014). SPECTROPHOTOMETRIC DETERMINATION OF MIRTAZAPINE IN PURE AND TABLET PHARMACEUTICAL PREPARATION. Journal of Faculty of Pharmacy of Istanbul University, 2(42(2), 77-82.
AMA Kel Özdemir E, Tatar Ulu S, Özer Ünal D, E. Kel Özdemir, S. Tatar Ulu*, D. Özer Ünal EKÖSTUDÖ. SPECTROPHOTOMETRIC DETERMINATION OF MIRTAZAPINE IN PURE AND TABLET PHARMACEUTICAL PREPARATION. Journal of Faculty of Pharmacy of Istanbul University. January 2014;2(42(2):77-82.
Chicago Kel Özdemir, E., S. Tatar Ulu, D. Özer Ünal, and E. Kel Özdemir, S. Tatar Ulu*, D. Öze E. Kel Özdemir, S. Tatar Ulu*, D. Özer Ünal. “SPECTROPHOTOMETRIC DETERMINATION OF MIRTAZAPINE IN PURE AND TABLET PHARMACEUTICAL PREPARATION”. Journal of Faculty of Pharmacy of Istanbul University 2, no. 42(2) (January 2014): 77-82.
EndNote Kel Özdemir E, Tatar Ulu S, Özer Ünal D, E. Kel Özdemir, S. Tatar Ulu*, D. Özer Ünal EKÖSTUDÖ (January 1, 2014) SPECTROPHOTOMETRIC DETERMINATION OF MIRTAZAPINE IN PURE AND TABLET PHARMACEUTICAL PREPARATION. Journal of Faculty of Pharmacy of Istanbul University 2 42(2) 77–82.
IEEE E. Kel Özdemir, S. Tatar Ulu, D. Özer Ünal, and E. K. Ö. S. T. U. D. Ö. E. Kel Özdemir, S. Tatar Ulu*, D. Özer Ünal, “SPECTROPHOTOMETRIC DETERMINATION OF MIRTAZAPINE IN PURE AND TABLET PHARMACEUTICAL PREPARATION”, Journal of Faculty of Pharmacy of Istanbul University, vol. 2, no. 42(2), pp. 77–82, 2014.
ISNAD Kel Özdemir, E. et al. “SPECTROPHOTOMETRIC DETERMINATION OF MIRTAZAPINE IN PURE AND TABLET PHARMACEUTICAL PREPARATION”. Journal of Faculty of Pharmacy of Istanbul University 2/42(2) (January 2014), 77-82.
JAMA Kel Özdemir E, Tatar Ulu S, Özer Ünal D, E. Kel Özdemir, S. Tatar Ulu*, D. Özer Ünal EKÖSTUDÖ. SPECTROPHOTOMETRIC DETERMINATION OF MIRTAZAPINE IN PURE AND TABLET PHARMACEUTICAL PREPARATION. Journal of Faculty of Pharmacy of Istanbul University. 2014;2:77–82.
MLA Kel Özdemir, E. et al. “SPECTROPHOTOMETRIC DETERMINATION OF MIRTAZAPINE IN PURE AND TABLET PHARMACEUTICAL PREPARATION”. Journal of Faculty of Pharmacy of Istanbul University, vol. 2, no. 42(2), 2014, pp. 77-82.
Vancouver Kel Özdemir E, Tatar Ulu S, Özer Ünal D, E. Kel Özdemir, S. Tatar Ulu*, D. Özer Ünal EKÖSTUDÖ. SPECTROPHOTOMETRIC DETERMINATION OF MIRTAZAPINE IN PURE AND TABLET PHARMACEUTICAL PREPARATION. Journal of Faculty of Pharmacy of Istanbul University. 2014;2(42(2):77-82.
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