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Adverse effects of counterfeit drugs on public health

Year 2014, Volume: 44 Issue: 1, 89 - 99, 29.01.2015

Abstract

In the last decades, growing number of counterfeit pharmaceuticals involve to global pharmaceutical market. The counterfeited drugs are substandard, poor quality copies of original products, so they pose a global and serious health risk which can lead to resistance to treatment, illness, disability and even death. Recently in Turkey, a counterfeit cancer drug has been realized from its package and it was reported that 95 patients did not get the treatment they supposed. Moreover, it is understood that, they are marketed not even in Turkey but also to the global market. Counterfeiting is a crime and a problem of all countries even developed or underdeveloped. Pharmacist and all healthcare professionals should be knowledgeable and vigilant on the importance of the adverse effects of counterfeited drugs. In this review, we have tried to draw attention to counterfeit drugs and their adverse effects on public health

References

  • WHO, World Health Organization. General information on counterfeit medicines. Available at: http://www.who.int/medicines/services/counterfeit/overview/enAc- cessed date: 18 Dec 2013.
  • Editorial, Strengthening global action against poor quality drugs, Lancet 381(9867), 599, 2013.
  • EAASM 2008, The Counterfeiting Superhighway, Available at: http://www.eaasm.eu/ cache/downloads/dqqt3sge9hwssgcgcos440g40/455_EAASM_counterfeiting%20 report_020608(1).pdfAccessed date: 16 Jan 2014.
  • WHO 2010, Global status report on noncommunicable diseases, Available at: http:// www.who.int/nmh/publications/ncd_report_full_en.pdf. Accessed date: 16 Jan 2014.
  • Kozma CM, Reeder CE, Schulz RM, Economic, clinical, and humanistic outcomes: a planning model for pharmacoeconomic research, Clin Ther 15(6), 1121-32, 1993.
  • Oy B, Fake and Counterfeit Drug: A review, Afrimedic Journal 3(2), 1-4, 2012.
  • Bate R, Hess, Assessing Website Pharmacy Drug Quality: safer than You Think, PLoS One, 5(8), e12199, 2010.
  • Dean J, Klep R, Aquilina JW. Counterfeit dapoxetine sold on the Internet contains undis- closed sildenafil, Int J Clin Pract 64(9), 1319-22, 2010.
  • Chaubey SK, Sangla KS, Suthaharan EN, Tan YM. Severe hypoglycaemia associated with ingesting counterfeit medication, Med J, 192(12), 716-7, 2010.
  • Soltaninejad K, Faryadi M, Akhgari M, Bahmanabadi L. Chemical profile of counter- feit buprenorphine vials seized in Tehran, Iran. Forensic Sci Int 172(2-3), e4-5, 2007.
  • Hürriyet Daily News, Çete 30 ilacın sahtesini Türkiye’de yapıp dünyaya yaydı. Available at: http://www.hurriyet.com.tr/ekonomi/25337903.aspAccessed date: 14 Dec 2013.
  • Nair A, Strauch S, Lauwo J, Jähnke RW, Dressman J, Are counterfeit or substandard anti-infective products the cause of treatment failure in Papua New Guinea? J Pharm Sci 100(11), 5059-68, 2011.
  • Ortiz RS, Mariotti Kde C, Holzschuh MH, Romão W, Limberger RP, Mayorga P, Pro- filing counterfeit Cialis, Viagra and analogs by UPLC-MS, Forensic Sci Int 229(1-3), 13-20, 2013.
  • Venhuis BJ, Zwaagstra ME, Keizers PH, de Kaste D, Dose-to-dose variations with single packages of counterfeit medicines and adulterated dietary supplements as a potential source of false negatives and inaccurate health risk assessments, J Pharm Biomed Anal 89, 158-65, 2014.
  • Qureshi ZP, Norris L, Sartor O, McKoy JM, Armstrong J, Raisch DW, Garg V, Stafkey-Mailey D, Bennett CL, Caveat oncologist: clinical findings and consequenc- es of distributing counterfeit erythropoietin in the United States, J Oncol Pract 8(2), 84-90, 2012.
  • Dalan R, Leow MK, George J, Chian KY, Tan A, Han HW, Cheow SP, Neuroglyco- penia and adrenergic responses to hypoglycaemia: insights from a local epidemic of serendipitous massive overdose of glibenclamide, Diabet Med 26(1), 105-9, 2009.
  • Bate R, Jensen P, Hess K, Mooney L, Milligan J. Substandard and falsified anti-tu- berculosis drugs: a preliminary field analysis. Int J Tuberc Lung Dis. Mar; 17(3): 308-11, 2013.
  • Ahmad K, Antidepressants are sold as antiretrovirals in DR Congo, Lancet 363(9410), 713, 2004.
  • Solomon S. Metal toxicity from counterfeit pills reinforces danger of internet meds. National Review of Medicine, 4(13), 2007. Available at: http://www.nationalrevie- wofmedicine.com/issue/2007/07_30/4_policy_politics_13.html
  • Wang F, Yu S, Liu K, Chen FE, Song Z, Zhang X, Xu X, Sun X, Acute intraocular inflammation caused by endotoxin after intravitreal injection of counterfeit bevaci- zumab in Shanghai, China. Ophthalmology 120(2), 355-61, 2013.
  • Alabdalla MA, Chemical characterization of counterfeit captagon tablets seized in Jordan, Forensic Sci Int 152(2-3), 185-8, 2005.
  • Venhuis BJ, Zomer G, Vredenbregt MJ, de Kaste D. The identification of (-)-trans-tada- lafil, tadalafil, and sildenafil in counterfeit Cialis and the optical purity of tadalafil stereoisomers, J Pharm Biomed Anal 51(3), 723-7, 2010.
  • Wertheimer AI, Identifying and combating counterfeit drugs, Expert Rew Clin Phar- macol 1(3), 333-336, 2008.
  • Delepierre A, Gayot A, Carpentier A. Update on counterfeit antibiotics worldwide; public health risks, Med Mal Infect 42(6), 247-55, 2012.
  • Newton PN, Green MD, Fernández FM, Day NP, White NJ. Counterfeit anti-infec- tive drugs. Lancet Infect Dis 6(9), 602-13, 2006.
  • Pharmacovigilance. Available at: http://www.who-umc.org/DynPage.aspx- ?id=97218&mn1=7347&mn2=7252 Accessed date: 24 Jan 2014.
  • İlaç Takip Sistemi. Available at: http://itsportal.saglik.gov.tr/ Accessed date: 4 Jan 2014.
  • Habertürk Daily News. Sahte ilaç operasyonu: Ünlü markalara ait çok sayıda sahte ilaç ele geçirildi. Available at: http://www.haberturk.com/gundem/haber/802220-sahte-il- ac-operasyonuAccessed date: 24 Jan 2014.
  • Habertürk Daily News. Eczacılardan internet isyanı. Available at: http://www.haber- turk.com/saglik/haber/800929-eczacilardan-internet-isyani Accessed date: 24 Jan 2014.
  • Sencan N, Counterfeiting in other industries: Lessons for pharmaceuticals, In: Coun- terfeit medicines, Ed(s): IA Wertheimer, PG Wang, pp 89-109, ILM Publications, UK, 2012.

Adverse effects of counterfeit drugs on public health

Year 2014, Volume: 44 Issue: 1, 89 - 99, 29.01.2015

Abstract

References

  • WHO, World Health Organization. General information on counterfeit medicines. Available at: http://www.who.int/medicines/services/counterfeit/overview/enAc- cessed date: 18 Dec 2013.
  • Editorial, Strengthening global action against poor quality drugs, Lancet 381(9867), 599, 2013.
  • EAASM 2008, The Counterfeiting Superhighway, Available at: http://www.eaasm.eu/ cache/downloads/dqqt3sge9hwssgcgcos440g40/455_EAASM_counterfeiting%20 report_020608(1).pdfAccessed date: 16 Jan 2014.
  • WHO 2010, Global status report on noncommunicable diseases, Available at: http:// www.who.int/nmh/publications/ncd_report_full_en.pdf. Accessed date: 16 Jan 2014.
  • Kozma CM, Reeder CE, Schulz RM, Economic, clinical, and humanistic outcomes: a planning model for pharmacoeconomic research, Clin Ther 15(6), 1121-32, 1993.
  • Oy B, Fake and Counterfeit Drug: A review, Afrimedic Journal 3(2), 1-4, 2012.
  • Bate R, Hess, Assessing Website Pharmacy Drug Quality: safer than You Think, PLoS One, 5(8), e12199, 2010.
  • Dean J, Klep R, Aquilina JW. Counterfeit dapoxetine sold on the Internet contains undis- closed sildenafil, Int J Clin Pract 64(9), 1319-22, 2010.
  • Chaubey SK, Sangla KS, Suthaharan EN, Tan YM. Severe hypoglycaemia associated with ingesting counterfeit medication, Med J, 192(12), 716-7, 2010.
  • Soltaninejad K, Faryadi M, Akhgari M, Bahmanabadi L. Chemical profile of counter- feit buprenorphine vials seized in Tehran, Iran. Forensic Sci Int 172(2-3), e4-5, 2007.
  • Hürriyet Daily News, Çete 30 ilacın sahtesini Türkiye’de yapıp dünyaya yaydı. Available at: http://www.hurriyet.com.tr/ekonomi/25337903.aspAccessed date: 14 Dec 2013.
  • Nair A, Strauch S, Lauwo J, Jähnke RW, Dressman J, Are counterfeit or substandard anti-infective products the cause of treatment failure in Papua New Guinea? J Pharm Sci 100(11), 5059-68, 2011.
  • Ortiz RS, Mariotti Kde C, Holzschuh MH, Romão W, Limberger RP, Mayorga P, Pro- filing counterfeit Cialis, Viagra and analogs by UPLC-MS, Forensic Sci Int 229(1-3), 13-20, 2013.
  • Venhuis BJ, Zwaagstra ME, Keizers PH, de Kaste D, Dose-to-dose variations with single packages of counterfeit medicines and adulterated dietary supplements as a potential source of false negatives and inaccurate health risk assessments, J Pharm Biomed Anal 89, 158-65, 2014.
  • Qureshi ZP, Norris L, Sartor O, McKoy JM, Armstrong J, Raisch DW, Garg V, Stafkey-Mailey D, Bennett CL, Caveat oncologist: clinical findings and consequenc- es of distributing counterfeit erythropoietin in the United States, J Oncol Pract 8(2), 84-90, 2012.
  • Dalan R, Leow MK, George J, Chian KY, Tan A, Han HW, Cheow SP, Neuroglyco- penia and adrenergic responses to hypoglycaemia: insights from a local epidemic of serendipitous massive overdose of glibenclamide, Diabet Med 26(1), 105-9, 2009.
  • Bate R, Jensen P, Hess K, Mooney L, Milligan J. Substandard and falsified anti-tu- berculosis drugs: a preliminary field analysis. Int J Tuberc Lung Dis. Mar; 17(3): 308-11, 2013.
  • Ahmad K, Antidepressants are sold as antiretrovirals in DR Congo, Lancet 363(9410), 713, 2004.
  • Solomon S. Metal toxicity from counterfeit pills reinforces danger of internet meds. National Review of Medicine, 4(13), 2007. Available at: http://www.nationalrevie- wofmedicine.com/issue/2007/07_30/4_policy_politics_13.html
  • Wang F, Yu S, Liu K, Chen FE, Song Z, Zhang X, Xu X, Sun X, Acute intraocular inflammation caused by endotoxin after intravitreal injection of counterfeit bevaci- zumab in Shanghai, China. Ophthalmology 120(2), 355-61, 2013.
  • Alabdalla MA, Chemical characterization of counterfeit captagon tablets seized in Jordan, Forensic Sci Int 152(2-3), 185-8, 2005.
  • Venhuis BJ, Zomer G, Vredenbregt MJ, de Kaste D. The identification of (-)-trans-tada- lafil, tadalafil, and sildenafil in counterfeit Cialis and the optical purity of tadalafil stereoisomers, J Pharm Biomed Anal 51(3), 723-7, 2010.
  • Wertheimer AI, Identifying and combating counterfeit drugs, Expert Rew Clin Phar- macol 1(3), 333-336, 2008.
  • Delepierre A, Gayot A, Carpentier A. Update on counterfeit antibiotics worldwide; public health risks, Med Mal Infect 42(6), 247-55, 2012.
  • Newton PN, Green MD, Fernández FM, Day NP, White NJ. Counterfeit anti-infec- tive drugs. Lancet Infect Dis 6(9), 602-13, 2006.
  • Pharmacovigilance. Available at: http://www.who-umc.org/DynPage.aspx- ?id=97218&mn1=7347&mn2=7252 Accessed date: 24 Jan 2014.
  • İlaç Takip Sistemi. Available at: http://itsportal.saglik.gov.tr/ Accessed date: 4 Jan 2014.
  • Habertürk Daily News. Sahte ilaç operasyonu: Ünlü markalara ait çok sayıda sahte ilaç ele geçirildi. Available at: http://www.haberturk.com/gundem/haber/802220-sahte-il- ac-operasyonuAccessed date: 24 Jan 2014.
  • Habertürk Daily News. Eczacılardan internet isyanı. Available at: http://www.haber- turk.com/saglik/haber/800929-eczacilardan-internet-isyani Accessed date: 24 Jan 2014.
  • Sencan N, Counterfeiting in other industries: Lessons for pharmaceuticals, In: Coun- terfeit medicines, Ed(s): IA Wertheimer, PG Wang, pp 89-109, ILM Publications, UK, 2012.
There are 30 citations in total.

Details

Primary Language English
Subjects Pharmacology and Pharmaceutical Sciences
Journal Section Makaleler
Authors

Hande Sipahi This is me

Kübra Peltekoglu This is me

Nazlı Şencan

Publication Date January 29, 2015
Published in Issue Year 2014 Volume: 44 Issue: 1

Cite

APA Sipahi, H., Peltekoglu, K., & Şencan, N. (2015). Adverse effects of counterfeit drugs on public health. Journal of Faculty of Pharmacy of Istanbul University, 44(1), 89-99.
AMA Sipahi H, Peltekoglu K, Şencan N. Adverse effects of counterfeit drugs on public health. Journal of Faculty of Pharmacy of Istanbul University. January 2015;44(1):89-99.
Chicago Sipahi, Hande, Kübra Peltekoglu, and Nazlı Şencan. “Adverse Effects of Counterfeit Drugs on Public Health”. Journal of Faculty of Pharmacy of Istanbul University 44, no. 1 (January 2015): 89-99.
EndNote Sipahi H, Peltekoglu K, Şencan N (January 1, 2015) Adverse effects of counterfeit drugs on public health. Journal of Faculty of Pharmacy of Istanbul University 44 1 89–99.
IEEE H. Sipahi, K. Peltekoglu, and N. Şencan, “Adverse effects of counterfeit drugs on public health”, Journal of Faculty of Pharmacy of Istanbul University, vol. 44, no. 1, pp. 89–99, 2015.
ISNAD Sipahi, Hande et al. “Adverse Effects of Counterfeit Drugs on Public Health”. Journal of Faculty of Pharmacy of Istanbul University 44/1 (January 2015), 89-99.
JAMA Sipahi H, Peltekoglu K, Şencan N. Adverse effects of counterfeit drugs on public health. Journal of Faculty of Pharmacy of Istanbul University. 2015;44:89–99.
MLA Sipahi, Hande et al. “Adverse Effects of Counterfeit Drugs on Public Health”. Journal of Faculty of Pharmacy of Istanbul University, vol. 44, no. 1, 2015, pp. 89-99.
Vancouver Sipahi H, Peltekoglu K, Şencan N. Adverse effects of counterfeit drugs on public health. Journal of Faculty of Pharmacy of Istanbul University. 2015;44(1):89-9.