ANTIMUSCARINIC EFFECTS OF AMITRIPTYLINE HCI AND OPIPRAMOLE HCI IN RAT ILEUM AND RAT DUODENUM

Year 1998, Volume: 32 , 43 - 50, 09.09.2015

S. Aydin O. Özdemir

Abstract

Arnitriptyline, a tricyclic antidepressant which is mainly used for major
depression treatment, was investigated about its antimuscarinic effects and as a
result it was found generally non-selective and 100 fold less active than atropine
(1,2,3,4). There are no satisfactory information about opipramole's antirnuscarinic
activity and selectivity.
Experiments were based on measuring agonist and antagonist responses in
isolated tissues in physiological conditions.

Key words: Antimuscarinic activity, Tricyclic antidepressants, Arnitriptyline,
Opipramole.

Keywords

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ANTIMUSCARINIC EFFECTS OF AMITRIPTYLINE HCI AND OPIPRAMOLE HCI IN RAT ILEUM AND RAT DUODENUM

Abstract

Arnitriptyline, a tricyclic antidepressant which is mainly used for major
depression treatment, was investigated about its antimuscarinic effects and as a
result it was found generally non-selective and 100 fold less active than atropine (1,2,3,4). There are no satisfactory information about opipramole's antirnuscarinic activity and selectivity.
Experiments were based on measuring agonist and antagonist responses in
isolated tissues in physiological conditions.

Keywords

Antimuscarinic activity, Tricyclic antidepressant, Arnitriptyline, Opipramole

References

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