Abstract
Amantadine HCl antiviral ve antiparkinson etkili bir ilagtlr. Bu Gahgmada amantadine HCl in 1,2-naftokinon-4-sulfonik asit sodyum tuzu ile olugturduii;~ tiirev yardlrm ile spektrofotometrik milstar tayini geligtirilmigtir. Reaksiyon sulu ortamda, pH 10 da, 60 "C da ve 30 dakilsada tamamlanmaktaclr. Olugan tiirevin maksimum absorpsiyonu 451 nrn'de gozlenmigtir. 0lqu egrisi 5-25 pglrnl araslnda do$jrusaldlr. Geligtirilen yontem amantadin HC1 ic;eren kapsullere uygulm~ ve sonuglar USP XXIII yonterni ile istatistik olarak hyaslmgtlr.
References
- 1. Bklanger, P.M., Grech-BClanger, O., J.Chron~atogr., 228,327 (1982).
- 3. Van-der-Horst, F.A.L., Teeuwsen, J., Holthuis, J.J.M., Brinkman,U.A.T., J. Pharnz. Biomed. Anal., 8,799 (1990).
- 4. Fujino, H., Goya, S., Clzenz.Pham.Brcll., 38,544 (1990).
- 5. Narassimhachari, N., Helgeson, E., Parakash, U., Chronzatographia, 12,523 (1979).
- 6. Tsuboushi, S., Gorornaru, T., Iguchi, S., .Iapar~ Alzalyst., 19,95 (1970).
- 7. Sinsheimer, J.E., Hong, D.D., Stewart, J.T., Fink, M.L., Burckhalter, J.H., J.Pharn~.Sci., 60, 141 (1971).
- 8. Silva, J.A.F., Strojny ,N., Ailal.Chenz., 47,714 (1975).
- 9. Harmon, R.E., Phipps, L.M., Howell, J.A., Gupta, S.K., Tetrahedroll, 25,5807 (1969).
- 10. Arnal, H., Giirsoy, A., Kreutzberger, A., J.Fac.Pkarnz. ista~zbul, 12,8 (1976).
- 11. Ozkmrnh, S., Sevingil, M., Acta Pharm.Tr~rc., 31,77 (1989).
- 12. Job, P., Aizrz.Chinz., 9, 1 13 (1928).
- 13. The United States Pharmacopeia XXIII, p. 73 United States Pharmacopeial Convention Inc. Rockville (1995).
Abstract
Amantadine HCl is used as an antiviral and an antiparkinson drug. We described spectrophotometric determination of amantadine HCl by derivatization
with sodium 1,2-naphtoquinone-4-sulfonate in aqueous medium. The structure
of the derivative was determined by IR, HI-NMR and mass spectral methods.
The derivative was obtained quantitatively at pH 10 and 60 "C in 30 minutes
and showed maximum absorption at 451 nm. The calibration curve obeys
Beers's Law in the 5-25 pg/ml range. The proposed method was applied to the
determination of amantadine HCl in pharmaceutical dosage form (capsule). The
results were statistically compared with USP XXIII procedure.
References
- 1. Bklanger, P.M., Grech-BClanger, O., J.Chron~atogr., 228,327 (1982).
- 3. Van-der-Horst, F.A.L., Teeuwsen, J., Holthuis, J.J.M., Brinkman,U.A.T., J. Pharnz. Biomed. Anal., 8,799 (1990).
- 4. Fujino, H., Goya, S., Clzenz.Pham.Brcll., 38,544 (1990).
- 5. Narassimhachari, N., Helgeson, E., Parakash, U., Chronzatographia, 12,523 (1979).
- 6. Tsuboushi, S., Gorornaru, T., Iguchi, S., .Iapar~ Alzalyst., 19,95 (1970).
- 7. Sinsheimer, J.E., Hong, D.D., Stewart, J.T., Fink, M.L., Burckhalter, J.H., J.Pharn~.Sci., 60, 141 (1971).
- 8. Silva, J.A.F., Strojny ,N., Ailal.Chenz., 47,714 (1975).
- 9. Harmon, R.E., Phipps, L.M., Howell, J.A., Gupta, S.K., Tetrahedroll, 25,5807 (1969).
- 10. Arnal, H., Giirsoy, A., Kreutzberger, A., J.Fac.Pkarnz. ista~zbul, 12,8 (1976).
- 11. Ozkmrnh, S., Sevingil, M., Acta Pharm.Tr~rc., 31,77 (1989).
- 12. Job, P., Aizrz.Chinz., 9, 1 13 (1928).
- 13. The United States Pharmacopeia XXIII, p. 73 United States Pharmacopeial Convention Inc. Rockville (1995).
Details
| Primary Language | English |
|---|---|
| Subjects | Pharmacology and Pharmaceutical Sciences |
| Journal Section | Makaleler |
| Authors | |
| Publication Date | September 9, 2015 |
| Published in Issue | Year 1998 Volume: 32 |