Formulation, development and evaluation of an osmotic drug delivery system for lornoxicam

Year 2023, , 10 - 21, 28.04.2023

Shoaeb Mohammad Syed , Iftequar Ahmed Syed Rajendra Panditrao Marathe

https://doi.org/10.26650/IstanbulJPharm.2023.1058131

Abstract

Background and Aims: The current study aimed to develop an osmotic drug delivery system for Lornoxicam to prolong its release.
Methods: Two different approaches were used for development of the osmotic drug delivery system; the first one was to for- mulate a controlled porosity osmotic tablet and the other was to design an elementary osmotic tablet. The controlled porosity osmotic tablets were coated with different concentrations of osmogents, a pore former, and varying coating thicknesses, and the effects were observed on the release. In the elementary osmotic pump, the tablets were drilled to make an orifice that creates pressure to release the drug by osmosis, and drug release was studied.
Results: The formulations were evaluated for different parameters namely appearance, uniformity of weight, drug content, hardness, and drug release. Also, the effect of different osmotic agents responsible for developing the osmotic pressure such as sodium chloride and mannitol along with the different concentrations of pore-forming sorbitol were studied. A compari- son was made between the controlled porosity osmotic tablet in which the membrane coating contains water-soluble pore- forming polymers that leach when the membrane comes in contact with water thereby permitting water inside the wall and creating the osmotic pressure to release the drug, and the elementary osmotic tablet containing the osmotic agent sodium chloride coated with the rate-controlling semipermeable membrane, cellulose acetate, which contains an orifice of a critical size through which the drug is delivered.
Conclusion: From the results, it was found that the developed formulation of the controlled porosity osmotic tablet was able to release Lornoxicam (CPOP) over 12 hours at zero-order kinetics and, the concentration of the osmotic agent, level of pore former, and thickness of the membrane coating are responsible for controlling the release of lornoxicam. The membrane coating was subjected to SEM analysis, which showed the formation of pores in the membrane. The developed controlled porosity osmotic pump tablet of lornoxicam was found to control the drug release for 12 hours.

Keywords

Lornoxicam, Controlled porosity osmotic tablet, Elementary osmotic tablet, Drug Release, Osmotic agents, Pore former & Scanning Electron Microscopy

Supporting Institution

NA

Project Number

NA

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