Cochleate Novel Drug Delivery System

Year 2025, Volume: 55 Issue: 3, 511 - 518, 14.01.2026

Ünnügülsüm Erdoğan , Yıldız Özsoy

https://doi.org/10.26650/IstanbulJPharm.2025.1531344

https://izlik.org/JA32FA73EK

Abstract

In contemporary times, novel drug delivery systems play a crucial role in facilitating the effective and safe transportation of drugs to their target sites, thus holding significant importance in research. Many active pharmaceutical ingredients suffer from low oral bioavailability because of their poor solubility in water and challenges in traversing biological membranes. To enhance therapeutic efficacy and mitigate side effects in formulations of such drugs with low oral bioavailability, numerous drug delivery systems have been developed. The most commonly elucidated systems are micelles, liposomes, dendrimers, nanocapsules, and nanospheres. Lipid-based drug delivery systems are pivotal platforms that facilitate the transport of drugs to target tissues, enhance solubility, and improve bioavailability. These systems leverage the inherent properties of lipids to facilitate drug transport. Notably, cochleates are lipidic structures that deserve particular attention within these systems. Cochleates are spiral structures formed as a result of the interaction of calcium ions with negatively charged phospholipids. These lipidic structures play a significant role in drug transport by protecting, stabilising, and facilitating the delivery of drugs to the intended tissue.

This review discusses various aspects of cochleate, including their structure, formation, preparation, utilisation as drug carriers, impact on bioavailability, and future potential. Additionally, the current status and future prospects of cochleate will be evaluated.

This study provides a comprehensive overview of the advantages and potential applications of cochleate in drug delivery.

Keywords

Drug Delivery Systems , Cochleate , Bioavailability

References

• Ağardan, N. B. M., Değim, Z., Yılmaz, Ş., Altıntaş, L., & Topal, T. (2016). The effectiveness of raloxifene-loaded liposomes and cochleates in breast cancer therapy. AAPS Pharm Sci Tech, 17, 968-977. google scholar
• Ahiwale, R. J., Chellampillai, B., & Pawar, A. P. (2022). Investigation of novel sorafenib tosylate loaded biomaterial based nano-cochleates dispersion system for treatment of hepatocellular carcinoma. Journal of Dispersion Science And Technology, 43(10), 1568-1586. google scholar
• Asprea, M., Tatini, F., Piazzini, V., Rossi, F., Bergonzi, M. C., & Bilia, A. R. (2019). Stable, monodisperse, and highly cell-permeating nanocochleates from natural soy lecithin liposomes. Pharmaceutics, 11(1), 34. google scholar
• Batista-Duharte, A., Lastre, M., Romeu, B., Portuondo, D. L., Téllez-Martínez, D., Manente, F. A., … & Carlos, I. Z. (2016). Antifungal and immunomodulatory activity of a novel cochleate for amphotericin B delivery against Sporothrix schenckii. International Immunopharmacology, 40, 277-287. google scholar
• Bothiraja, C., Rajput, N., Poudel, I., Rajalakshmi, S., Panda, B., & Pawar, A. (2018). Development of novel biofunctionalized chitosan decorated nanocochleates as a cancer targeted drug delivery platform. Artificial Cells, Nanomedicine, and Biotechnology, 46(sup1), 447-461. google scholar
• Bothiraja, C., Yojana, B. D., Pawar, A. P., Shaikh, K. S., & Thorat, U. H. (2014). Fisetin-loaded nanocochleates: formulation, characterisation, in vitro anticancer testing, bioavailability and biodistribution study. Expert Opinion On Drug Delivery, 11(1), 17-29. google scholar
• Bozó, T., Wacha, A., Mihály, J., Bóta, A., & Kellermayer, M. S. (2017). Dispersion and stabilization of cochleate nanoparticles. European Journal Of Pharmaceutics And Biopharmaceutics, 117, 270-275. google scholar
• Castro, A. L., Pomel, S., Cailleau, C., Fournier, N., Dennemont, I., Loiseau, P. M., & Barratt, G. (2022). Pharmacokinetics, biodistribution, and activity of amphotericin B-loaded nanocochleates on the Leishmania donovani murine visceral leishmaniasis model. International Journal Of Pharmaceutics, 624, 121985. google scholar
• Farasati Far, B., Naimi-Jamal, M. R., Sedaghat, M., Hoseini, A., Mohammadi, N., & Bodaghi, M. (2023). Combinational system of lipid-based nanocarriers and biodegradable polymers for wound healing: an updated review. Journal Of Functional Biomaterials, 14(2), 115. google scholar
• Ghauri, A., Ghauri, I., Elhissi, A. M., & Ahmed, W. (2020). Characterization of cochleate nanoparticles for delivery of the anti-asthma drug beclomethasone dipropionate. In Advances In Medical And Surgical Engineering (pp. 267-277). Academic Press. google scholar
• google scholar
• Gonçalves, A., Estevinho, B. N., & Rocha, F. (2016). Microencapsulation of vitamin A: A review. Trends In Food Science & Technology, 51, 76-87. google scholar
• Hollander, A., & Danino, D. (2015). Cochleate characterization by cryogenic electron microscopy methods: Cryo-TEM and Cryo-SEM. Colloids and Surfaces A: Physicochemical And Engineering Aspects, 483, 187-192. google scholar
• Judeh, Z. (2019). Alginate-coating of artemisinin-loaded cochleates results in better control over gastro-intestinal release for effective oral delivery. Journal Of Drug Delivery Science And Technology, 52, 27-36. google scholar
• Judeh, Z. (2021). Insights into the mechanism of formation of non-conventional cochleates and its impact on their functional properties. Journal Of Molecular Liquids, 335, 116249. google scholar
• Kristensen, S., Hassan, K., Andersen, N. S., Steiniger, F., & Kuntsche, J. (2023). Feasibility of the preparation of cochleate suspensions from naturally derived phosphatidylserines. Frontiers In Medical Technology, 5, 1241368. google scholar
• Landge, A., Pawar, A.., & Shaikh, K. (2013). Investigation of cochleates as carriers for topical drug delivery. Int. J. Pharm. Pharm. Sci, 5(2), 314-320. google scholar
• Lee, J., Goo, Y. T., Shakhakarmi, K., Kang, M. J., & Lee, S. (2025). Exploring the promises and challenges of cochleates for drug delivery applications. Journal of Pharmaceutical Investigation, 1-17. google scholar
• Lipa-Castro, A., Legrand, F. X., & Barratt, G. (2021). Cochleate drug delivery systems: An approach to their characterization. International Journal Of Pharmaceutics, 610, 121225. google scholar
• Mulrajani, K., Rajnani, N., & Kurup, N. (2023). Nanocochleates and Drug-Phospholipid Complex: Novel Approaches for Phospholipid Based Oral Delivery of Anti-Cancer Agents. Indian Journal Of Pharmaceutical Sciences, 85(1). google scholar
• Nagarsekar, K., Ashtikar, M., Steiniger, F., Thamm, J., Schacher, F. H., & Fahr, A. (2017). Micro-spherical cochleate composites: Method development for monodispersed cochleate system. Journal Of Liposome Research, 27(1), 32-40. google scholar
• Nagarsekar, K., Ashtikar, M., Steiniger, F., Thamm, J., Schacher, F., & Fahr, A. (2016). Understanding cochleate formation: insights into structural development. Soft Matter, 12(16), 3797-3809. google scholar
• Nayek, S., Venkatachalam, A., & Choudhury, S. (2019). Recent nanocochleate drug delivery system for cancer treatment: a review. International Journal Of Current Pharmaceutical Research, 28-32. google scholar
• Pawar, A. P., Vinugala, D., & Bothiraja, C. (2014). Nanocochleates derived from nanoliposomes for paclitaxel oral use: preparation, characterization, in vitro anticancer testing, bioavailability and biodistribution study in rats. Biomed Pharmacother, 3502, 1-9. google scholar
• Pawar, A., Bothiraja, C., Shaikh, K., & Mali, A. (2015). An insight into cochleates, a potential drug delivery system. RSC Advances, 5(99), 81188-81202. google scholar
• Ramasamy, T., Khandasamy, U., Hinabindhu, R. & Kona K. (2009). Nanocochleate—a new drug delivery system. FABAD Journal Of Pharmaceutical Sciences, 34, 91-101. google scholar
• Shanmugam, T., Joshi, N., Ahamad, N., Deshmukh, A., & Banerjee, R. (2020). Enhanced absorption, and efficacy of oral self-assembled paclitaxel nanocochleates in multi-drug resistant colon cancer. International Journal Of Pharmaceutics, 586, 119482. google scholar
• Shende, P., Khair, R., & Gaud, R. S. (2019). Nanostructured cochleates: A multi-layered platform for cellular transportation of therapeutics. Drug Development And Industrial Pharmacy, 45(6), 869-881. google scholar
• Tilawat, M., & Bonde, S. (2021). Nanocochleates: A potential drug delivery system. Journal Of Molecular Liquids, 334, 116115. google scholar
• Wang, N., Wang, T., Zhang, M., Chen, R., & Deng, Y. (2014). Using procedure of emulsification–lyophilization to form lipid A-incorporating cochleates as an effective oral mucosal vaccine adjuvant-delivery system (VADS). International Journal Of Pharmaceutics, 468(1-2), 39-49. google scholar
• Wong, P. W. K., & Judeh, Z. (2020). Continuous, high-throughput production of artemisinin-loaded supramolecular cochleates using simple off-the-shelf flow focusing device. Materials Science And Engineering: C, 108, 110410. google scholar
• Yadav V, Parab B and Shidhaye S (2021). Nanocochleate: a novel approach for delivery of biological molecules. Int J Pharm Sci & Res 2021; 12(7): 3581-92. doi: 10.13040/ IJPSR.0975-8232.12(7).3581-92. google scholar
• Yücel, Ç., & Değim, Z. (2019). Kohleatlar ve tedavideki etkinliği. Sağlık Bilimleri Dergisi: C, 28 (1). google scholar
• Zarif, L. (2005). Drug delivery by lipid cochleates. In Methods In Enzymology (Vol. 391, pp. 314-329). Academic Press. google scholar
• Zhang, X., Ma, Y., Shi, Y., Jiang, L., Wang, L., ur Rashid, H., … & Liu, X. (2024). Advances in liposomes loaded with photoresponse materials for cancer therapy. Biomedicine & Pharmacotherapy, 174, 116586 google scholar