Preparation and in vitro studies of fixed-dose tablet combination of repaglinide and metformin

Sinem Şahin; Burcu Mesut; M. Ezgi Durgun; Esher Özçelik; Yıldız Özsoy

Preparation and in vitro studies of fixed-dose tablet combination of repaglinide and metformin

Abstract

Background and Aims: The study aimed to design a Fixed-dose tablet formulation of Metformine and Repaglinide. Methods: Wet granulation method was used to prepare tablet formulations. Characterization studies and dissolution studies were performed. Results: A stable formulation was developed according to the requirements of the pharmacopoeia criteria. This new formulsation dissolution results showed that Repaglinide and Metformin HCl dissolved more than 85% from film tablets at 15 minutes. Conclusion: Thus, an alternative product to the market product was developed.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacology and Pharmaceutical Sciences, Health Care Administration

Journal Section

Research Article

Authors

Sinem Şahin This is me
0000-0002-0377-2757
Türkiye

Burcu Mesut This is me
0000-0003-2838-1688
Türkiye

M. Ezgi Durgun This is me
0000-0001-5724-9809
Türkiye

Esher Özçelik This is me
0000-0002-5611-1143
Türkiye

Yıldız Özsoy ^* This is me
0000-0002-9110-3704
Türkiye

Publication Date

April 30, 2021

Submission Date

July 13, 2020

Acceptance Date

October 14, 2020

Published in Issue

Year 2021 Volume: 51 Number: 1

IZ

https://izlik.org/JA66DL73EH

Cite

RIS / Bibtex

APA

Şahin, S., Mesut, B., Durgun, M. E., Özçelik, E., & Özsoy, Y. (2021). Preparation and in vitro studies of fixed-dose tablet combination of repaglinide and metformin. İstanbul Journal of Pharmacy, 51(1), 26-34. https://izlik.org/JA66DL73EH

AMA

1.Şahin S, Mesut B, Durgun ME, Özçelik E, Özsoy Y. Preparation and in vitro studies of fixed-dose tablet combination of repaglinide and metformin. iujp. 2021;51(1):26-34. https://izlik.org/JA66DL73EH

Chicago

Şahin, Sinem, Burcu Mesut, M. Ezgi Durgun, Esher Özçelik, and Yıldız Özsoy. 2021. “Preparation and in Vitro Studies of Fixed-Dose Tablet Combination of Repaglinide and Metformin”. İstanbul Journal of Pharmacy 51 (1): 26-34. https://izlik.org/JA66DL73EH.

EndNote

Şahin S, Mesut B, Durgun ME, Özçelik E, Özsoy Y (April 1, 2021) Preparation and in vitro studies of fixed-dose tablet combination of repaglinide and metformin. İstanbul Journal of Pharmacy 51 1 26–34.

IEEE

[1]S. Şahin, B. Mesut, M. E. Durgun, E. Özçelik, and Y. Özsoy, “Preparation and in vitro studies of fixed-dose tablet combination of repaglinide and metformin”, iujp, vol. 51, no. 1, pp. 26–34, Apr. 2021, [Online]. Available: https://izlik.org/JA66DL73EH

ISNAD

Şahin, Sinem - Mesut, Burcu - Durgun, M. Ezgi - Özçelik, Esher - Özsoy, Yıldız. “Preparation and in Vitro Studies of Fixed-Dose Tablet Combination of Repaglinide and Metformin”. İstanbul Journal of Pharmacy 51/1 (April 1, 2021): 26-34. https://izlik.org/JA66DL73EH.

JAMA

1.Şahin S, Mesut B, Durgun ME, Özçelik E, Özsoy Y. Preparation and in vitro studies of fixed-dose tablet combination of repaglinide and metformin. iujp. 2021;51:26–34.

MLA

Şahin, Sinem, et al. “Preparation and in Vitro Studies of Fixed-Dose Tablet Combination of Repaglinide and Metformin”. İstanbul Journal of Pharmacy, vol. 51, no. 1, Apr. 2021, pp. 26-34, https://izlik.org/JA66DL73EH.

Vancouver

1.Sinem Şahin, Burcu Mesut, M. Ezgi Durgun, Esher Özçelik, Yıldız Özsoy. Preparation and in vitro studies of fixed-dose tablet combination of repaglinide and metformin. iujp [Internet]. 2021 Apr. 1;51(1):26-34. Available from: https://izlik.org/JA66DL73EH