The formulation and characterization of water-soluble snakehead fish (Ophiocephalus striatus) dry extract in nanoemulsion using permeation and in vivo study

Robert Tungadi; Widysusanti Abdulkadir; Munafri Tahir

The formulation and characterization of water-soluble snakehead fish (Ophiocephalus striatus) dry extract in nanoemulsion using permeation and in vivo study

Abstract

Background and Aims: The study was conducted to determine the optimal concentration of water-soluble snakehead fish dry extract (SFDE) in nanoemulsion and the amount of albumin required to penetrate the skin in order to accelerate the wound healing process. Methods: The snakehead fish (SF) was extracted using an atomizer while the nanoemulsion basis was optimized using oleic acid, Tween 80, and propylene glycol. The developed SFDE in nanoemulsion was characterized based on droplet size, PDI, and zeta potential. The ability of the mixture to penetrate the snakeskin was tested using Franz diffusion cells. The effectiveness of the nanoemulsion was evaluated by dividing the rabbits used for experiment into 6 treatment groups including SFDE F1 0.25%, F2 0.5%, F3 1%, F4 SF 2% cream, F5 nanoemulsion basis, and F6 no treatment. Results: The SFDE nanoemulsion produced a particle size of 147.5 nm with acceptable PDI (0.23) and zeta potential (+13.38 mV). The most effective SFDE to accelerate the healing of open wounds in rabbits was a concentration of 1%, which was found to have dried and closed the wound on the 3rd day. Conclusion: The permeation study and the effectiveness test showed the 1% SFDE nanoemulsion is the best concentration in accelerating the wound healing process and ensuring the highest albumin penetration into the skin.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacology and Pharmaceutical Sciences, Health Care Administration

Journal Section

Research Article

Authors

Robert Tungadi ^* This is me
0000-0003-2141-2402
Indonesia

Widysusanti Abdulkadir This is me
0000-0002-8975-134X
Indonesia

Munafri Tahir This is me
0000-0002-9351-2843
Indonesia

Publication Date

April 30, 2021

Submission Date

May 10, 2020

Acceptance Date

September 21, 2020

Published in Issue

Year 2021 Volume: 51 Number: 1

IZ

https://izlik.org/JA52GZ87WL

Cite

RIS / Bibtex

APA

Tungadi, R., Abdulkadir, W., & Tahir, M. (2021). The formulation and characterization of water-soluble snakehead fish (Ophiocephalus striatus) dry extract in nanoemulsion using permeation and in vivo study. İstanbul Journal of Pharmacy, 51(1), 35-41. https://izlik.org/JA52GZ87WL

AMA

1.Tungadi R, Abdulkadir W, Tahir M. The formulation and characterization of water-soluble snakehead fish (Ophiocephalus striatus) dry extract in nanoemulsion using permeation and in vivo study. iujp. 2021;51(1):35-41. https://izlik.org/JA52GZ87WL

Chicago

Tungadi, Robert, Widysusanti Abdulkadir, and Munafri Tahir. 2021. “The Formulation and Characterization of Water-Soluble Snakehead Fish (Ophiocephalus Striatus) Dry Extract in Nanoemulsion Using Permeation and in Vivo Study”. İstanbul Journal of Pharmacy 51 (1): 35-41. https://izlik.org/JA52GZ87WL.

EndNote

Tungadi R, Abdulkadir W, Tahir M (April 1, 2021) The formulation and characterization of water-soluble snakehead fish (Ophiocephalus striatus) dry extract in nanoemulsion using permeation and in vivo study. İstanbul Journal of Pharmacy 51 1 35–41.

IEEE

[1]R. Tungadi, W. Abdulkadir, and M. Tahir, “The formulation and characterization of water-soluble snakehead fish (Ophiocephalus striatus) dry extract in nanoemulsion using permeation and in vivo study”, iujp, vol. 51, no. 1, pp. 35–41, Apr. 2021, [Online]. Available: https://izlik.org/JA52GZ87WL

ISNAD

Tungadi, Robert - Abdulkadir, Widysusanti - Tahir, Munafri. “The Formulation and Characterization of Water-Soluble Snakehead Fish (Ophiocephalus Striatus) Dry Extract in Nanoemulsion Using Permeation and in Vivo Study”. İstanbul Journal of Pharmacy 51/1 (April 1, 2021): 35-41. https://izlik.org/JA52GZ87WL.

JAMA

1.Tungadi R, Abdulkadir W, Tahir M. The formulation and characterization of water-soluble snakehead fish (Ophiocephalus striatus) dry extract in nanoemulsion using permeation and in vivo study. iujp. 2021;51:35–41.

MLA

Tungadi, Robert, et al. “The Formulation and Characterization of Water-Soluble Snakehead Fish (Ophiocephalus Striatus) Dry Extract in Nanoemulsion Using Permeation and in Vivo Study”. İstanbul Journal of Pharmacy, vol. 51, no. 1, Apr. 2021, pp. 35-41, https://izlik.org/JA52GZ87WL.

Vancouver

1.Robert Tungadi, Widysusanti Abdulkadir, Munafri Tahir. The formulation and characterization of water-soluble snakehead fish (Ophiocephalus striatus) dry extract in nanoemulsion using permeation and in vivo study. iujp [Internet]. 2021 Apr. 1;51(1):35-41. Available from: https://izlik.org/JA52GZ87WL