Rational design and synthesis of quinazoline derivatives

Fatimah Alkharaz; Zead Abudayeh; Qais Abualassal; Loay Hassouneh

Rational design and synthesis of quinazoline derivatives

Abstract

Background and Aims: Alzheimer's disease is a neurodegenerative disorder in which the death of brain cells causes memory loss and cognitive decline. It is one of the leading causes of mortality worldwide. Several different hallmarks of the disease have been reported such as low levels of acetylcholine, deposits of β-amyloid around neurons, hyperphosphorylated tau protein, oxidative stress, etc. Pharmacotherapy for this disease currently depends on using acetylcholinesterase inhibitors and N-methyl-D-aspartate receptor antagonists. They provide only symptomatic relief and mostly targets cognitive revival. Quinazoline derivatives were recently reported as being a valuable template in the treatment of many neurodegenerative disorders. Quinazoline based compounds were declared as being potential anti AD agents. This research focuses on the synthesis of novel quinazoline derivatives 3 and 4. Methods: Novel quinazoline derivatives 3 and 4 were synthesized starting from 2-(methylamino)benzamide by consecutive steps. The structures of these compounds have been characterized using different analytical and spectral methods: TLC, GC-MS, 1H-NMR and 13C-NMR. Results: This study revealed the synthesis of the novel compounds 3 and 4 with excellent yields equalling 97% and 73.1% respectively. Conclusion: Novel quinazoline derivatives compounds 3 and 4 were obtained. These compounds might be promising lead compounds for potential poly-functional anti-Alzheimer's agents in future work.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacology and Pharmaceutical Sciences, Health Care Administration

Journal Section

Research Article

Authors

Fatimah Alkharaz This is me
0000-0001-9198-0603
Jordan

Zead Abudayeh This is me
0000-0003-4879-5634
Jordan

Qais Abualassal This is me
0000-0002-6784-3147
Jordan

Loay Hassouneh This is me
0000-0002-8278-7278
Jordan

Publication Date

April 30, 2021

Submission Date

May 20, 2020

Acceptance Date

September 21, 2020

Published in Issue

Year 2021 Volume: 51 Number: 1

IZ

https://izlik.org/JA76KK95UF

Cite

RIS / Bibtex

APA

Alkharaz, F., Abudayeh, Z., Abualassal, Q., & Hassouneh, L. (2021). Rational design and synthesis of quinazoline derivatives. İstanbul Journal of Pharmacy, 51(1), 50-58. https://izlik.org/JA76KK95UF

AMA

1.Alkharaz F, Abudayeh Z, Abualassal Q, Hassouneh L. Rational design and synthesis of quinazoline derivatives. iujp. 2021;51(1):50-58. https://izlik.org/JA76KK95UF

Chicago

Alkharaz, Fatimah, Zead Abudayeh, Qais Abualassal, and Loay Hassouneh. 2021. “Rational Design and Synthesis of Quinazoline Derivatives”. İstanbul Journal of Pharmacy 51 (1): 50-58. https://izlik.org/JA76KK95UF.

EndNote

Alkharaz F, Abudayeh Z, Abualassal Q, Hassouneh L (April 1, 2021) Rational design and synthesis of quinazoline derivatives. İstanbul Journal of Pharmacy 51 1 50–58.

IEEE

[1]F. Alkharaz, Z. Abudayeh, Q. Abualassal, and L. Hassouneh, “Rational design and synthesis of quinazoline derivatives”, iujp, vol. 51, no. 1, pp. 50–58, Apr. 2021, [Online]. Available: https://izlik.org/JA76KK95UF

ISNAD

Alkharaz, Fatimah - Abudayeh, Zead - Abualassal, Qais - Hassouneh, Loay. “Rational Design and Synthesis of Quinazoline Derivatives”. İstanbul Journal of Pharmacy 51/1 (April 1, 2021): 50-58. https://izlik.org/JA76KK95UF.

JAMA

1.Alkharaz F, Abudayeh Z, Abualassal Q, Hassouneh L. Rational design and synthesis of quinazoline derivatives. iujp. 2021;51:50–58.

MLA

Alkharaz, Fatimah, et al. “Rational Design and Synthesis of Quinazoline Derivatives”. İstanbul Journal of Pharmacy, vol. 51, no. 1, Apr. 2021, pp. 50-58, https://izlik.org/JA76KK95UF.

Vancouver

1.Fatimah Alkharaz, Zead Abudayeh, Qais Abualassal, Loay Hassouneh. Rational design and synthesis of quinazoline derivatives. iujp [Internet]. 2021 Apr. 1;51(1):50-8. Available from: https://izlik.org/JA76KK95UF