The effects of vanadyl sulfate on glutathione, lipid peroxidation and nonenzymatic glycosylation levels in various tissues in experimental diabetes

Sevim Tunalı; Refiye Yanardağ

The effects of vanadyl sulfate on glutathione, lipid peroxidation and nonenzymatic glycosylation levels in various tissues in experimental diabetes

Abstract

Background and Aims: Diabetes mellitus is characterized by hyperglycemia which over time leads to serious damage of several body systems. Vanadium ions and their complexes have been demonstrated to have various insulin-mimetic and antidiabetic effects. The object of the present work was to investigate the effect of vanadyl sulfate (VS) on serum total lipid and protein parameters, glutathione, lipid peroxidation and nonenzymatic glycosylation levels in cardiac, lens, lung and skeletal muscle tissues of STZ diabetic rats. Methods: Randomly selected 6.0 - 6.5 month old Swiss Albino rats were separated into two diabetic and two control groups. A single intraperitoneal injection of 65 mg/kg streptozotocin (STZ) in 0.01 M citrate buffer (pH 4.5) was used to induce diabetes. 100 mg/kg VS was administered daily to one of the controls and one of the diabetic groups. On the 60th day of the experiment, serum total lipid and total protein levels were determined. Results: Tissue samples were taken and used for determination of glutathione (GSH), lipid peroxidation (LPO) and nonenzymatic glycosylation (GSH) and protein levels. Conclusion: According to the results, treatment with VS reversed the effects of diabetes by exerting antioxidant properties and preventing damage caused by diabetes on various tissues along with some serum parameters.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacology and Pharmaceutical Sciences, Health Care Administration

Journal Section

Research Article

Authors

Sevim Tunalı ^* This is me
0000-0003-3363-1290
Türkiye

Refiye Yanardağ This is me
0000-0003-4185-4363
Türkiye

Publication Date

April 30, 2021

Submission Date

April 10, 2020

Acceptance Date

July 3, 2020

Published in Issue

Year 2021 Volume: 51 Number: 1

IZ

https://izlik.org/JA57UN87DX

Cite

RIS / Bibtex

APA

Tunalı, S., & Yanardağ, R. (2021). The effects of vanadyl sulfate on glutathione, lipid peroxidation and nonenzymatic glycosylation levels in various tissues in experimental diabetes. İstanbul Journal of Pharmacy, 51(1), 73-78. https://izlik.org/JA57UN87DX

AMA

1.Tunalı S, Yanardağ R. The effects of vanadyl sulfate on glutathione, lipid peroxidation and nonenzymatic glycosylation levels in various tissues in experimental diabetes. iujp. 2021;51(1):73-78. https://izlik.org/JA57UN87DX

Chicago

Tunalı, Sevim, and Refiye Yanardağ. 2021. “The Effects of Vanadyl Sulfate on Glutathione, Lipid Peroxidation and Nonenzymatic Glycosylation Levels in Various Tissues in Experimental Diabetes”. İstanbul Journal of Pharmacy 51 (1): 73-78. https://izlik.org/JA57UN87DX.

EndNote

Tunalı S, Yanardağ R (April 1, 2021) The effects of vanadyl sulfate on glutathione, lipid peroxidation and nonenzymatic glycosylation levels in various tissues in experimental diabetes. İstanbul Journal of Pharmacy 51 1 73–78.

IEEE

[1]S. Tunalı and R. Yanardağ, “The effects of vanadyl sulfate on glutathione, lipid peroxidation and nonenzymatic glycosylation levels in various tissues in experimental diabetes”, iujp, vol. 51, no. 1, pp. 73–78, Apr. 2021, [Online]. Available: https://izlik.org/JA57UN87DX

ISNAD

Tunalı, Sevim - Yanardağ, Refiye. “The Effects of Vanadyl Sulfate on Glutathione, Lipid Peroxidation and Nonenzymatic Glycosylation Levels in Various Tissues in Experimental Diabetes”. İstanbul Journal of Pharmacy 51/1 (April 1, 2021): 73-78. https://izlik.org/JA57UN87DX.

JAMA

1.Tunalı S, Yanardağ R. The effects of vanadyl sulfate on glutathione, lipid peroxidation and nonenzymatic glycosylation levels in various tissues in experimental diabetes. iujp. 2021;51:73–78.

MLA

Tunalı, Sevim, and Refiye Yanardağ. “The Effects of Vanadyl Sulfate on Glutathione, Lipid Peroxidation and Nonenzymatic Glycosylation Levels in Various Tissues in Experimental Diabetes”. İstanbul Journal of Pharmacy, vol. 51, no. 1, Apr. 2021, pp. 73-78, https://izlik.org/JA57UN87DX.

Vancouver

1.Sevim Tunalı, Refiye Yanardağ. The effects of vanadyl sulfate on glutathione, lipid peroxidation and nonenzymatic glycosylation levels in various tissues in experimental diabetes. iujp [Internet]. 2021 Apr. 1;51(1):73-8. Available from: https://izlik.org/JA57UN87DX