Evaluation of toxic effects of statins and their possible role in treatment of cancer

Aysun Ökçesiz; Ülkü Ündeğer Bucurgat

Evaluation of toxic effects of statins and their possible role in treatment of cancer

Abstract

Hydroxymethyl glutaryl CoA (HMG-CoA) reductase inhibitors (statins) are drugs that show hypolipidemic effect via inhibition of hydroxymethyl glutaryl CoA reductase (HMG CoA R), a rate-limiting step in the synthesis of cholesterol. The effects of statins, independent of lipid-lowering ones , are termed pleiotropic effects and these have gained importance in recent years. Potential anticancer effect, one of the pleotropic effects of statins, is remarkable. In this review we aim to summarize the possible use of statins in the treatment of cancer. Pleiotropic effects include antioxidant and antiinflammatory activities due to inhibition of new vessel formation in cancer cells, reduction of resistance to chemotherapeutic agents and inhibition of the production of reactive oxygen species (ROS) with the induction of apoptosis. The potential anticancer activity of statins against different tumor models is emphasized in vitro and in vivo conditions. For this reason, current efforts are directed to providing therapeutic benefits from statins in the treatment of cancer. This study shows that statins can be effective in preclinical models in advanced or recurrent metastatic diseases when administered alone or in combination with molecularly targeted agents. Future studies may shed further light on this topic.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacology and Pharmaceutical Sciences, Health Care Administration

Journal Section

Review

Authors

Aysun Ökçesiz This is me
0000-0001-9130-2853
Türkiye

Ülkü Ündeğer Bucurgat ^* This is me
0000-0002-6692-0366
Türkiye

Publication Date

April 30, 2021

Submission Date

January 20, 2020

Acceptance Date

September 4, 2020

Published in Issue

Year 2021 Volume: 51 Number: 1

IZ

https://izlik.org/JA82CK93CM

Cite

RIS / Bibtex

APA

Ökçesiz, A., & Ündeğer Bucurgat, Ü. (2021). Evaluation of toxic effects of statins and their possible role in treatment of cancer. İstanbul Journal of Pharmacy, 51(1), 154-160. https://izlik.org/JA82CK93CM

AMA

1.Ökçesiz A, Ündeğer Bucurgat Ü. Evaluation of toxic effects of statins and their possible role in treatment of cancer. iujp. 2021;51(1):154-160. https://izlik.org/JA82CK93CM

Chicago

Ökçesiz, Aysun, and Ülkü Ündeğer Bucurgat. 2021. “Evaluation of Toxic Effects of Statins and Their Possible Role in Treatment of Cancer”. İstanbul Journal of Pharmacy 51 (1): 154-60. https://izlik.org/JA82CK93CM.

EndNote

Ökçesiz A, Ündeğer Bucurgat Ü (April 1, 2021) Evaluation of toxic effects of statins and their possible role in treatment of cancer. İstanbul Journal of Pharmacy 51 1 154–160.

IEEE

[1]A. Ökçesiz and Ü. Ündeğer Bucurgat, “Evaluation of toxic effects of statins and their possible role in treatment of cancer”, iujp, vol. 51, no. 1, pp. 154–160, Apr. 2021, [Online]. Available: https://izlik.org/JA82CK93CM

ISNAD

Ökçesiz, Aysun - Ündeğer Bucurgat, Ülkü. “Evaluation of Toxic Effects of Statins and Their Possible Role in Treatment of Cancer”. İstanbul Journal of Pharmacy 51/1 (April 1, 2021): 154-160. https://izlik.org/JA82CK93CM.

JAMA

1.Ökçesiz A, Ündeğer Bucurgat Ü. Evaluation of toxic effects of statins and their possible role in treatment of cancer. iujp. 2021;51:154–160.

MLA

Ökçesiz, Aysun, and Ülkü Ündeğer Bucurgat. “Evaluation of Toxic Effects of Statins and Their Possible Role in Treatment of Cancer”. İstanbul Journal of Pharmacy, vol. 51, no. 1, Apr. 2021, pp. 154-60, https://izlik.org/JA82CK93CM.

Vancouver

1.Aysun Ökçesiz, Ülkü Ündeğer Bucurgat. Evaluation of toxic effects of statins and their possible role in treatment of cancer. iujp [Internet]. 2021 Apr. 1;51(1):154-60. Available from: https://izlik.org/JA82CK93CM