Bioavailability of berberine: challenges and solutions

Asha Thomas; Seema Kamble; Sanjeevani Deshkar; Lata Kothapalli; Sohan Chitlange

Bioavailability of berberine: challenges and solutions

Abstract

Berberine is a quaternary benzylisoquinoline alkaloid with multiple pharmacological effects used for the treatment of hypertension, tumors, bacterial infections, inflammation, HIV, and cardiac diseases. In phase I clinical trials, berberine is safe at excessive doses but manifests poor bioavailability. Major challenges like poor absorption, rapid metabolism, and rapid systemic elimination are responsible for low plasma and tissue levels of berberine. Various strategies have been undertaken by several researchers to overcome this issue and enhance the bioavailability of berberine. This includes the design of new formulation strategies; novel drug delivery systems (NDDS) like liposomes, nanosized dosage forms, phospholipid complexes, mucoadhesive microparticles, and micoemulsions; the use of adjuvants; and the design of structural analogous of berberine. This review focuses on the occurrence of berberine in numerous plants and its pharmacological activities as evidenced through numerous preclinical and clinical studies. The later part of this review highlights the bioavailability issue of berberine which arises due to its poor absorption, elevated rate and extent of metabolism, and quick elimination and clearance from the body. A systematic effort has beenmade to analyze the various formulation strategies, including the design of newer berberine analogues and derivatives. These strategies can be further explored to increase the bioavailability, medicinal value, and application of this promising molecule.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacology and Pharmaceutical Sciences, Health Care Administration

Journal Section

Review

Authors

Asha Thomas ^* This is me
0000-0003-1058-8779
India

Seema Kamble This is me
0000-0003-0967-1225
India

Sanjeevani Deshkar This is me
0000-0002-3393-717X
India

Lata Kothapalli This is me
0000-0002-7412-5805
India

Sohan Chitlange This is me
0000-0002-9355-3303
India

Publication Date

April 30, 2021

Submission Date

July 3, 2020

Acceptance Date

November 18, 2020

Published in Issue

Year 2021 Volume: 51 Number: 1

IZ

https://izlik.org/JA68HB64EF

Cite

RIS / Bibtex

APA

Thomas, A., Kamble, S., Deshkar, S., Kothapalli, L., & Chitlange, S. (2021). Bioavailability of berberine: challenges and solutions. İstanbul Journal of Pharmacy, 51(1), 141-153. https://izlik.org/JA68HB64EF

AMA

1.Thomas A, Kamble S, Deshkar S, Kothapalli L, Chitlange S. Bioavailability of berberine: challenges and solutions. iujp. 2021;51(1):141-153. https://izlik.org/JA68HB64EF

Chicago

Thomas, Asha, Seema Kamble, Sanjeevani Deshkar, Lata Kothapalli, and Sohan Chitlange. 2021. “Bioavailability of Berberine: Challenges and Solutions”. İstanbul Journal of Pharmacy 51 (1): 141-53. https://izlik.org/JA68HB64EF.

EndNote

Thomas A, Kamble S, Deshkar S, Kothapalli L, Chitlange S (April 1, 2021) Bioavailability of berberine: challenges and solutions. İstanbul Journal of Pharmacy 51 1 141–153.

IEEE

[1]A. Thomas, S. Kamble, S. Deshkar, L. Kothapalli, and S. Chitlange, “Bioavailability of berberine: challenges and solutions”, iujp, vol. 51, no. 1, pp. 141–153, Apr. 2021, [Online]. Available: https://izlik.org/JA68HB64EF

ISNAD

Thomas, Asha - Kamble, Seema - Deshkar, Sanjeevani - Kothapalli, Lata - Chitlange, Sohan. “Bioavailability of Berberine: Challenges and Solutions”. İstanbul Journal of Pharmacy 51/1 (April 1, 2021): 141-153. https://izlik.org/JA68HB64EF.

JAMA

1.Thomas A, Kamble S, Deshkar S, Kothapalli L, Chitlange S. Bioavailability of berberine: challenges and solutions. iujp. 2021;51:141–153.

MLA

Thomas, Asha, et al. “Bioavailability of Berberine: Challenges and Solutions”. İstanbul Journal of Pharmacy, vol. 51, no. 1, Apr. 2021, pp. 141-53, https://izlik.org/JA68HB64EF.

Vancouver

1.Asha Thomas, Seema Kamble, Sanjeevani Deshkar, Lata Kothapalli, Sohan Chitlange. Bioavailability of berberine: challenges and solutions. iujp [Internet]. 2021 Apr. 1;51(1):141-53. Available from: https://izlik.org/JA68HB64EF