Cytotoxicity and DNA protective effects of the Terfezia and Picoa species from the eastern region of Turkey

Mehmet Akyüz; Işık Didem Karagöz; Şule İnci; İbrahim Halil Kılıç; Sevda Kırbağ; Başak Simitçioğlu

Cytotoxicity and DNA protective effects of the Terfezia and Picoa species from the eastern region of Turkey

Abstract

Background and Aims: This study aims to investigate the cytotoxicity and DNA protective effects of semi-arid, arid, or desert truffles such as the Terfezia and Picoa species. Methods: The DNA protective effects of the Terfezia and Picoa species was evaluated using plasmid pBR322 DNA treated with UV and H2O2. The cytotoxic effects of water and methanol extracts of the Terfezia and Picoa species on H1299 and HUVEC cells were evaluated using the MTT assay. Results: Higher concentrations of T. olbiensis and P. lefebvrei extracts have demonstrated a DNA protective effect. The water extract of P. juniperi only at a 40 mg/mL concentration demonstrated a DNA-protective effect, whereas T. boudieri extract did not show any DNA-protective effect at all concentrations tested. H1299 cells showed more sensitivity to the water extract of T. olbiensis (4.66%), P. juniperi (12.04%), P. lefebvrei (21.93%), and the methanol extract of T. boudieri (20.93%). In general, the water and methanol extracts of the Terfezia and Picoa species demonstrated the least cytotoxic effects on HUVEC cells, except for the water extract of P. juniperi (38.46%). Conclusions: In conclusion, results obtained from this study show that the Terfezia and Picoa truffle species have potential DNA protective and cancer prevention properties.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacology and Pharmaceutical Sciences, Health Care Administration

Journal Section

Research Article

Authors

Mehmet Akyüz ^* This is me
0000-0003-3986-3498
Türkiye

Işık Didem Karagöz This is me
0000-0001-6527-2750
Türkiye

Şule İnci This is me
0000-0002-4022-5269
Türkiye

İbrahim Halil Kılıç This is me
0000-0002-0272-5131
Türkiye

Sevda Kırbağ This is me
0000-0002-4337-8236
Türkiye

Başak Simitçioğlu This is me
0000-0002-2678-569X
Türkiye

Publication Date

August 31, 2021

Submission Date

September 16, 2020

Acceptance Date

January 18, 2021

Published in Issue

Year 2021 Volume: 51 Number: 2

IZ

https://izlik.org/JA62EP65MT

Cite

RIS / Bibtex

APA

Akyüz, M., Karagöz, I. D., İnci, Ş., Kılıç, İ. H., Kırbağ, S., & Simitçioğlu, B. (2021). Cytotoxicity and DNA protective effects of the Terfezia and Picoa species from the eastern region of Turkey. İstanbul Journal of Pharmacy, 51(2), 198-203. https://izlik.org/JA62EP65MT

AMA

1.Akyüz M, Karagöz ID, İnci Ş, Kılıç İH, Kırbağ S, Simitçioğlu B. Cytotoxicity and DNA protective effects of the Terfezia and Picoa species from the eastern region of Turkey. iujp. 2021;51(2):198-203. https://izlik.org/JA62EP65MT

Chicago

Akyüz, Mehmet, Işık Didem Karagöz, Şule İnci, İbrahim Halil Kılıç, Sevda Kırbağ, and Başak Simitçioğlu. 2021. “Cytotoxicity and DNA Protective Effects of the Terfezia and Picoa Species from the Eastern Region of Turkey”. İstanbul Journal of Pharmacy 51 (2): 198-203. https://izlik.org/JA62EP65MT.

EndNote

Akyüz M, Karagöz ID, İnci Ş, Kılıç İH, Kırbağ S, Simitçioğlu B (August 1, 2021) Cytotoxicity and DNA protective effects of the Terfezia and Picoa species from the eastern region of Turkey. İstanbul Journal of Pharmacy 51 2 198–203.

IEEE

[1]M. Akyüz, I. D. Karagöz, Ş. İnci, İ. H. Kılıç, S. Kırbağ, and B. Simitçioğlu, “Cytotoxicity and DNA protective effects of the Terfezia and Picoa species from the eastern region of Turkey”, iujp, vol. 51, no. 2, pp. 198–203, Aug. 2021, [Online]. Available: https://izlik.org/JA62EP65MT

ISNAD

Akyüz, Mehmet - Karagöz, Işık Didem - İnci, Şule - Kılıç, İbrahim Halil - Kırbağ, Sevda - Simitçioğlu, Başak. “Cytotoxicity and DNA Protective Effects of the Terfezia and Picoa Species from the Eastern Region of Turkey”. İstanbul Journal of Pharmacy 51/2 (August 1, 2021): 198-203. https://izlik.org/JA62EP65MT.

JAMA

1.Akyüz M, Karagöz ID, İnci Ş, Kılıç İH, Kırbağ S, Simitçioğlu B. Cytotoxicity and DNA protective effects of the Terfezia and Picoa species from the eastern region of Turkey. iujp. 2021;51:198–203.

MLA

Akyüz, Mehmet, et al. “Cytotoxicity and DNA Protective Effects of the Terfezia and Picoa Species from the Eastern Region of Turkey”. İstanbul Journal of Pharmacy, vol. 51, no. 2, Aug. 2021, pp. 198-03, https://izlik.org/JA62EP65MT.

Vancouver

1.Mehmet Akyüz, Işık Didem Karagöz, Şule İnci, İbrahim Halil Kılıç, Sevda Kırbağ, Başak Simitçioğlu. Cytotoxicity and DNA protective effects of the Terfezia and Picoa species from the eastern region of Turkey. iujp [Internet]. 2021 Aug. 1;51(2):198-203. Available from: https://izlik.org/JA62EP65MT