Anti-fertility and antisteroidogenic activity of Clerodendrum serratum in mature male rats

Navaneetha Krishnan Subramaniyan; Nagarajan Govinda Rajan; Karthikeyan Elumalai; Sathyanathan Viswanathan; Jayaraman Rajangam; Preeti Gutha; Sivaneswari Srinivasan

Anti-fertility and antisteroidogenic activity of Clerodendrum serratum in mature male rats

Abstract

Background and Aims: The study was designed to evaluate the anti-fertility effect of methanolic extract of Clerodendrum serratum (MECS) on mature male rats. Methods: The vehicles and MECS were administered orally to four groups of forty male albino rats on consecutive days for 30 days. At the end of the experimental period, five animals from both the control and experimental groups were given anesthesia and the animal reproductive organs were collected and anti-fertility effect evaluated by studying the following parameters (i) Body and reproductive organ weight (ii) Biochemical estimation (iii) Reproductive hormone analysis (iv) Abnormalities in reproductive organ histology. Another five rats in each group were subjected to fertility testing. Results: This study shows that female rats which mated with MECS treated male rats delivered fewer pups than those which mated with the control rats. An antisteroidogenic effect was revealed through the increased concentration of testicular cholesterol and ascorbic acid in MECS treated rats. However, testicular Δ 5-3β-hydroxysteroid dehydrogenase (Δ5-3β-HSD), glucose-6-phosphate dehydrogenase (G-6-PD); serum reproductive hormones testosterone, FSH and LH were significantly reduced. Conclusion: The present investigation discovered the antisteroidogenic effect of MECS, which confirms the male antifertility effect of this plant. This encourages the traditional use of this plant in the Indian subcontinent as a male contraceptive.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacology and Pharmaceutical Sciences, Health Care Administration

Journal Section

Research Article

Authors

Navaneetha Krishnan Subramaniyan ^* This is me
0000-0002-2450-3062
Palestine

Nagarajan Govinda Rajan This is me
India

Karthikeyan Elumalai This is me
0000-0002-6259-5332
India

Sathyanathan Viswanathan This is me
India

Jayaraman Rajangam This is me
0000-0002-6367-0365
India

Preeti Gutha This is me
0000-0002-4737-7898
India

Sivaneswari Srinivasan This is me
0000-0002-1630-9040
India

Publication Date

August 31, 2021

Submission Date

April 21, 2020

Acceptance Date

January 8, 2021

Published in Issue

Year 2021 Volume: 51 Number: 2

IZ

https://izlik.org/JA44HT35FP

Cite

RIS / Bibtex

APA

Subramaniyan, N. K., Rajan, N. G., Elumalai, K., Viswanathan, S., Rajangam, J., Gutha, P., & Srinivasan, S. (2021). Anti-fertility and antisteroidogenic activity of Clerodendrum serratum in mature male rats. İstanbul Journal of Pharmacy, 51(2), 212-220. https://izlik.org/JA44HT35FP

AMA

1.Subramaniyan NK, Rajan NG, Elumalai K, et al. Anti-fertility and antisteroidogenic activity of Clerodendrum serratum in mature male rats. iujp. 2021;51(2):212-220. https://izlik.org/JA44HT35FP

Chicago

Subramaniyan, Navaneetha Krishnan, Nagarajan Govinda Rajan, Karthikeyan Elumalai, et al. 2021. “Anti-Fertility and Antisteroidogenic Activity of Clerodendrum Serratum in Mature Male Rats”. İstanbul Journal of Pharmacy 51 (2): 212-20. https://izlik.org/JA44HT35FP.

EndNote

Subramaniyan NK, Rajan NG, Elumalai K, Viswanathan S, Rajangam J, Gutha P, Srinivasan S (August 1, 2021) Anti-fertility and antisteroidogenic activity of Clerodendrum serratum in mature male rats. İstanbul Journal of Pharmacy 51 2 212–220.

IEEE

[1]N. K. Subramaniyan et al., “Anti-fertility and antisteroidogenic activity of Clerodendrum serratum in mature male rats”, iujp, vol. 51, no. 2, pp. 212–220, Aug. 2021, [Online]. Available: https://izlik.org/JA44HT35FP

ISNAD

Subramaniyan, Navaneetha Krishnan - Rajan, Nagarajan Govinda - Elumalai, Karthikeyan - Viswanathan, Sathyanathan - Rajangam, Jayaraman - Gutha, Preeti - Srinivasan, Sivaneswari. “Anti-Fertility and Antisteroidogenic Activity of Clerodendrum Serratum in Mature Male Rats”. İstanbul Journal of Pharmacy 51/2 (August 1, 2021): 212-220. https://izlik.org/JA44HT35FP.

JAMA

1.Subramaniyan NK, Rajan NG, Elumalai K, Viswanathan S, Rajangam J, Gutha P, Srinivasan S. Anti-fertility and antisteroidogenic activity of Clerodendrum serratum in mature male rats. iujp. 2021;51:212–220.

MLA

Subramaniyan, Navaneetha Krishnan, et al. “Anti-Fertility and Antisteroidogenic Activity of Clerodendrum Serratum in Mature Male Rats”. İstanbul Journal of Pharmacy, vol. 51, no. 2, Aug. 2021, pp. 212-20, https://izlik.org/JA44HT35FP.

Vancouver

1.Navaneetha Krishnan Subramaniyan, Nagarajan Govinda Rajan, Karthikeyan Elumalai, Sathyanathan Viswanathan, Jayaraman Rajangam, Preeti Gutha, Sivaneswari Srinivasan. Anti-fertility and antisteroidogenic activity of Clerodendrum serratum in mature male rats. iujp [Internet]. 2021 Aug. 1;51(2):212-20. Available from: https://izlik.org/JA44HT35FP