Research Article
BibTex RIS Cite
Year 2017, Volume: 47 Issue: 3, 77 - 83, 11.10.2017
https://doi.org/10.5152/IstanbulJPharm.2017.0013

Abstract

References

  • Referans 1: Prof. Dr. Ayşe CAN aysecan@istanbul.edu.tr
  • Referans 2: Prof. Dr. Uzay Görmüş druzay@gmail.com

Evaluation of anticancer effects of Aloe vera and aloe emodin on B16F10 murine melanoma and NIH3T3 mouse embryogenic fibroblast cells

Year 2017, Volume: 47 Issue: 3, 77 - 83, 11.10.2017
https://doi.org/10.5152/IstanbulJPharm.2017.0013

Abstract

Aloe vera (L.) Burm. f.
is well known for its beneficial effects on the skin. Moreover, the
antioxidant, immunostimulant, and anticancer effects of the plant leaf extracts
have been reported in scientific research. This study was conducted to
demonstrate the cytotoxic effects of several leaf extracts and aloe emodin (AE)
on a type of skin cancer. A. vera aqueous and methanolic extracts of fresh
leaves, methanolic extract of dried leaves, and leaf gel extract (AVG) were
prepared separately. Cytotoxicity was assessed using the MTT test. Apoptosis
and necrosis were detected by flow cytometry using Annexin V/PI. All the
extracts exhibited a selective cytotoxic effect on the cells. The mechanism of
AVG cytotoxicity on B16F10 murine melanoma cells was found to be apoptosis, whereas
that of AE was necrosis. The observation that treatment with AVG delayed the
apoptosis in NIH3T3 cells, while it exerted an apoptotic activity on B16F10
cells, provides some scientific evidence for the folkloric and alternative uses
of A. vera gel as a protective and skin healer. Therefore, A. vera gel and aloe
emodin can be used as potential targets for anticancer drug research. 

References

  • Referans 1: Prof. Dr. Ayşe CAN aysecan@istanbul.edu.tr
  • Referans 2: Prof. Dr. Uzay Görmüş druzay@gmail.com
There are 2 citations in total.

Details

Primary Language English
Subjects Pharmacology and Pharmaceutical Sciences
Journal Section Original Article
Authors

Eda Çandöken

Serap Erdem Kuruca This is me

Nuriye Akev

Publication Date October 11, 2017
Submission Date July 14, 2017
Published in Issue Year 2017 Volume: 47 Issue: 3

Cite

APA Çandöken, E., Erdem Kuruca, S., & Akev, N. (2017). Evaluation of anticancer effects of Aloe vera and aloe emodin on B16F10 murine melanoma and NIH3T3 mouse embryogenic fibroblast cells. İstanbul Journal of Pharmacy, 47(3), 77-83. https://doi.org/10.5152/IstanbulJPharm.2017.0013
AMA Çandöken E, Erdem Kuruca S, Akev N. Evaluation of anticancer effects of Aloe vera and aloe emodin on B16F10 murine melanoma and NIH3T3 mouse embryogenic fibroblast cells. iujp. October 2017;47(3):77-83. doi:10.5152/IstanbulJPharm.2017.0013
Chicago Çandöken, Eda, Serap Erdem Kuruca, and Nuriye Akev. “Evaluation of Anticancer Effects of Aloe Vera and Aloe Emodin on B16F10 Murine Melanoma and NIH3T3 Mouse Embryogenic Fibroblast Cells”. İstanbul Journal of Pharmacy 47, no. 3 (October 2017): 77-83. https://doi.org/10.5152/IstanbulJPharm.2017.0013.
EndNote Çandöken E, Erdem Kuruca S, Akev N (October 1, 2017) Evaluation of anticancer effects of Aloe vera and aloe emodin on B16F10 murine melanoma and NIH3T3 mouse embryogenic fibroblast cells. İstanbul Journal of Pharmacy 47 3 77–83.
IEEE E. Çandöken, S. Erdem Kuruca, and N. Akev, “Evaluation of anticancer effects of Aloe vera and aloe emodin on B16F10 murine melanoma and NIH3T3 mouse embryogenic fibroblast cells”, iujp, vol. 47, no. 3, pp. 77–83, 2017, doi: 10.5152/IstanbulJPharm.2017.0013.
ISNAD Çandöken, Eda et al. “Evaluation of Anticancer Effects of Aloe Vera and Aloe Emodin on B16F10 Murine Melanoma and NIH3T3 Mouse Embryogenic Fibroblast Cells”. İstanbul Journal of Pharmacy 47/3 (October 2017), 77-83. https://doi.org/10.5152/IstanbulJPharm.2017.0013.
JAMA Çandöken E, Erdem Kuruca S, Akev N. Evaluation of anticancer effects of Aloe vera and aloe emodin on B16F10 murine melanoma and NIH3T3 mouse embryogenic fibroblast cells. iujp. 2017;47:77–83.
MLA Çandöken, Eda et al. “Evaluation of Anticancer Effects of Aloe Vera and Aloe Emodin on B16F10 Murine Melanoma and NIH3T3 Mouse Embryogenic Fibroblast Cells”. İstanbul Journal of Pharmacy, vol. 47, no. 3, 2017, pp. 77-83, doi:10.5152/IstanbulJPharm.2017.0013.
Vancouver Çandöken E, Erdem Kuruca S, Akev N. Evaluation of anticancer effects of Aloe vera and aloe emodin on B16F10 murine melanoma and NIH3T3 mouse embryogenic fibroblast cells. iujp. 2017;47(3):77-83.