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Antioxidant and Antimicrobial Activity of Ferulago trojana E. Akalın & Pimenov

Year 2017, Volume 47, Issue 3, 101 - 106, 11.10.2017
https://doi.org/10.5152/IstanbulJPharm.2017.0016

Abstract

Ferulago W. Koch is a genus in the Apiaceae family comprising 34 species, of which 18 are endemic in Turkey. Ferulago species have been known since the time of Dioscorides and have been used in folk medicine for their sedative, tonic, digestive, carminative, and aphrodisiac effects, as well as for the treatment of intestinal worms and hemorrhoids. This study was conducted to evaluate the polyphenolic contents and antioxidant activities of methanol extracts of the aerial parts (HFT) and rhizomes (RFT) of Ferulago trojana E. Akalın & Pimenov by measuring their ability to inhibit lipid peroxidation induced by Fe3+-ascorbate, their DPPH· and ABTS·+ scavenging activities, and their ferric reducing antioxidant power (FRAP value). The methanol extracts were also examined for their antimicrobial activity using the microbroth dilution technique. Results showed that the methanol extracts of the aerial parts of the plant, containing the highest amount of total phenolic content and flavonoids, exhibited antioxidative potential for the chain-breaking inhibition of lipid peroxidation and showed the strongest hydrogen and single electron donor activities, which could thus serve as a free radical scavenger, act as a reductant, and provide protection against oxidative stress. Although the methanol extract of rhizomes did not exhibit any inhibitory effect on lipid peroxidation, it is possible that it might also have protective effects against oxidative damage by scavenging free radicals and acting as a reductant. While both the methanol extracts of the aerial parts and rhizomes of F. trojana were effective against Staphylococcus aureus, Methicillin-resistant S. aureus (MRSA), and S. epidermidis,  the extracts showed no activity against Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. In addition, the methanol extract of rhizomes of F. trojana exhibited antibacterial activity against Proteus mirabilis and antifungal activity against the yeast Candida albicans. 

References

  • Akalın E, Pimenov MG (2004). Ferulago trojana (Umbelliferae), a new species from western Turkey. Bot J Linn Soc 146: 499-504.
  • Akalın E (1999). Taxonomical studies on the genus Ferulago in Western Anatolia. Unpublished PhD Thesis, Istanbul University, Istanbul.
  • Alkhatib R, Hennebelle T, Roumy V, Sahpaz S, Süzgeç S, Akalın E, Mericli AH, Bailleul F (2009). Coumarins, caffeoyl derivatives and a monoterpenoid glycoside from Ferulago asparigifolia. Biochem Syst Ecol 37: 230-233.
  • Azarbani F, Saki Z, Mohammadi A (2012). Phenolic contents, antibacterial and antioxidant activities of flower, leaf and stem extracts of Ferulago angulata (Schlecht) Boiss. Int J Pharm Pharm Sci 6: 123-125.
  • Başer KHC, Demirci B, Duman H (2001). Composition of the essential oil of Ferulago asparigifolia Boiss. from Turkey. J Essent Oil Res 13: 134-135.
  • Başer KHC, Demirci B, Özek T, Akalın E, Özhatay N (2002). Micro-distilled volatile compounds from Ferulago species growing in Western Turkey. Pharm Biology 40: 466-471.
  • Baytop T. Türkiye’de Bitkilerle Tedavi (1999). İstanbul Üniversitesi Eczacılık Fakültesi Yayınları, Nobel Tıp Basımevi, 2.baskı, İstanbul, pp. 348-349.
  • Benzie IFF, Strain JJ (1996). The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: The FRAP assay. Anal Biochem 239:70-76.
  • Brand-Williams W, Cuvelier ME, Berset C (1995). Use of a free radical method to evaluate antioxidant activity. Food Sci Technol 28: 25-30.
  • Buege JA, Aust SD (1978). Lipid peroxidation. Method Enzymol 52: 302-310.
  • Chalchat JC, Garry R, Gorunovic MS, Bogavac PM (1992). Composition of the essential oil of Ferulago sylvatica (Besser) Reichenb. Pharmazie 47: 10-11
  • Clinical and Laboratory Standards Institute (CLSI) (2015). Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically: Approved Standard M7-A10. Wayne, Pennsylvania.
  • Clinical and Laboratory Standards Institute (CLSI) (2008). Reference Method for Broth Dilution Antifungal Susceptbility Testing of Yeasts; Approved Standart Third Edition. Wayne M27-A3 Wayne, Pennsylvania.
  • Cushnie TPT, Lamb AJ (2005). Antimicrobial activity of flavonoids. Int J Antimicrob Agents 26: 343-356.
  • Çakar B (2010). Isolation of secondery metabolites of Ferulago idaea and Ferulago trojana plants, investigation of their antioxidant and anticholinesterase activities. Unpublished MSc Thesis, Istanbul Technical University, Istanbul.
  • Davis PH, Mill RR, Tan K (1988). Flora of Turkey and the East Aegean Islands, Vol. 10, pp. 145–154 (Suppl. 1). Edinburgh University Press, Edinburgh.
  • Dikpınar T (2017). The active constituents isolation from Ferulago trachycarpa Boiss. by antimicrobial activity-guided. Unpublished MSc Thesis, Marmara University, Istanbul.
  • Doğanca S, Ulubelen A, Tuzlacı E (1991). 1-Acetylhydroquinone 4-galactoside from Ferulago aucheri. Phytochem 30: 2803-2805.
  • Duh PD, Tu YY, Yen GC (1999). Antioxidant activity of water extract of Harng Jyur (Chrysanthemum morifolium Ramat). Lebensm Wiss Technol 32: 269-277.
  • Erdemoğlu N, Akalın E, Akgöç M, Çıkrıkçı S, Bilsel G (2008). Comparison of the seed oils of Ferulago trachycarpa Boiss. different localities with respect to fatty acids. Rec Nat Prod 2: 13-18.
  • Erdurak CS, Coşkun M, Demirci B, Başer KHC (2006). Composition of the essential oil of fruits and roots of Ferulago isaurica Peşmen and F. syriaca Boiss. (Umbelliferae) from Turkey. Flavour Fragr J 21: 118-121.
  • Jiménez B, Concepción Grande M, Anaya J, Torres P, Grande M (2000). Coumarins from Ferulago capillaris and F. brachyloba. Phytochem 53: 1025-1031.
  • Kӓhkönen MP, Hopia AN, Vuorela HJ, Rauha J-P, Pihlaja K, Kujala TS, Heinonen M (1999) Antioxidant activity of plant extracts containing phenolic compounds. J Agric Food Chem 47: 3954-3962.
  • Kandemir A & Hedge IC (2007). An anomalous Ferulago (Apiaceae) from eastern Turkey. Willdenowia 37: 273-276.
  • Kılıç CS, Okada Y, Coşkun M, Okuyama T (2006). New furanocoumarins isolated from the roots of Ferulago isaurica Peşmen growing in Turkey. Heterocycles 69: 481-486.
  • Kiziltas H, Eki, S, Bayramoglu M, Akbas E, Oto G, Yildirim S, Ozgokce F (2017). Antioxidant properties of Ferulago angulata and its hepatoprotective effect against N-nitrosodimethylamine-induced oxidative stress in rats. Pharm Biol 55: 888-897.
  • Mileski KS, Džamić AM, Ćirić AD, Ristić MS, Grujić SM, Matevski VS, Marin, PD (2015). Composition, antimicrobial and antioxidant properties of endemic species Ferulago macedonica Micevski & E. Mayer. Rec Nat Prod 9: 208-223.
  • Miski M, Moubasher HA & Mabry TJ (1990). Sesquiterpene aryl esters from Ferulago antiochia. Phytochem 29: 881-886.
  • Özhatay N, E Akalın (2000). A New species of Ferulago W.Koch (Umbelliferae) from North-west Turkey. Bot J Linn Soc 133: 353-342.
  • Peşmen H (1972). Ferulago W.Koch In: Davis PH (ed), Flora of Turkey and the East Aegean Islands, Vol.4: 453-471, Edinburgh University Press, Edinburgh.
  • Pietta P-G (2000). Flavonoids as antioxidants. J Nat Prod 63: 1035-1042.
  • Pimenov MG, Leonov MV (1993). The Genera of the Umbelliferae, A Nomenclator. London: Royal Botanic Gardens Kew.
  • Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C (1999). Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radical Bio Med 26: 1231-1237.
  • Rios JL & Recio MC (2005). Medicinal plants and antimicrobial activity. J Ethnopharmacol 100: 80-84.
  • Rustaiyan A, Yari M, Masoudi S, Aghjani Z (1999). Chemical constituents of the essential oil of Ferulago contracta Boiss & et Hausskn., a species endemic to Iran. J Essent Oil Res 11: 609-610.
  • Sakanaka S, Tachibana Y & Okada Y (2005). Preparation and antioxidant properties of extracts of Japanese persimmon leaf tea (kakinoha-cha). Food Chem 89: 569-575.
  • Slinkard K & Singleton VL (1977). Total phenol analysis: automation and comparison with manual methods. Am J Enol Viticult 28: 49-55.
  • Solanas JL, Crespo MB & Martin FG (2000). Una nueva especie Iberica de Ferulago Koch (Apiaceae). Anales del Jardín Botánico de Madrid 58: 101–107 (in Spanish with English abstract).
  • Yoti MJ & Assenov I (1995). Phyrochemical studies on Ferulago sylvatica. Fitoterapia 66: 88-89.
  • Wang M, Shao YLJ, Zhu N, Rangarajan M, LaVoie, EJ, Ho CT (1999). Antioxidative phenolic glycosides from Sage (Salvia officinalis). J Nat Prod 62: 454-456.

Year 2017, Volume 47, Issue 3, 101 - 106, 11.10.2017
https://doi.org/10.5152/IstanbulJPharm.2017.0016

Abstract

References

  • Akalın E, Pimenov MG (2004). Ferulago trojana (Umbelliferae), a new species from western Turkey. Bot J Linn Soc 146: 499-504.
  • Akalın E (1999). Taxonomical studies on the genus Ferulago in Western Anatolia. Unpublished PhD Thesis, Istanbul University, Istanbul.
  • Alkhatib R, Hennebelle T, Roumy V, Sahpaz S, Süzgeç S, Akalın E, Mericli AH, Bailleul F (2009). Coumarins, caffeoyl derivatives and a monoterpenoid glycoside from Ferulago asparigifolia. Biochem Syst Ecol 37: 230-233.
  • Azarbani F, Saki Z, Mohammadi A (2012). Phenolic contents, antibacterial and antioxidant activities of flower, leaf and stem extracts of Ferulago angulata (Schlecht) Boiss. Int J Pharm Pharm Sci 6: 123-125.
  • Başer KHC, Demirci B, Duman H (2001). Composition of the essential oil of Ferulago asparigifolia Boiss. from Turkey. J Essent Oil Res 13: 134-135.
  • Başer KHC, Demirci B, Özek T, Akalın E, Özhatay N (2002). Micro-distilled volatile compounds from Ferulago species growing in Western Turkey. Pharm Biology 40: 466-471.
  • Baytop T. Türkiye’de Bitkilerle Tedavi (1999). İstanbul Üniversitesi Eczacılık Fakültesi Yayınları, Nobel Tıp Basımevi, 2.baskı, İstanbul, pp. 348-349.
  • Benzie IFF, Strain JJ (1996). The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: The FRAP assay. Anal Biochem 239:70-76.
  • Brand-Williams W, Cuvelier ME, Berset C (1995). Use of a free radical method to evaluate antioxidant activity. Food Sci Technol 28: 25-30.
  • Buege JA, Aust SD (1978). Lipid peroxidation. Method Enzymol 52: 302-310.
  • Chalchat JC, Garry R, Gorunovic MS, Bogavac PM (1992). Composition of the essential oil of Ferulago sylvatica (Besser) Reichenb. Pharmazie 47: 10-11
  • Clinical and Laboratory Standards Institute (CLSI) (2015). Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically: Approved Standard M7-A10. Wayne, Pennsylvania.
  • Clinical and Laboratory Standards Institute (CLSI) (2008). Reference Method for Broth Dilution Antifungal Susceptbility Testing of Yeasts; Approved Standart Third Edition. Wayne M27-A3 Wayne, Pennsylvania.
  • Cushnie TPT, Lamb AJ (2005). Antimicrobial activity of flavonoids. Int J Antimicrob Agents 26: 343-356.
  • Çakar B (2010). Isolation of secondery metabolites of Ferulago idaea and Ferulago trojana plants, investigation of their antioxidant and anticholinesterase activities. Unpublished MSc Thesis, Istanbul Technical University, Istanbul.
  • Davis PH, Mill RR, Tan K (1988). Flora of Turkey and the East Aegean Islands, Vol. 10, pp. 145–154 (Suppl. 1). Edinburgh University Press, Edinburgh.
  • Dikpınar T (2017). The active constituents isolation from Ferulago trachycarpa Boiss. by antimicrobial activity-guided. Unpublished MSc Thesis, Marmara University, Istanbul.
  • Doğanca S, Ulubelen A, Tuzlacı E (1991). 1-Acetylhydroquinone 4-galactoside from Ferulago aucheri. Phytochem 30: 2803-2805.
  • Duh PD, Tu YY, Yen GC (1999). Antioxidant activity of water extract of Harng Jyur (Chrysanthemum morifolium Ramat). Lebensm Wiss Technol 32: 269-277.
  • Erdemoğlu N, Akalın E, Akgöç M, Çıkrıkçı S, Bilsel G (2008). Comparison of the seed oils of Ferulago trachycarpa Boiss. different localities with respect to fatty acids. Rec Nat Prod 2: 13-18.
  • Erdurak CS, Coşkun M, Demirci B, Başer KHC (2006). Composition of the essential oil of fruits and roots of Ferulago isaurica Peşmen and F. syriaca Boiss. (Umbelliferae) from Turkey. Flavour Fragr J 21: 118-121.
  • Jiménez B, Concepción Grande M, Anaya J, Torres P, Grande M (2000). Coumarins from Ferulago capillaris and F. brachyloba. Phytochem 53: 1025-1031.
  • Kӓhkönen MP, Hopia AN, Vuorela HJ, Rauha J-P, Pihlaja K, Kujala TS, Heinonen M (1999) Antioxidant activity of plant extracts containing phenolic compounds. J Agric Food Chem 47: 3954-3962.
  • Kandemir A & Hedge IC (2007). An anomalous Ferulago (Apiaceae) from eastern Turkey. Willdenowia 37: 273-276.
  • Kılıç CS, Okada Y, Coşkun M, Okuyama T (2006). New furanocoumarins isolated from the roots of Ferulago isaurica Peşmen growing in Turkey. Heterocycles 69: 481-486.
  • Kiziltas H, Eki, S, Bayramoglu M, Akbas E, Oto G, Yildirim S, Ozgokce F (2017). Antioxidant properties of Ferulago angulata and its hepatoprotective effect against N-nitrosodimethylamine-induced oxidative stress in rats. Pharm Biol 55: 888-897.
  • Mileski KS, Džamić AM, Ćirić AD, Ristić MS, Grujić SM, Matevski VS, Marin, PD (2015). Composition, antimicrobial and antioxidant properties of endemic species Ferulago macedonica Micevski & E. Mayer. Rec Nat Prod 9: 208-223.
  • Miski M, Moubasher HA & Mabry TJ (1990). Sesquiterpene aryl esters from Ferulago antiochia. Phytochem 29: 881-886.
  • Özhatay N, E Akalın (2000). A New species of Ferulago W.Koch (Umbelliferae) from North-west Turkey. Bot J Linn Soc 133: 353-342.
  • Peşmen H (1972). Ferulago W.Koch In: Davis PH (ed), Flora of Turkey and the East Aegean Islands, Vol.4: 453-471, Edinburgh University Press, Edinburgh.
  • Pietta P-G (2000). Flavonoids as antioxidants. J Nat Prod 63: 1035-1042.
  • Pimenov MG, Leonov MV (1993). The Genera of the Umbelliferae, A Nomenclator. London: Royal Botanic Gardens Kew.
  • Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C (1999). Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radical Bio Med 26: 1231-1237.
  • Rios JL & Recio MC (2005). Medicinal plants and antimicrobial activity. J Ethnopharmacol 100: 80-84.
  • Rustaiyan A, Yari M, Masoudi S, Aghjani Z (1999). Chemical constituents of the essential oil of Ferulago contracta Boiss & et Hausskn., a species endemic to Iran. J Essent Oil Res 11: 609-610.
  • Sakanaka S, Tachibana Y & Okada Y (2005). Preparation and antioxidant properties of extracts of Japanese persimmon leaf tea (kakinoha-cha). Food Chem 89: 569-575.
  • Slinkard K & Singleton VL (1977). Total phenol analysis: automation and comparison with manual methods. Am J Enol Viticult 28: 49-55.
  • Solanas JL, Crespo MB & Martin FG (2000). Una nueva especie Iberica de Ferulago Koch (Apiaceae). Anales del Jardín Botánico de Madrid 58: 101–107 (in Spanish with English abstract).
  • Yoti MJ & Assenov I (1995). Phyrochemical studies on Ferulago sylvatica. Fitoterapia 66: 88-89.
  • Wang M, Shao YLJ, Zhu N, Rangarajan M, LaVoie, EJ, Ho CT (1999). Antioxidative phenolic glycosides from Sage (Salvia officinalis). J Nat Prod 62: 454-456.

Details

Primary Language English
Subjects Pharmacology and Pharmacy
Journal Section Original Article
Authors

Sevda SÜZGEÇ SELÇUK>
MARMARA ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ, ECZACILIK MESLEK BİLİMLERİ BÖLÜMÜ, FARMAKOGNOZİ ANABİLİM DALI
Türkiye


Nurten ÖZSOY>
İSTANBUL ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ, TEMEL ECZACILIK BİLİMLERİ BÖLÜMÜ, BİYOKİMYA ANABİLİM DALI
Türkiye


Berna ÖZBEK ÇELİK This is me
İSTANBUL ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ, ECZACILIK TEKNOLOJİSİ BÖLÜMÜ, FARMASOTİK BİYOTEKNOLOJİ ANABİLİM DALI
Türkiye


Emine AKALIN URUŞAK>
İSTANBUL ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ, ECZACILIK TEKNOLOJİSİ BÖLÜMÜ, FARMASÖTİK BOTANİK ANABİLİM DALI
Türkiye

Publication Date October 11, 2017
Application Date October 20, 2017
Acceptance Date December 8, 2017
Published in Issue Year 2017, Volume 47, Issue 3

Cite

Bibtex @research article { iujp345407, journal = {İstanbul Journal of Pharmacy}, eissn = {2587-2087}, address = {İstanbul Üniversitesi Eczacılık Fakültesi Farmasötik Botanik AD}, publisher = {Istanbul University}, year = {2017}, volume = {47}, number = {3}, pages = {101 - 106}, doi = {10.5152/IstanbulJPharm.2017.0016}, title = {Antioxidant and Antimicrobial Activity of Ferulago trojana E. Akalın \& Pimenov}, key = {cite}, author = {Süzgeç Selçuk, Sevda and Özsoy, Nurten and Özbek Çelik, Berna and Akalın Uruşak, Emine} }
APA Süzgeç Selçuk, S. , Özsoy, N. , Özbek Çelik, B. & Akalın Uruşak, E. (2017). Antioxidant and Antimicrobial Activity of Ferulago trojana E. Akalın & Pimenov . İstanbul Journal of Pharmacy , 47 (3) , 101-106 . DOI: 10.5152/IstanbulJPharm.2017.0016
MLA Süzgeç Selçuk, S. , Özsoy, N. , Özbek Çelik, B. , Akalın Uruşak, E. "Antioxidant and Antimicrobial Activity of Ferulago trojana E. Akalın & Pimenov" . İstanbul Journal of Pharmacy 47 (2017 ): 101-106 <https://dergipark.org.tr/en/pub/iujp/issue/31365/345407>
Chicago Süzgeç Selçuk, S. , Özsoy, N. , Özbek Çelik, B. , Akalın Uruşak, E. "Antioxidant and Antimicrobial Activity of Ferulago trojana E. Akalın & Pimenov". İstanbul Journal of Pharmacy 47 (2017 ): 101-106
RIS TY - JOUR T1 - Antioxidant and Antimicrobial Activity of Ferulago trojana E. Akalın & Pimenov AU - SevdaSüzgeç Selçuk, NurtenÖzsoy, BernaÖzbek Çelik, EmineAkalın Uruşak Y1 - 2017 PY - 2017 N1 - doi: 10.5152/IstanbulJPharm.2017.0016 DO - 10.5152/IstanbulJPharm.2017.0016 T2 - İstanbul Journal of Pharmacy JF - Journal JO - JOR SP - 101 EP - 106 VL - 47 IS - 3 SN - -2587-2087 M3 - doi: 10.5152/IstanbulJPharm.2017.0016 UR - https://doi.org/10.5152/IstanbulJPharm.2017.0016 Y2 - 2017 ER -
EndNote %0 İstanbul Journal of Pharmacy Antioxidant and Antimicrobial Activity of Ferulago trojana E. Akalın & Pimenov %A Sevda Süzgeç Selçuk , Nurten Özsoy , Berna Özbek Çelik , Emine Akalın Uruşak %T Antioxidant and Antimicrobial Activity of Ferulago trojana E. Akalın & Pimenov %D 2017 %J İstanbul Journal of Pharmacy %P -2587-2087 %V 47 %N 3 %R doi: 10.5152/IstanbulJPharm.2017.0016 %U 10.5152/IstanbulJPharm.2017.0016
ISNAD Süzgeç Selçuk, Sevda , Özsoy, Nurten , Özbek Çelik, Berna , Akalın Uruşak, Emine . "Antioxidant and Antimicrobial Activity of Ferulago trojana E. Akalın & Pimenov". İstanbul Journal of Pharmacy 47 / 3 (October 2017): 101-106 . https://doi.org/10.5152/IstanbulJPharm.2017.0016
AMA Süzgeç Selçuk S. , Özsoy N. , Özbek Çelik B. , Akalın Uruşak E. Antioxidant and Antimicrobial Activity of Ferulago trojana E. Akalın & Pimenov. iujp. 2017; 47(3): 101-106.
Vancouver Süzgeç Selçuk S. , Özsoy N. , Özbek Çelik B. , Akalın Uruşak E. Antioxidant and Antimicrobial Activity of Ferulago trojana E. Akalın & Pimenov. İstanbul Journal of Pharmacy. 2017; 47(3): 101-106.
IEEE S. Süzgeç Selçuk , N. Özsoy , B. Özbek Çelik and E. Akalın Uruşak , "Antioxidant and Antimicrobial Activity of Ferulago trojana E. Akalın & Pimenov", İstanbul Journal of Pharmacy, vol. 47, no. 3, pp. 101-106, Oct. 2017, doi:10.5152/IstanbulJPharm.2017.0016