Antioxidant and Antimicrobial Activity of Ferulago trojana E. Akalın & Pimenov

Year 2017, Volume: 47 Issue: 3, 101 - 106, 11.10.2017

Sevda Süzgeç Selçuk , Nurten Özsoy , Berna Özbek Çelik Emine Akalın Uruşak

https://doi.org/10.5152/IstanbulJPharm.2017.0016

Abstract

Ferulago W. Koch is a
genus in the Apiaceae family comprising 34 species, of which 18 are endemic in
Turkey. Ferulago species have been known since the time of Dioscorides and have
been used in folk medicine for their sedative, tonic, digestive, carminative,
and aphrodisiac effects, as well as for the treatment of intestinal worms and
hemorrhoids. This study was conducted to evaluate the polyphenolic contents and
antioxidant activities of methanol extracts of the aerial parts (HFT) and
rhizomes (RFT) of Ferulago trojana E. Akalın & Pimenov by measuring their
ability to inhibit lipid peroxidation induced by Fe3+-ascorbate, their DPPH· and
ABTS·+ scavenging activities, and their ferric reducing antioxidant power (FRAP
value). The methanol extracts were also examined for their antimicrobial
activity using the microbroth dilution technique. Results showed that the
methanol extracts of the aerial parts of the plant, containing the highest
amount of total phenolic content and flavonoids, exhibited antioxidative
potential for the chain-breaking inhibition of lipid peroxidation and showed
the strongest hydrogen and single electron donor activities, which could thus
serve as a free radical scavenger, act as a reductant, and provide protection
against oxidative stress. Although the methanol extract of rhizomes did not
exhibit any inhibitory effect on lipid peroxidation, it is possible that it
might also have protective effects against oxidative damage by scavenging free
radicals and acting as a reductant. While both the methanol extracts of the
aerial parts and rhizomes of F. trojana were effective against Staphylococcus
aureus, Methicillin-resistant S. aureus (MRSA), and S. epidermidis,  the extracts showed no activity against
Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. In
addition, the methanol extract of rhizomes of F. trojana exhibited
antibacterial activity against Proteus mirabilis and antifungal activity
against the yeast Candida albicans. 

Keywords

Ferulago, F.trojana, antioxidant activity, antimicrobial activity

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