Antimicrobial peptides: Coming to the end of antibiotic era, the most promising agents

Year 2017, Volume: 47 Issue: 2, 72 - 76, 18.10.2017

Sibel Döşler

Abstract

Recently, because of the rising in multidrug
resistance from infectious agents, there is a prompted interest for the
development of new antimicrobial agents and new therapeutic strategies to
combat the infections caused by the resistant bacteria. Among them, the natural
bactericidal compounds, such as antimicrobial cationic peptides (AMPs) seems
very promising agents. AMPs are the important component of the innate immune
response to the surrounding microorganisms. This substances which can be
isolated from most of the living organisms, have various activity like broad
spectrum antibacterial, antifungal, antiviral, and antiprotozoal. However there
are some resistance mechanisms that affects the AMPs, because of the rapid
action and existing more than one mechanism of action, development of
resistance to AMPs is quite rare. Due to their many advantages and
characteristics, AMPs looks like a good candidate for being a new generation,
active antimicrobial agent for antimicrobial chemotherapy against especially
multi drug resistant bacteria and biofilms, either alone or in combination. 

Keywords

Antimicrobial peptides, antibiotic, resistance

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