Research Article
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Year 2018, Volume 48, Issue 3, 76 - 81, 01.12.2018

Abstract

References

  • Yang ZB, Hu DY, Zeng S, Song BA (2016) Novel hydrazone derivatives containing pyridine amide moiety: design, synthesis, and insecticidal activity. Bioorg Med Chem Lett 26: 1161-1164.

Synthesis, characterization and biological activity studies on amide derivatives

Year 2018, Volume 48, Issue 3, 76 - 81, 01.12.2018

Abstract

DOI : 10.26650/IstanbulJPharm.2018.18007


In this study, with intent to find out novel anti-biofilm and antiviral agents, a series of amide derivatives were synthesized and their structures were elucidated by FT-IR and 1H-NMR and 13C-NMR and MS methods. And also, their purity were proven by TLC, HPLC and elemental analyses. And finally, the synthesized compounds were examined for their biofilm formation and swarming motility inhibitory activities in P. aeruginosa PA01. These compounds were found to reduce biofilm formation by 8.7-25.6% and swarming motility by 18.3-33.8% in P. aeruginosa PA01 at a concentration of 200 μM. Besides, all of the compounds were evaluated for their antiviral activity against influenza A viruses. The plaque inhibition assays indicated that compound 6 (N-(4-{[5-(ethylamino)-1,3,4-thiadiazol-2-yl]methyl}phenyl)-4- fluorobenzamide) has considerable inhibitory effect on influenza A virus plaque formation.

References

  • Yang ZB, Hu DY, Zeng S, Song BA (2016) Novel hydrazone derivatives containing pyridine amide moiety: design, synthesis, and insecticidal activity. Bioorg Med Chem Lett 26: 1161-1164.

Details

Primary Language English
Subjects Pharmacology and Pharmacy
Journal Section Original Article
Authors

Sevda TÜRK This is me (Primary Author)
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Marmara University, 34668, İstanbul, Turkey


Kadir TURAN This is me
Department of Basic Pharmaceutical Sciences, Faculty of Pharmacy, Marmara University, 34668, İstanbul, Turkey


Seyhan ULUSOY This is me
Department of Biology, Faculty of Arts and Sciences, Süleyman Demirel University, 32260, Isparta,Turkey


Sevgi KARAKUŞ>
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Marmara University, 34668, İstanbul, Turkey


Gülgün BOŞGELMEZ-TINAZ This is me
Department of Basic Pharmaceutical Sciences, Faculty of Pharmacy, Marmara University, 34668, İstanbul, Turkey

Publication Date December 1, 2018
Submission Date September 12, 2018
Acceptance Date
Published in Issue Year 2018, Volume 48, Issue 3

Cite

Bibtex @research article { iujp475194, journal = {İstanbul Journal of Pharmacy}, eissn = {2587-2087}, address = {İstanbul Üniversitesi Eczacılık Fakültesi Farmasötik Botanik AD}, publisher = {Istanbul University}, year = {2018}, volume = {48}, number = {3}, pages = {76 - 81}, title = {Synthesis, characterization and biological activity studies on amide derivatives}, key = {cite}, author = {Türk, Sevda and Turan, Kadir and Ulusoy, Seyhan and Karakuş, Sevgi and Boşgelmez-tınaz, Gülgün} }
APA Türk, S. , Turan, K. , Ulusoy, S. , Karakuş, S. & Boşgelmez-tınaz, G. (2018). Synthesis, characterization and biological activity studies on amide derivatives . İstanbul Journal of Pharmacy , 48 (3) , 76-81 . Retrieved from https://dergipark.org.tr/en/pub/iujp/issue/42527/475194
MLA Türk, S. , Turan, K. , Ulusoy, S. , Karakuş, S. , Boşgelmez-tınaz, G. "Synthesis, characterization and biological activity studies on amide derivatives" . İstanbul Journal of Pharmacy 48 (2018 ): 76-81 <https://dergipark.org.tr/en/pub/iujp/issue/42527/475194>
Chicago Türk, S. , Turan, K. , Ulusoy, S. , Karakuş, S. , Boşgelmez-tınaz, G. "Synthesis, characterization and biological activity studies on amide derivatives". İstanbul Journal of Pharmacy 48 (2018 ): 76-81
RIS TY - JOUR T1 - Synthesis, characterization and biological activity studies on amide derivatives AU - SevdaTürk, KadirTuran, SeyhanUlusoy, SevgiKarakuş, GülgünBoşgelmez-tınaz Y1 - 2018 PY - 2018 N1 - DO - T2 - İstanbul Journal of Pharmacy JF - Journal JO - JOR SP - 76 EP - 81 VL - 48 IS - 3 SN - -2587-2087 M3 - UR - Y2 - 2023 ER -
EndNote %0 İstanbul Journal of Pharmacy Synthesis, characterization and biological activity studies on amide derivatives %A Sevda Türk , Kadir Turan , Seyhan Ulusoy , Sevgi Karakuş , Gülgün Boşgelmez-tınaz %T Synthesis, characterization and biological activity studies on amide derivatives %D 2018 %J İstanbul Journal of Pharmacy %P -2587-2087 %V 48 %N 3 %R %U
ISNAD Türk, Sevda , Turan, Kadir , Ulusoy, Seyhan , Karakuş, Sevgi , Boşgelmez-tınaz, Gülgün . "Synthesis, characterization and biological activity studies on amide derivatives". İstanbul Journal of Pharmacy 48 / 3 (December 2018): 76-81 .
AMA Türk S. , Turan K. , Ulusoy S. , Karakuş S. , Boşgelmez-tınaz G. Synthesis, characterization and biological activity studies on amide derivatives. iujp. 2018; 48(3): 76-81.
Vancouver Türk S. , Turan K. , Ulusoy S. , Karakuş S. , Boşgelmez-tınaz G. Synthesis, characterization and biological activity studies on amide derivatives. İstanbul Journal of Pharmacy. 2018; 48(3): 76-81.
IEEE S. Türk , K. Turan , S. Ulusoy , S. Karakuş and G. Boşgelmez-tınaz , "Synthesis, characterization and biological activity studies on amide derivatives", İstanbul Journal of Pharmacy, vol. 48, no. 3, pp. 76-81, Dec. 2018