This study was designed to evaluate and
correlate the biological, phytochemical, and physicochemical properties of two
NSS (Nigella sativa seed) oils (N1 and N2). The biological activity was evaluated
in terms of antibacterial, antioxidant (nitric oxide scavenging), antielastase,
antityrosinase, antimelanogenic, and anticancer activity. Physicochemical
properties including colour, total soluble solids (TSS), and density were also
investigated. N2 exhibited higher antibacterial, NO scavenging, extracellular
antimelanogenic, and anticancer activity against the HeLa cell line compared to
N1, which showed higher antityrosinase activity. TPC (total phenolic content)
and TFC (total flavonoid content) of N1 were significantly higher than N2 while
TTC (total tannin content) was higher in N2. In fact, TTC was strongly
correlated (R=1.000) with the antioxidant, extracellular antimelanogenic, and
HeLa cell inhibitory activity. To conclude, NSS oil may be considered as a
complementary and alternative therapy in the management of infectious and
chronic diseases but warrants further in vivo pharmacological validation and
toxicological analysis.
Primary Language | English |
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Subjects | Health Care Administration |
Journal Section | Original Article |
Authors | |
Publication Date | December 1, 2018 |
Submission Date | September 13, 2018 |
Published in Issue | Year 2018 Volume: 48 Issue: 3 |