Research Article
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Year 2018, Volume 48, Issue 3, 89 - 99, 01.12.2018

Abstract

References

  • Ahmad A, Husain A, Mujeeb M, Khan SA, Najmi AK, Siddique NA, Damanhouri ZA, Anwar F. (2013). A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pac J Trop Biomed 3(5): 337-352. Ahmad I, Tripathi J, Manik S, Umar L, JR. (2013). Preliminary Phytochemical Studies of the Miracle Herb of the Century, Nigella sativa L. (Black Seed). Indo Am J Pharm Res 3(4): 3000-3007. Ahmad S, Beg ZH. (2014). Mitigating role of thymoquinone rich fractions from Nigella sativa oil and its constituents, thymoquinone and limonene on lipidemic-oxidative injury in rats. Springerplus 3(1): 316. Alobaedi OH, Talib WH, Basheti IA. (2017). Antitumor effect of thymoquinone combined with resveratrol on mice transplanted with breast cancer. Asian Pac J Trop Biomed 10(4): 400-408. Andzouana M, Mombouli JB. (2011). Chemical composition and phytochemical screening of the leaves of Hymenocardiaulmoides and Vitexferruginea. Pak J Nutr 10(12): 1183-1189. Arici M, Sagdic O, Gecgel U. (2005). Antibacterial effect of Turkish black cumin (Nigella sativa L.) oils. Grasas y Aceites 56(4): 259-262. Aumeeruddy MZ, Zengin G, Mahomoodally MF. (2017). A review of the traditional and modern uses of Salvadora persica L.(Miswak): Toothbrush tree of Prophet Muhammad. J Ethnopharmacol 213: 409-444. Baharetha HM, Nassar ZD, Aisha AF, Ahamed MBK, Al-Suede FSR, Kadir MOA, Ismail Z, Majid AMSA. (2013). Proapoptotic and antimetastatic properties of supercritical CO2 extract of Nigella sativa Linn. against breast cancer cells. J Med Food 16(12): 1121-1130. Bieth J, Spiess B, Wermuth CG. (1974). The synthesis and analytical use of a highly sensitive and convenient substrate of elastase. Biochem Med 11(4): 350-357. Boussaid A, Chouaibi M, Rezig L, Hellal R, Donsì F, Ferrari G, Hamdi S. (2014). Physicochemical and bioactive properties of six honey samples from various floral origins from Tunisia. Arab J Chem 11: 265-274. Burits M, Bucar F. (2000). Antioxidant activity of Nigella sativa essential oil. Phytother Res 14(5): 323-328. Cakir M, Sakalar C, Sezen S, Aksu H, Kurt B, Canatan H. (2016). Thymoquinone confers higher cytotoxicity against triple negative breast cancer compared to estrogen receptor positive breast cancer through modulation of TNF receptor superfamily genes and P65 activity. Eur J Cancer 61: S138-S139. Cheikh-Rouhou S, Besbes S, Hentati B, Blecker C, Deroanne C, Attia H. (2007). Nigella sativa L.: Chemical composition and physicochemical characteristics of lipid fraction. Food Chem 101(2): 673-681. CLSI (2015). Performance standards for antimicrobial susceptibility testing; Twenty-second informational supplement. CLSI document M100-S22. Wayne, PA: Clinical and Laboratory Standards Institute. Eid AM, Elmarzugi NA, Abu Ayyash LM, Sawafta MN, Daana HI. (2017). A Review on the Cosmeceutical and External Applications of Nigella sativa. J Trop Med doi.org/10.1155/2017/7092514. Elkady AI. (2012). Crude extract of Nigella sativa inhibits proliferation and induces apoptosis in human cervical carcinoma HeLa cells. African Journal of Biotechnology, 11(64): 12710-12720. Farah IO. (2005). Assessment of cellular responses to oxidative stress using MCF-7 breast cancer cells, black seed (N. Sativa L.) extracts and H2O2. Int J Environ Res Public Health 2(3): 411-419. Feroz S, Uddin G. (2016). Phytochemical Analysis, Antimicrobial and Antioxidant Study of Nigella sativa Int J Pharm Chem 2(2): 36-43. Gilani AUH, Jabeen Q, Khan MAU. (2004). A review of medicinal uses and pharmacological activities of Nigella sativa. Pak J Biol Sci 7(4): 441-445. Goga A, Hasic S, Becirovic S, Cavar S. (2012). Phenolic compounds and antioxidant Activity of extracts of Nigella sativa L. Bull Chemists Technol Bosnia Herzegovina 39: 15-19.

Biological, phytochemical, and physico-chemical properties of two commercial Nigella sativa seed oils: A comparative analysis

Year 2018, Volume 48, Issue 3, 89 - 99, 01.12.2018

Abstract

This study was designed to evaluate and correlate the biological, phytochemical, and physicochemical properties of two NSS (Nigella sativa seed) oils (N1 and N2). The biological activity was evaluated in terms of antibacterial, antioxidant (nitric oxide scavenging), antielastase, antityrosinase, antimelanogenic, and anticancer activity. Physicochemical properties including colour, total soluble solids (TSS), and density were also investigated. N2 exhibited higher antibacterial, NO scavenging, extracellular antimelanogenic, and anticancer activity against the HeLa cell line compared to N1, which showed higher antityrosinase activity. TPC (total phenolic content) and TFC (total flavonoid content) of N1 were significantly higher than N2 while TTC (total tannin content) was higher in N2. In fact, TTC was strongly correlated (R=1.000) with the antioxidant, extracellular antimelanogenic, and HeLa cell inhibitory activity. To conclude, NSS oil may be considered as a complementary and alternative therapy in the management of infectious and chronic diseases but warrants further in vivo pharmacological validation and toxicological analysis.

References

  • Ahmad A, Husain A, Mujeeb M, Khan SA, Najmi AK, Siddique NA, Damanhouri ZA, Anwar F. (2013). A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pac J Trop Biomed 3(5): 337-352. Ahmad I, Tripathi J, Manik S, Umar L, JR. (2013). Preliminary Phytochemical Studies of the Miracle Herb of the Century, Nigella sativa L. (Black Seed). Indo Am J Pharm Res 3(4): 3000-3007. Ahmad S, Beg ZH. (2014). Mitigating role of thymoquinone rich fractions from Nigella sativa oil and its constituents, thymoquinone and limonene on lipidemic-oxidative injury in rats. Springerplus 3(1): 316. Alobaedi OH, Talib WH, Basheti IA. (2017). Antitumor effect of thymoquinone combined with resveratrol on mice transplanted with breast cancer. Asian Pac J Trop Biomed 10(4): 400-408. Andzouana M, Mombouli JB. (2011). Chemical composition and phytochemical screening of the leaves of Hymenocardiaulmoides and Vitexferruginea. Pak J Nutr 10(12): 1183-1189. Arici M, Sagdic O, Gecgel U. (2005). Antibacterial effect of Turkish black cumin (Nigella sativa L.) oils. Grasas y Aceites 56(4): 259-262. Aumeeruddy MZ, Zengin G, Mahomoodally MF. (2017). A review of the traditional and modern uses of Salvadora persica L.(Miswak): Toothbrush tree of Prophet Muhammad. J Ethnopharmacol 213: 409-444. Baharetha HM, Nassar ZD, Aisha AF, Ahamed MBK, Al-Suede FSR, Kadir MOA, Ismail Z, Majid AMSA. (2013). Proapoptotic and antimetastatic properties of supercritical CO2 extract of Nigella sativa Linn. against breast cancer cells. J Med Food 16(12): 1121-1130. Bieth J, Spiess B, Wermuth CG. (1974). The synthesis and analytical use of a highly sensitive and convenient substrate of elastase. Biochem Med 11(4): 350-357. Boussaid A, Chouaibi M, Rezig L, Hellal R, Donsì F, Ferrari G, Hamdi S. (2014). Physicochemical and bioactive properties of six honey samples from various floral origins from Tunisia. Arab J Chem 11: 265-274. Burits M, Bucar F. (2000). Antioxidant activity of Nigella sativa essential oil. Phytother Res 14(5): 323-328. Cakir M, Sakalar C, Sezen S, Aksu H, Kurt B, Canatan H. (2016). Thymoquinone confers higher cytotoxicity against triple negative breast cancer compared to estrogen receptor positive breast cancer through modulation of TNF receptor superfamily genes and P65 activity. Eur J Cancer 61: S138-S139. Cheikh-Rouhou S, Besbes S, Hentati B, Blecker C, Deroanne C, Attia H. (2007). Nigella sativa L.: Chemical composition and physicochemical characteristics of lipid fraction. Food Chem 101(2): 673-681. CLSI (2015). Performance standards for antimicrobial susceptibility testing; Twenty-second informational supplement. CLSI document M100-S22. Wayne, PA: Clinical and Laboratory Standards Institute. Eid AM, Elmarzugi NA, Abu Ayyash LM, Sawafta MN, Daana HI. (2017). A Review on the Cosmeceutical and External Applications of Nigella sativa. J Trop Med doi.org/10.1155/2017/7092514. Elkady AI. (2012). Crude extract of Nigella sativa inhibits proliferation and induces apoptosis in human cervical carcinoma HeLa cells. African Journal of Biotechnology, 11(64): 12710-12720. Farah IO. (2005). Assessment of cellular responses to oxidative stress using MCF-7 breast cancer cells, black seed (N. Sativa L.) extracts and H2O2. Int J Environ Res Public Health 2(3): 411-419. Feroz S, Uddin G. (2016). Phytochemical Analysis, Antimicrobial and Antioxidant Study of Nigella sativa Int J Pharm Chem 2(2): 36-43. Gilani AUH, Jabeen Q, Khan MAU. (2004). A review of medicinal uses and pharmacological activities of Nigella sativa. Pak J Biol Sci 7(4): 441-445. Goga A, Hasic S, Becirovic S, Cavar S. (2012). Phenolic compounds and antioxidant Activity of extracts of Nigella sativa L. Bull Chemists Technol Bosnia Herzegovina 39: 15-19.

Details

Primary Language English
Subjects Health Care Sciences and Services
Journal Section Original Article
Authors

Muhammad Zakariyyah AUMEERUDDY This is me
Department of Health Sciences, Faculty of Science, University of Mauritius, 230 Réduit, Mauritius


Zaahira AUMEERUDDY-ELALFİ This is me
Department of Health Sciences, Faculty of Science, University of Mauritius, 230 Réduit, Mauritius


Hudaa NEETOO This is me
Department of Agricultural and Food Science, Faculty of Agriculture, University of Mauritius, 230 Réduit, Mauritius


Gökhan ZENGİN This is me (Primary Author)
Department of Biology, Science Faculty, Selçuk University, 42250 Konya, Turkey


Bianca FİBRİCH This is me
Department of Plant and Soil Sciences, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria, South Africa


Sunelle RADEMAN This is me
Department of Plant and Soil Sciences, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria, South Africa


Analike Blom Van STADEN This is me
Department of Plant and Soil Sciences, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria, South Africa


Karina SZUMAN This is me
Department of Plant and Soil Sciences, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria, South Africa


İsa Anina LAMBRECHTS This is me
Department of Plant and Soil Sciences, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria, South Africa


Namrita LALL This is me
Department of Plant and Soil Sciences, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria, South Africa


Mohamad Fawzi MAHOMOODALLY This is me (Primary Author)
Department of Health Sciences, Faculty of Science, University of Mauritius, 230 Réduit, Mauritius

Publication Date December 1, 2018
Submission Date September 13, 2018
Acceptance Date
Published in Issue Year 2018, Volume 48, Issue 3

Cite

Bibtex @research article { iujp512483, journal = {İstanbul Journal of Pharmacy}, eissn = {2587-2087}, address = {İstanbul Üniversitesi Eczacılık Fakültesi Farmasötik Botanik AD}, publisher = {Istanbul University}, year = {2018}, volume = {48}, number = {3}, pages = {89 - 99}, title = {Biological, phytochemical, and physico-chemical properties of two commercial Nigella sativa seed oils: A comparative analysis}, key = {cite}, author = {Aumeeruddy, Muhammad Zakariyyah and Aumeeruddy-elalfi, Zaahira and Neetoo, Hudaa and Zengin, Gökhan and Fibrich, Bianca and Rademan, Sunelle and Staden, Analike Blom Van and Szuman, Karina and Lambrechts, İsa Anina and Lall, Namrita and Mahomoodally, Mohamad Fawzi} }
APA Aumeeruddy, M. Z. , Aumeeruddy-elalfi, Z. , Neetoo, H. , Zengin, G. , Fibrich, B. , Rademan, S. , Staden, A. B. V. , Szuman, K. , Lambrechts, İ. A. , Lall, N. & Mahomoodally, M. F. (2018). Biological, phytochemical, and physico-chemical properties of two commercial Nigella sativa seed oils: A comparative analysis . İstanbul Journal of Pharmacy , 48 (3) , 89-99 . Retrieved from https://dergipark.org.tr/en/pub/iujp/issue/42527/512483
MLA Aumeeruddy, M. Z. , Aumeeruddy-elalfi, Z. , Neetoo, H. , Zengin, G. , Fibrich, B. , Rademan, S. , Staden, A. B. V. , Szuman, K. , Lambrechts, İ. A. , Lall, N. , Mahomoodally, M. F. "Biological, phytochemical, and physico-chemical properties of two commercial Nigella sativa seed oils: A comparative analysis" . İstanbul Journal of Pharmacy 48 (2018 ): 89-99 <https://dergipark.org.tr/en/pub/iujp/issue/42527/512483>
Chicago Aumeeruddy, M. Z. , Aumeeruddy-elalfi, Z. , Neetoo, H. , Zengin, G. , Fibrich, B. , Rademan, S. , Staden, A. B. V. , Szuman, K. , Lambrechts, İ. A. , Lall, N. , Mahomoodally, M. F. "Biological, phytochemical, and physico-chemical properties of two commercial Nigella sativa seed oils: A comparative analysis". İstanbul Journal of Pharmacy 48 (2018 ): 89-99
RIS TY - JOUR T1 - Biological, phytochemical, and physico-chemical properties of two commercial Nigella sativa seed oils: A comparative analysis AU - Muhammad ZakariyyahAumeeruddy, ZaahiraAumeeruddy-elalfi, HudaaNeetoo, GökhanZengin, BiancaFibrich, SunelleRademan, Analike Blom VanStaden, KarinaSzuman, İsa AninaLambrechts, NamritaLall, Mohamad FawziMahomoodally Y1 - 2018 PY - 2018 N1 - DO - T2 - İstanbul Journal of Pharmacy JF - Journal JO - JOR SP - 89 EP - 99 VL - 48 IS - 3 SN - -2587-2087 M3 - UR - Y2 - 2023 ER -
EndNote %0 İstanbul Journal of Pharmacy Biological, phytochemical, and physico-chemical properties of two commercial Nigella sativa seed oils: A comparative analysis %A Muhammad Zakariyyah Aumeeruddy , Zaahira Aumeeruddy-elalfi , Hudaa Neetoo , Gökhan Zengin , Bianca Fibrich , Sunelle Rademan , Analike Blom Van Staden , Karina Szuman , İsa Anina Lambrechts , Namrita Lall , Mohamad Fawzi Mahomoodally %T Biological, phytochemical, and physico-chemical properties of two commercial Nigella sativa seed oils: A comparative analysis %D 2018 %J İstanbul Journal of Pharmacy %P -2587-2087 %V 48 %N 3 %R %U
ISNAD Aumeeruddy, Muhammad Zakariyyah , Aumeeruddy-elalfi, Zaahira , Neetoo, Hudaa , Zengin, Gökhan , Fibrich, Bianca , Rademan, Sunelle , Staden, Analike Blom Van , Szuman, Karina , Lambrechts, İsa Anina , Lall, Namrita , Mahomoodally, Mohamad Fawzi . "Biological, phytochemical, and physico-chemical properties of two commercial Nigella sativa seed oils: A comparative analysis". İstanbul Journal of Pharmacy 48 / 3 (December 2018): 89-99 .
AMA Aumeeruddy M. Z. , Aumeeruddy-elalfi Z. , Neetoo H. , Zengin G. , Fibrich B. , Rademan S. , Staden A. B. V. , Szuman K. , Lambrechts İ. A. , Lall N. , Mahomoodally M. F. Biological, phytochemical, and physico-chemical properties of two commercial Nigella sativa seed oils: A comparative analysis. iujp. 2018; 48(3): 89-99.
Vancouver Aumeeruddy M. Z. , Aumeeruddy-elalfi Z. , Neetoo H. , Zengin G. , Fibrich B. , Rademan S. , Staden A. B. V. , Szuman K. , Lambrechts İ. A. , Lall N. , Mahomoodally M. F. Biological, phytochemical, and physico-chemical properties of two commercial Nigella sativa seed oils: A comparative analysis. İstanbul Journal of Pharmacy. 2018; 48(3): 89-99.
IEEE M. Z. Aumeeruddy , Z. Aumeeruddy-elalfi , H. Neetoo , G. Zengin , B. Fibrich , S. Rademan , A. B. V. Staden , K. Szuman , İ. A. Lambrechts , N. Lall and M. F. Mahomoodally , "Biological, phytochemical, and physico-chemical properties of two commercial Nigella sativa seed oils: A comparative analysis", İstanbul Journal of Pharmacy, vol. 48, no. 3, pp. 89-99, Dec. 2018